2. Gene
  3. LATS1 - large tumor suppressor kinase 1 Gene

LATS1 - large tumor suppressor kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as wts; WARTS

Gene ID: 9113 | Gene type: protein coding

About LATS1

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,658,153-149,718,101 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues, 13 paralogues and is associated with 96 phenotypes. Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]

LATS1 Products(5)

mRNA Protein Name
NM_001270519.2 NP_001257448.1 serine/threonine-protein kinase LATS1 isoform 2
NM_001350339.2 NP_001337268.1 serine/threonine-protein kinase LATS1 isoform 3
NM_001350340.2 NP_001337269.1 serine/threonine-protein kinase LATS1 isoform 4
NM_001350392.2 NP_001337321.1 serine/threonine-protein kinase LATS1 isoform 5
NM_004690.4 NP_004681.1 serine/threonine-protein kinase LATS1 isoform 1

LATS1 Protein Structure

UBA

UBA: UBA/TS-N domain (102 - 138)

Pkinase

Pkinase: Protein kinase domain (706 - 859)

Pkinase

Pkinase: Protein kinase domain (906 - 1010)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1130 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase LATS1

LATS (large tumor suppressor, Drosophila) homolog 1

Related Diseases

Diseases Alias
Malignant Peritoneal Mesothelioma

Diffuse Malignant Peritoneal Mesothelioma

Primary Malignant Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum
Tetraploidy

Tetraploidy Syndrome
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Neurofibromatosis, Type Ii

Neurofibromatosis 2

Neurofibromatosis, Type 2

NF2

Neurofibromatosis Type Ii

Bilateral Acoustic Neurofibromatosis

Banf

Acn

Central Neurofibromatosis

Neurofibromatosis, Central Type

Acoustic Schwannomas, Bilateral

Acoustic Neurinoma, Bilateral

Bilateral Acoustic Neurinoma

Bilateral Acoustic Schwannomas

Familial Acoustic Neuromas
Microphthalmia, Syndromic 10

MCOPS10

Moba

Microphthalmia And Brain Atrophy

Syndromic Microphthalmia 10

Microphthalmia-Brain Atrophy Syndrome

Microphthalmia Syndromic 10

Moba Syndrome

Syndromic Microphthalmia Type 10
Metatypical Basal Cell Carcinoma

Skin Metatypical Carcinoma

Basosquamous Carcinoma Of Skin

Skin Metatypical Basal Cell Carcinoma
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138489 TRULI Modulator 99.98% Unkown
HY-108540 BCH Inducer ≥98.0% Unkown
HY-147082 GA-017 Activator 98.92% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-139330 MGH-CP1 Inducer 99.21% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-120139 KMH-233 Inhibitor 98.11% Unkown
HY-120139A (R)-KMH-233 / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LATS1 VGNC VGNC:74238
Felis catus LATS1 VGNC VGNC:68021
Canis familiaris LATS1 VGNC VGNC:42598
Bos taurus LATS1 VGNC VGNC:30800
Rattus norvegicus LATS1 RGD RGD:1564085
Mus musculus LATS1 MGD MGI:1333883