MED28 - mediator complex subunit 28 Gene

Homo sapiens

Also known as EG1; magicin; 1500003D12Rik

Gene ID: 80306 | Gene type: protein coding

About MED28

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,614,641-17,634,105 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in ovary (RPKM 18.1), placenta (RPKM 17.9) and 25 other tissues.

Summary

Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and stem cell population maintenance. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MED28 Products(1)

mRNA	Protein	Name
NM_025205.5	NP_079481.2	mediator of RNA polymerase II transcription subunit 28

MED28 Protein Structure

Med28

0
100
178 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 28

endothelial-derived gene 1

Related Diseases

Diseases

Alias

Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Intellectual Disability-18

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08299	MED28 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MED28	VGNC	VGNC:107347
Rattus norvegicus	MED28	RGD	RGD:1305875
Canis familiaris	MED28	VGNC	VGNC:43135
Macaca mulatta	MED28	VGNC	VGNC:74569
Mus musculus	MED28	MGD	MGI:1914249
Bos taurus	MED28	VGNC	VGNC:31364

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