MED17 - mediator complex subunit 17 Gene

Also Known as SRB4; CRSP6; CRSP77; DRIP80; TRAP80

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9440

About MED17

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:93,784,282-93,814,963 (from NCBI)

This gene has 29 transcripts (splice variants), 206 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 8.7), ovary (RPKM 8.2) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

MED17 Products (1)

mRNA	Protein	Name
NM_004268.5	NP_004259.3	mediator of RNA polymerase II transcription subunit 17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	12218053	GOA
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10198638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12584197	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12037571	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12037571	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	12218053	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9989412	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10198638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10235267	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9989412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED17 Protein Structure

Med17

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651 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 17	ARC77

MED17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	MED17	Q9NVC6	Med30	Mus musculus	Q9CQI9	Pull Down	12584197
Cross	MED17	Q9NVC6	Med30	Mus musculus	Q9CQI9	Anti Tag CoIP	24882805
Intra	MED17	Q9NVC6	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	33961781
Intra	MED17	Q9NVC6	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	24882805
Intra	MED17	Q9NVC6	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	35271311
Intra	MED17	Q9NVC6	MED27	Homo sapiens	Q6P2C8	TAP	24981860
Intra	MED17	Q9NVC6	MED6	Homo sapiens	O75586	Anti Tag CoIP	33961781
Intra	MED17	Q9NVC6	MED6	Homo sapiens	O75586	Anti Tag CoIP	24882805
Intra	MED17	Q9NVC6	MED22	Homo sapiens	Q15528	Anti Tag CoIP	33961781
Intra	MED17	Q9NVC6	MED22	Homo sapiens	Q15528	Pull Down	12584197
Intra	MED17	Q9NVC6	MED22	Homo sapiens	Q15528	TAP	24981860
Intra	MED17	Q9NVC6	MED22	Homo sapiens	Q15528	Anti Tag CoIP	24882805
Intra	MED17	Q9NVC6	MED28	Homo sapiens	Q9H204	TAP	24981860
Intra	MED17	Q9NVC6	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	33961781
Intra	MED17	Q9NVC6	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	35271311
Cross	MED17	Q9NVC6	Med11	Mus musculus	Q9D8C6	Anti Tag CoIP	24882805
Cross	MED17	Q9NVC6	Med8	Mus musculus	Q9D7W5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

MED17 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89973	CRSP77 Antibody (YA9317)	WB, IP	human

Related Diseases

Diseases	Alias
Microcephaly, Postnatal Progressive, With Seizures And Brain Atrophy	Infantile Cerebral And Cerebellar Atrophy With Postnatal Progressive Microcephaly Postnatal Progressive Microcephaly, Seizures, And Brain Atrophy MCPHSBA
Mucinous Adenofibroma
Palindromic Rheumatism	Hench'S Syndrome Hench-Rosenberg Syndrome Palindromic Rheumatism Syndrome Palindromic Arthritis
Microcephaly, Seizures, And Developmental Delay	MCSZ Developmental And Epileptic Encephalopathy 10 Epileptic Encephalopathy, Early Infantile, 10 Eiee10 Dee10 Early Infantile Epileptic Encephalopathy 10
Hermansky-Pudlak Syndrome 3	HPS3 Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Delta Storage Pool Disease Hermansky-Pudlak Syndrome, Type 3 Platelet Storage Pool Deficiency Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Opitz-Kaveggia Syndrome	Fg Syndrome Fgs1 Fgs Keller Syndrome OKS Fg Syndrome 1 Fg Syndrome Type 1 Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08288	MED17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED17	MGD	MGI:2182585
Canis familiaris	MED17	VGNC	VGNC:52266
Rattus norvegicus	MED17	RGD	RGD:1311120
Felis catus	MED17	VGNC	VGNC:103133
Bos taurus	MED17	VGNC	VGNC:56273
Others	MED17	NCBI