MED27 - mediator complex subunit 27 Gene

Also Known as MED3; CRSP8; CRAP34; CRSP34; TRAP37; NEDSCAC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9442

About MED27

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:131,860,112-132,079,867 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 2.0) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

MED27 Products (3)

mRNA	Protein	Name
NM_001253881.2	NP_001240810.1	mediator of RNA polymerase II transcription subunit 27 isoform 2
NM_001253882.2	NP_001240811.1	mediator of RNA polymerase II transcription subunit 27 isoform 3
NM_004269.4	NP_004260.2	mediator of RNA polymerase II transcription subunit 27 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12584197	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9989412	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9989412	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9989412	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9989412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED27 Protein Structure

Med27

0
100
200
311 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 27	CRSP complex subunit 8

MED27 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	MED27	Q6P2C8	Med30	Mus musculus	Q9CQI9	Pull Down	12584197
Cross	MED27	Q6P2C8	Med30	Mus musculus	Q9CQI9	Anti Tag CoIP	24882805
Intra	MED27	Q6P2C8	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	24882805
Intra	MED27	Q6P2C8	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	35271311
Intra	MED27	Q6P2C8	MED6	Homo sapiens	O75586	Anti Tag CoIP	24882805
Intra	MED27	Q6P2C8	MED6	Homo sapiens	O75586	Anti Tag CoIP	35271311
Intra	MED27	Q6P2C8	MED22	Homo sapiens	Q15528	Anti Tag CoIP	24882805
Intra	MED27	Q6P2C8	MED22	Homo sapiens	Q15528	Anti Tag CoIP	35271311
Intra	MED27	Q6P2C8	MED22	Homo sapiens	Q15528	Pull Down	12584197
Intra	MED27	Q6P2C8	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	24882805
Intra	MED27	Q6P2C8	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	35271311
Cross	MED27	Q6P2C8	Med8	Mus musculus	Q9D7W5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Spasticity, Cataracts, And Cerebellar Hypoplasia	NEDSCAC
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Cerebellar Hypoplasia
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Cerebellar Medulloblastoma
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica
Occupational Dermatitis	Dermatitis, Occupational Occupational Allergic Contact Dermatitis Occupational Eczema
Pneumonic Plague	Primary Pneumonic Plague Secondary Pneumonic Plague Plague Plague, Pneumonic Plague Pneumonia Plague Of Lung Pulmonary Plague Pneumonia Due To Yersinia Pestis
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106398	MED 27		/	Unkown
HY-RS08298	MED27 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED27	MGD	MGI:1916225
Macaca mulatta	MED27	VGNC	VGNC:74563
Felis catus	MED27	VGNC	VGNC:63440
Rattus norvegicus	MED27	RGD	RGD:1564993
Bos taurus	MED27	VGNC	VGNC:31363
Canis familiaris	MED27	VGNC	VGNC:43134
Others	MED27	NCBI