2. Epigenetics PI3K/Akt/mTOR Cell Cycle/DNA Damage
  3. AMPK CDK
  4. ARUK2010489

ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7. ARUK2010489 also inhibits CDK2, CDK4 and CDK6 activity, with inhibitory rate of 7%, 39% and 26% at 1 μM. ARUK2010489 can be used for the research of neurological disease, such as Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

ARUK2010489

ARUK2010489 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

ARUK2010489 Related Antibodies

Top Publications Citing Use of Products

View All AMPK Isoform Specific Products:

View All Isoforms
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7. ARUK2010489 also inhibits CDK2, CDK4 and CDK6 activity, with inhibitory rate of 7%, 39% and 26% at 1 μM. ARUK2010489 can be used for the research of neurological disease, such as Alzheimer’s disease (AD)[1].

IC50 & Target[1]

NUAK1

8.7 (pIC50)

CDK2

 

CDK4

 

CDK6

 

Parmacokinetics
Species Dose Route T1/2 AUCinf Brain-to-Plasma Ratio
Mice[1] 5 mg/kg i.p. 1.2 h 988 ng·h/mL 7.6/9.4
Molecular Weight

406.52

Formula

C23H30N6O
Appearance

Solid

Color

White to light yellow

SMILES

CC(N1CCN(C2=CC=C(NC3=NC(OCC4CC4)=C5C(NC=C5)=N3)C=C2)CC1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (245.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4599 mL 12.2995 mL 24.5990 mL
5 mM 0.4920 mL 2.4599 mL 4.9198 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4599 mL 12.2995 mL 24.5990 mL 61.4976 mL
5 mM 0.4920 mL 2.4599 mL 4.9198 mL 12.2995 mL
10 mM 0.2460 mL 1.2300 mL 2.4599 mL 6.1498 mL
15 mM 0.1640 mL 0.8200 mL 1.6399 mL 4.0998 mL
20 mM 0.1230 mL 0.6150 mL 1.2300 mL 3.0749 mL
25 mM 0.0984 mL 0.4920 mL 0.9840 mL 2.4599 mL
30 mM 0.0820 mL 0.4100 mL 0.8200 mL 2.0499 mL
40 mM 0.0615 mL 0.3075 mL 0.6150 mL 1.5374 mL
50 mM 0.0492 mL 0.2460 mL 0.4920 mL 1.2300 mL
60 mM 0.0410 mL 0.2050 mL 0.4100 mL 1.0250 mL
80 mM 0.0307 mL 0.1537 mL 0.3075 mL 0.7687 mL
100 mM 0.0246 mL 0.1230 mL 0.2460 mL 0.6150 mL
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ARUK2010489 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARUK2010489ARUK 2010489ARUK-2010489AMPKCDKAMP-activated protein kinaseCyclin dependent kinaseNUAK1Kinase selectivityADME propertiesAlzheimer’s disease (AD)CDK2CDK4CDK6Inhibitorinhibitorinhibit

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