MED11 - mediator complex subunit 11 Gene

Also Known as HSPC296

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 400569

About MED11

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,731,428-4,733,607 (from NCBI)

This gene has 4 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in kidney (RPKM 9.3), spleen (RPKM 8.7) and 25 other tissues.

Summary

MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

MED11 Products (2)

mRNA Protein Name
NM_001001683.4 NP_001001683.1 mediator of RNA polymerase II transcription subunit 11 isoform a
NM_001305000.2 NP_001291929.1 mediator of RNA polymerase II transcription subunit 11 isoform b

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12584197 GOA
Cellular Component GO Annotation Evidence References Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
part of mediator complex IDA
IDA: Inferred from direct assay
14638676 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED11 Protein Structure

Med11

Med11: Mediator complex protein (8 - 116)

  • 0
  • 100
  • 117 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 11

  • mediator of RNA polymerase II transcription, subunit 11 homolog

MED11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MED11 Q9P086 MED8 Homo sapiens Q96G25
Crosslink
30021884
Intra
MED11 Q9P086 MED8 Homo sapiens Q96G25
Anti Tag CoIP
35271311
Intra
MED11 Q9P086 MED22 Homo sapiens Q15528
Anti Tag CoIP
12584197
Intra
MED11 Q9P086 MED22 Homo sapiens Q15528
Pull Down
12584197
Intra
MED11 Q9P086 MED22 Homo sapiens Q15528
Anti Tag CoIP
35271311
Intra
MED11 Q9P086 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects

  • Cornelia De Lange Syndrome 4

  • CDLS4

  • Cornelia De Lange Syndrome, Type 4
Luminal Breast Carcinoma A

  • Breast Tumor Luminal

  • Luminal A Breast Carcinoma

  • Luminal Breast Cancer
Trichorhinophalangeal Syndrome, Type Ii

  • Langer-Giedion Syndrome

  • Lgs

  • Trichorhinophalangeal Syndrome Type Ii

  • Trichorhinophalangeal Syndrome Type 2

  • TRPS2

  • Monosomy 8q24.1

  • Chromosome 8q24.1 Deletion Syndrome

  • Deletion 8q24.1

  • Giedion-Langer Syndrome

  • Trichorhinophalangeal Dysplasia Type Ii

  • Langer Giedion Syndrome

  • Trps 2

  • Tricho-Rhino-Phalangeal Syndrome Type Ii

  • Trichorhinophalangeal Syndrome With Exostosis

  • Trps Ii

  • Tricho-Rhino-Phalangeal Syndrome 2

  • 8q24.1 Microdeletion Syndrome

  • 8q24.1 Deletion Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08280 MED11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MED11 RGD RGD:1563202
Felis catus MED11 VGNC VGNC:99222
Bos taurus MED11 VGNC VGNC:31348
Mus musculus MED11 MGD MGI:1913422
Macaca mulatta MED11 VGNC VGNC:74633
Canis familiaris MED11 VGNC VGNC:43119
Others MED11 NCBI