LATS1 - large tumor suppressor kinase 1 Gene

Also Known as wts; WARTS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9113

About LATS1

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,658,153-149,718,101 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues, 13 paralogues and is associated with 96 phenotypes. Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early Mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]

LATS1 Products (5)

mRNA	Protein	Name
NM_001270519.2	NP_001257448.1	serine/threonine-protein kinase LATS1 isoform 2
NM_001350339.2	NP_001337268.1	serine/threonine-protein kinase LATS1 isoform 3
NM_001350340.2	NP_001337269.1	serine/threonine-protein kinase LATS1 isoform 4
NM_001350392.2	NP_001337321.1	serine/threonine-protein kinase LATS1 isoform 5
NM_004690.4	NP_004681.1	serine/threonine-protein kinase LATS1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10518011	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10518011	GOA
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	28068668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9988268	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19927127	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10518011	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	15122335	GOA
involved in cytoplasmic sequestering of protein	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	20412773	GOA
involved in mammary gland epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	28068668	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9988268	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20412773	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10518011	GOA
involved in regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	15220930	GOA
involved in regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28068668	GOA
involved in regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	28068668	GOA
involved in sister chromatid segregation	IDA IDA: Inferred from direct assay	15122335	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	10518011	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LATS1 Protein Structure

UBA

Pkinase

0
200
400
600
800
1000
1130 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase LATS1	LATS (large tumor suppressor, Drosophila) homolog 1

LATS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LATS1	O95835	NF2	Homo sapiens	P35240	Anti Tag CoIP	24012335
Intra	LATS1	O95835	NF2	Homo sapiens	P35240	IF	24012335
Intra	LATS1	O95835	YAP1	Homo sapiens	P46937	ITC	25283809
Intra	LATS1	O95835	NUAK1	Homo sapiens	O60285	Anti Bait CoIP	19927127
Intra	LATS1	O95835	DCAF1	Homo sapiens	Q9Y4B6	Anti Tag CoIP	25026211
Intra	LATS1	O95835	MOB1B	Homo sapiens	Q7L9L4	Pull Down	19739119
Intra	LATS1	O95835	CDK2	Homo sapiens	P24941	Anti Bait CoIP	25218637
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	CoIP	10831611
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	Imaging	10831611
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	Pull Down	10831611
Intra	LATS1	O95835	CDK1	Homo sapiens	P06493	Y2H	9988268
Intra	LATS1	O95835	CDK1	Homo sapiens	P06493	Anti Bait CoIP	25218637
Intra	LATS1	O95835	LIMK1	Homo sapiens	P53667	Pull Down	15220930
Intra	LATS1	O95835	LIMK1	Homo sapiens	P53667	CoIP	15220930
Intra	LATS1	O95835	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	20412773
Intra	LATS1	O95835	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	22078877
Intra	LATS1	O95835	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	19739119
Intra	LATS1	O95835	MOB1A	Homo sapiens	Q9H8S9	Pull Down	19739119
Intra	LATS1	O95835	ESR1	Homo sapiens	P03372	Anti Bait CoIP	28068668

Cross: Cross-species interaction Intra: Intraspecies interaction

LATS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81210	phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rabbit
HY-P86304	LATS1 Antibody (YA5996)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Malignant Peritoneal Mesothelioma	Diffuse Malignant Peritoneal Mesothelioma Primary Malignant Peritoneal Mesothelioma Malignant Mesothelioma Of Peritoneum
Tetraploidy	Tetraploidy Syndrome
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Microphthalmia, Syndromic 10	MCOPS10 Moba Microphthalmia And Brain Atrophy Syndromic Microphthalmia 10 Microphthalmia-Brain Atrophy Syndrome Microphthalmia Syndromic 10 Moba Syndrome Syndromic Microphthalmia Type 10
Metatypical Basal Cell Carcinoma	Skin Metatypical Carcinoma Basosquamous Carcinoma Of Skin Skin Metatypical Basal Cell Carcinoma
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14889	Fluciclovine		/	Unkown

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138489	TRULI	Inhibitor	99.98%	Unkown
HY-108540	BCH	Inducer	99.83%	Unkown
HY-147082	GA-017		98.95%	Unkown
HY-W011391	GPNA hydrochloride		99.91%	Unkown
HY-W087830	L-p-Boronophenylalanine		99.84%	Unkown
HY-120139	KMH-233	Inhibitor	99.75%	Unkown
HY-147165	VT02956	Inhibitor	99.58%	Unkown
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-176886	LATS-IN-2	Inhibitor	99.45%	Unkown
HY-164254	Cardiomyocyte proliferation promoting agent-1	Inhibitor	99.87%	Unkown
HY-175247	DDO-4033		99.11%	Unkown
HY-W267524	H-Phe(3-CF3)-OH		/	Unkown
HY-120139A	(R)-KMH-233	Control	/	Unkown
HY-183513	L-Ala-BPA	Substrate	/	Unkown
HY-RS07538	LATS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-108540R	BCH (Standard)	Inducer	99.84%	Unkown
HY-147165A	VT02956 hydrochloride	Inhibitor	/	Unkown
HY-164401	QBS10072S	Inducer	/	Unkown
HY-164401A	QBS10072S dihydrochloride		/	Unkown
HY-175649	LATS1/2-IN-1	Inhibitor	/	Unkown
HY-181743	Piezo1 agonist 2	Agonist	/	Unkown
HY-182254	AChE/BChE-IN-35	Inhibitor	/	Unkown
HY-183147A	LAT1-IN-2 hydrochloride	Substrate	/	Unkown
HY-RS17343	Lats1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23797	Lats1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W246010	α,α-DiBn-DL-Gly	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LATS1	VGNC	VGNC:74238
Felis catus	LATS1	VGNC	VGNC:68021
Canis familiaris	LATS1	VGNC	VGNC:42598
Bos taurus	LATS1	VGNC	VGNC:30800
Rattus norvegicus	LATS1	RGD	RGD:1564085
Mus musculus	LATS1	MGD	MGI:1333883
Others	LATS1	NCBI