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MED22 - mediator complex subunit 22 Gene

Also Known as SRB6; MED24; SURF5; surf-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6837

About MED22

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,338,312-133,348,131 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele and 202 orthologues. Ubiquitous expression in ovary (RPKM 8.5), thyroid (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

MED22 Products (2)

mRNA	Protein	Name
NM_133640.5	NP_598395.1	mediator of RNA polymerase II transcription subunit 22 isoform b
NM_181491.3	NP_852468.1	mediator of RNA polymerase II transcription subunit 22 isoform c

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12584197	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	14638676	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED22 Protein Structure

Med22

0
100
200 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 22	surfeit locus protein 5

MED22 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	MED22	Q15528	Med30	Mus musculus	Q9CQI9	Pull Down	12584197
Intra	MED22	Q15528	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	33961781
Intra	MED22	Q15528	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	24882805
Intra	MED22	Q15528	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	35271311
Intra	MED22	Q15528	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	35271311
Intra	MED22	Q15528	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	33961781
Intra	MED22	Q15528	MED18	Homo sapiens	Q9BUE0	Anti Tag CoIP	24882805
Intra	MED22	Q15528	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	33961781
Intra	MED22	Q15528	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	24882805
Intra	MED22	Q15528	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	35271311
Intra	MED22	Q15528	MED11	Homo sapiens	Q9P086	Anti Tag CoIP	33961781
Intra	MED22	Q15528	MED11	Homo sapiens	Q9P086	Anti Tag CoIP	12584197
Intra	MED22	Q15528	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	35271311
Cross	MED22	Q15528	Med11	Mus musculus	Q9D8C6	Anti Tag CoIP	24882805
Cross	MED22	Q15528	Med8	Mus musculus	Q9D7W5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects	Cornelia De Lange Syndrome 4 CDLS4 Cornelia De Lange Syndrome, Type 4
Trichorhinophalangeal Syndrome, Type Ii	Langer-Giedion Syndrome Lgs Trichorhinophalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome Type 2 TRPS2 Monosomy 8q24.1 Chromosome 8q24.1 Deletion Syndrome Deletion 8q24.1 Giedion-Langer Syndrome Trichorhinophalangeal Dysplasia Type Ii Langer Giedion Syndrome Trps 2 Tricho-Rhino-Phalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome With Exostosis Trps Ii Tricho-Rhino-Phalangeal Syndrome 2 8q24.1 Microdeletion Syndrome 8q24.1 Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08293	MED22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MED22	RGD	RGD:1564893
Mus musculus	MED22	MGD	MGI:98446
Felis catus	MED22	VGNC	VGNC:63437
Bos taurus	MED22	VGNC	VGNC:31359
Canis familiaris	MED22	VGNC	VGNC:43130
Others	MED22	NCBI