SH3BP1 - SH3 domain binding protein 1 Gene

Also Known as ARHGAP43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23616

About SH3BP1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,639,669-37,656,117 (from NCBI)

This gene has 10 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in spleen (RPKM 13.4), appendix (RPKM 12.6) and 23 other tissues.

Summary

This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the Cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver Cancer cells and tissues. [provided by RefSeq, Mar 2017]

SH3BP1 Products (2)

mRNA	Protein	Name
NM_001350055.2	NP_001336984.1	SH3 domain-binding protein 1 isoform 2
NM_018957.6	NP_061830.3	SH3 domain-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	22891260	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	24841563	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in cell junction assembly	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	21658605	GOA
involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in negative regulation of small GTPase mediated signal transduction	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	26465210	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24841563	GOA
involved in regulation of actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	24841563	GOA
involved in regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24841563	GOA
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	24841563	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	22891260	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	22891260	GOA
located in cell leading edge	IDA IDA: Inferred from direct assay	21658605	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22891260	GOA
part of exocyst	IDA IDA: Inferred from direct assay	21658605	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	24841563	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22891260	GOA
located in phagocytic cup	IDA IDA: Inferred from direct assay	26465210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3BP1 Protein Structure

BAR

RhoGAP

0
200
400
600
701 a.a.

Protein Preferred Names	Protein Names
SH3 domain-binding protein 1	3BP-1

SH3BP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SH3BP1	Q9Y3L3	TRIP10	Homo sapiens	Q15642-2	Y2H Prey Pooling	32296183
Intra	SH3BP1	Q9Y3L3	TRIP10	Homo sapiens	Q15642-2	Y2H Array	32296183
Intra	SH3BP1	Q9Y3L3	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SH3BP1	Q9Y3L3	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	SH3BP1	Q9Y3L3	TRIP10	Homo sapiens	Q15642	Validated Y2H	25416956
Intra	SH3BP1	Q9Y3L3	FGA	Homo sapiens	P02671-2	Y2H Array	32296183
Intra	SH3BP1	Q9Y3L3	FGA	Homo sapiens	P02671-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12829	SH3BGRL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12830	SH3BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SH3BP1	VGNC	VGNC:34565
Mus musculus	SH3BP1	MGD	MGI:104603
Rattus norvegicus	SH3BP1	RGD	RGD:1306275
Canis familiaris	SH3BP1	VGNC	VGNC:46117
Others	SH3BP1	NCBI