NUAK1 - NUAK family kinase 1 Gene

Homo sapiens

Also known as ARK5

Gene ID: 9891 | Gene type: protein coding

About NUAK1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,063,345-106,138,954 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 17 paralogues. Broad expression in brain (RPKM 19.6), skin (RPKM 9.2) and 19 other tissues.

Summary

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

NUAK1 Products(1)

mRNA	Protein	Name
NM_014840.3	NP_055655.1	NUAK family SNF1-like kinase 1

NUAK1 Protein Structure

Pkinase

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

NUAK family SNF1-like kinase 1

AMP-activated protein kinase family member 5	AMPK-related protein kinase 5
NUAK family, SNF1-like kinase, 1	omphalocele kinase 1

Related Diseases

Diseases

Alias

Omphalocele

Omphalocoele	Congenital Omphalocele
Exomphalos	Exumbilication

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Endometrial Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Endometrium

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12624	Narazaciclib	Inhibitor	99.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15802	WZ4003	Inhibitor	98.88%	Unkown
HY-12334	HTH-01-015	Inhibitor	98.81%	Unkown
HY-120877	MRT199665	Inhibitor	99.92%	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NUAK1	VGNC	VGNC:75403
Rattus norvegicus	NUAK1	RGD	RGD:1309956
Bos taurus	NUAK1	VGNC	VGNC:50006
Mus musculus	NUAK1	MGD	MGI:1925226
Canis familiaris	NUAK1	VGNC	VGNC:54977
Others	NUAK1	NCBI

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