MAGI3 - membrane associated guanylate kinase, WW and PDZ domain containing 3 Gene

Also Known as MAGI-3; dJ730K3.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 260425

About MAGI3

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,390,515-113,685,923 (from NCBI)

This gene has 6 transcripts (splice variants), 295 orthologues and 6 paralogues. Broad expression in lung (RPKM 6.5), thyroid (RPKM 5.4) and 24 other tissues.

Summary

Predicted to enable Frizzled binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2022]

MAGI3 Products (2)

mRNA Protein Name
NM_001142782.2 NP_001136254.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1
NM_152900.3 NP_690864.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16316992 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGI3 Protein Structure

Guanylate_kin

Guanylate_kin: Guanylate kinase (129 - 192)

WW

WW: WW domain (295 - 324)

WW

WW: WW domain (341 - 370)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (413 - 477)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (730 - 806)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (852 - 934)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1022 - 1099)

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  • 1200
  • 1481 a.a.
Protein Preferred Names Protein Names

membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

  • membrane-associated guanylate kinase inverted 3

MAGI3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAGI3 Q5TCQ9 ADRB2 Homo sapiens P07550
Anti Tag CoIP
20353789
Intra
MAGI3 Q5TCQ9 ADRB2 Homo sapiens P07550
Pull Down
20353789
Intra
MAGI3 Q5TCQ9 MED28 Homo sapiens Q9H204
Peptide Array
16964398
Intra
MAGI3 Q5TCQ9 ADRB1 Homo sapiens P08588
IF
16316992
Intra
MAGI3 Q5TCQ9 ADRB1 Homo sapiens P08588
Peptide Array
16316992
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07983 MAGI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAGI3 VGNC VGNC:74400
Mus musculus MAGI3 MGD MGI:1923484
Bos taurus MAGI3 VGNC VGNC:31148
Felis catus MAGI3 VGNC VGNC:63366
Canis familiaris MAGI3 VGNC VGNC:42929
Rattus norvegicus MAGI3 RGD RGD:621362