2. Gene
  3. SH3BP1 - SH3 domain binding protein 1 Gene

SH3BP1 - SH3 domain binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ARHGAP43

Gene ID: 23616 | Gene type: protein coding

About SH3BP1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,639,669-37,656,117 (from NCBI)

This gene has 10 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in spleen (RPKM 13.4), appendix (RPKM 12.6) and 23 other tissues.

Summary

This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the Cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver Cancer cells and tissues. [provided by RefSeq, Mar 2017]

SH3BP1 Products(2)

mRNA Protein Name
NM_001350055.2 NP_001336984.1 SH3 domain-binding protein 1 isoform 2
NM_018957.6 NP_061830.3 SH3 domain-binding protein 1 isoform 1

SH3BP1 Protein Structure

BAR

BAR: BAR domain (2 - 252)

RhoGAP

RhoGAP: RhoGAP domain (292 - 438)

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  • 200
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  • 600
  • 701 a.a.
Protein Preferred Names Protein Names

SH3 domain-binding protein 1

3BP-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12830 SH3BP1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SH3BP1 VGNC VGNC:34565
Mus musculus SH3BP1 MGD MGI:104603
Rattus norvegicus SH3BP1 RGD RGD:1306275
Canis familiaris SH3BP1 VGNC VGNC:46117