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MED30 - mediator complex subunit 30 Gene

Also Known as MED30S; THRAP6; TRAP25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90390

About MED30

Cytogenetic location: 8q24.11 Genomic coordinates (GRCh38): 8:117,520,713-117,540,262 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 5.0) and 24 other tissues.

Summary

The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]

MED30 Products (3)

mRNA	Protein	Name
NM_001282986.2	NP_001269915.1	mediator of RNA polymerase II transcription subunit 30 isoform 2
NM_001363182.2	NP_001350111.1	mediator of RNA polymerase II transcription subunit 30 isoform 3
NM_080651.4	NP_542382.1	mediator of RNA polymerase II transcription subunit 30 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10198638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21784977	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12218053	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	12218053	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10198638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10235267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED30 Protein Structure

Med30

0
100
178 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 30	TRAP/Mediator complex component TRAP25

MED30 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED30	Q96HR3	DOCK8	Homo sapiens	Q8NF50-2	Y2H Array	25416956
Intra	MED30	Q96HR3	NAP1L2	Homo sapiens	Q9ULW6	Validated Y2H	32296183
Intra	MED30	Q96HR3	MED28	Homo sapiens	Q9H204	TAP	24981860
Intra	MED30	Q96HR3	MED28	Homo sapiens	Q9H204	Validated Y2H	32296183
Intra	MED30	Q96HR3	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	MED30	Q96HR3	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183
Intra	MED30	Q96HR3	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects	Cornelia De Lange Syndrome 4 CDLS4 Cornelia De Lange Syndrome, Type 4
Trichorhinophalangeal Syndrome, Type Ii	Langer-Giedion Syndrome Lgs Trichorhinophalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome Type 2 TRPS2 Monosomy 8q24.1 Chromosome 8q24.1 Deletion Syndrome Deletion 8q24.1 Giedion-Langer Syndrome Trichorhinophalangeal Dysplasia Type Ii Langer Giedion Syndrome Trps 2 Tricho-Rhino-Phalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome With Exostosis Trps Ii Tricho-Rhino-Phalangeal Syndrome 2 8q24.1 Microdeletion Syndrome 8q24.1 Deletion Syndrome
Vestibulocochlear Nerve Disease	Vestibulocochlear Nerve Diseases Acoustic Nerve Disease Cochlear Nerve Diseases Disturbance Of Vestibulocochlear Nerve Auditory Nerve Disorder Disorder Of Acoustovestibular Nerve Disorder Of Eighth Nerve Eighth Cranial Nerve Disorder Disease Of Eighth Cranial Nerve Disease Of Acoustic Nerve Disease Of Auditory Nerve Disorder Of 8th Cranial Nerve Auditory Nerve Lesion Cochlear Nerve Disorder
Vestibular Neuronitis	Vestibular Neuritis Epidemic Neurolabyrinthitis
Herpes Zoster Oticus	Nervus Intermedius Neuralgia Ramsay Hunt Syndrome Type 2 Geniculate Herpes Zoster Geniculate Neuralgia Herpes Zoster Auricularis Herpetic Geniculate Ganglionitis Ramsay Hunt Syndrome Type Ii Ramsey Hunt Syndrome Facial Nerve Palsy Due To Vzv Facial Nerve Palsy Due To Herpes Zoster Infection Facial Nerve Paralysis Due To Vzv Hunt Syndrome Hunt'S Syndrome Ramsay Hunt Syndrome Myoclonus And Ataxia
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08301	MED30 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MED30	VGNC	VGNC:43137
Bos taurus	MED30	VGNC	VGNC:31366
Mus musculus	MED30	MGD	MGI:1917040
Rattus norvegicus	MED30	RGD	RGD:1309369
Macaca mulatta	MED30	VGNC	VGNC:74556
Felis catus	MED30	VGNC	VGNC:63441
Others	MED30	NCBI