MED17 - mediator complex subunit 17 Gene

Homo sapiens

Also known as SRB4; CRSP6; CRSP77; DRIP80; TRAP80

Gene ID: 9440 | Gene type: protein coding

About MED17

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:93,784,282-93,814,963 (from NCBI)

This gene has 29 transcripts (splice variants), 206 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 8.7), ovary (RPKM 8.2) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

MED17 Products(1)

mRNA	Protein	Name
NM_004268.5	NP_004259.3	mediator of RNA polymerase II transcription subunit 17

MED17 Protein Structure

Med17

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651 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 17

ARC77

Related Diseases

Diseases

Alias

Microcephaly, Postnatal Progressive, With Seizures And Brain Atrophy

Infantile Cerebral And Cerebellar Atrophy With Postnatal Progressive Microcephaly	Postnatal Progressive Microcephaly, Seizures, And Brain Atrophy
MCPHSBA

Mucinous Adenofibroma

Palindromic Rheumatism

Hench'S Syndrome	Hench-Rosenberg Syndrome
Palindromic Rheumatism Syndrome	Palindromic Arthritis

Microcephaly, Seizures, And Developmental Delay

MCSZ	Developmental And Epileptic Encephalopathy 10
Epileptic Encephalopathy, Early Infantile, 10	Eiee10
Dee10	Early Infantile Epileptic Encephalopathy 10

Hermansky-Pudlak Syndrome 3

HPS3	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 3
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Opitz-Kaveggia Syndrome

Fg Syndrome	Fgs1
Fgs	Keller Syndrome
OKS	Fg Syndrome 1
Fg Syndrome Type 1	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum
Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08288	MED17 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED17	MGD	MGI:2182585
Canis familiaris	MED17	VGNC	VGNC:52266
Rattus norvegicus	MED17	RGD	RGD:1311120
Felis catus	MED17	VGNC	VGNC:103133
Bos taurus	MED17	VGNC	VGNC:56273

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