ARUK2010694
ARUK2010694 (Compound 20) is a potent and selective NUAK1 inhibitor with a pIC50 of 8.7. ARUK2010694 also inhibits CDK2, CDK4 and CDK6 activity, with inhibitory rate of 13%, 63% and 32% at 1 μM. ARUK2010694 can be used for the research of neurological disease, such as Alzheimer’s disease (AD).
For research use only. We do not sell to patients.
- Formula: C26H37N7O2
- Molecular Weight:479.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
|
NUAK1 8.7 (pIC50) |
CDK2 |
CDK4 |
CDK6 |
| Species | Dose | Route | T1/2 | AUCinf | Brain-to-Plasma Ratio |
|---|---|---|---|---|---|
| Mice[1] | 5 mg/kg | i.p. | 1.6 h | 1015 ng·h/mL | 0.1/0.2 |
Chemical Information
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Molecular Weight 479.62
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Formula C26H37N7O2
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SMILES
CC(N1CCN(C2=CC=C(NC3=NC(OCC4CC(C)(C)OCC4)=C5N=CNC5=N3)C=C2)CC1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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