YAP1 - Yes1 associated transcriptional regulator Gene

Also Known as YAP; YKI; COB1; YAP2; YAP-1; YAP65

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10413

About YAP1

Cytogenetic location: 11q22.1 Genomic coordinates (GRCh38): 11:102,110,447-102,233,424 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues, 1 paralogue and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 45.0), endometrium (RPKM 38.7) and 23 other tissues.

Summary

This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for Cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

YAP1 Products (14)

mRNA	Protein	Name
XM_011542555.3	XP_011540857.1	transcriptional coactivator YAP1 isoform X5
NM_001282097.2	NP_001269026.1	transcriptional coactivator YAP1 isoform 6
NM_001195044.2	NP_001181973.1	transcriptional coactivator YAP1 isoform 3
XM_005271378.4	XP_005271435.1	transcriptional coactivator YAP1 isoform X1
NM_006106.5	NP_006097.2	transcriptional coactivator YAP1 isoform 2
XM_005271381.4	XP_005271438.1	transcriptional coactivator YAP1 isoform X3
NM_001282100.2	NP_001269029.1	transcriptional coactivator YAP1 isoform 8
NM_001282098.2	NP_001269027.1	transcriptional coactivator YAP1 isoform 5
NM_001282101.2	NP_001269030.1	transcriptional coactivator YAP1 isoform 9
NM_001195045.2	NP_001181974.1	transcriptional coactivator YAP1 isoform 4
XM_005271380.4	XP_005271437.1	transcriptional coactivator YAP1 isoform X2
NM_001130145.3	NP_001123617.1	transcriptional coactivator YAP1 isoform 1
XM_005271383.4	XP_005271440.1	transcriptional coactivator YAP1 isoform X4
NM_001282099.2	NP_001269028.1	transcriptional coactivator YAP1 isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20123905	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7644498	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18280240	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16772533	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	20123905	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	18158288	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	18158288	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	18280240	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	18280240	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	35429439	GOA
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25849865	GOA
involved in negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	29403552	GOA
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	29496737	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	29403552	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25849865	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20368466	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20123905	GOA
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	17974916	GOA
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	29403552	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	29403552	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	29496737	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20123905	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	20368466	GOA
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	20123905	GOA
acts upstream of or within regulation of neurogenesis	IDA IDA: Inferred from direct assay	25433207	GOA
acts upstream of or within regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	25433207	GOA
involved in response to progesterone	IDA IDA: Inferred from direct assay	16772533	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TEAD-YAP complex	IDA IDA: Inferred from direct assay	20123905	GOA
part of TEAD-YAP complex	IPI IPI: Inferred from physical interaction	25384421	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17974916	GOA
located in cytosol	IDA IDA: Inferred from direct assay	30865227	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	35429439	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17974916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YAP1 Protein Structure

0
100
200
300
400
504 a.a.

Protein Preferred Names	Protein Names
transcriptional coactivator YAP1	65 kDa Yes-associated protein Yes associated protein 1 protein yorkie homolog yes-associated protein 2 yes-associated protein YAP65 homolog yorkie homolog

YAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	YAP1	P46937	NHERF2	Homo sapiens	Q15599	Anti Tag CoIP	24255178
Intra	YAP1	P46937	PRKAA1	Homo sapiens	Q13131	Anti Tag CoIP	25751140
Intra	YAP1	P46937	PRKAA1	Homo sapiens	Q13131	TAP	25751139
Intra	YAP1	P46937	PTPN14	Homo sapiens	Q15678	Anti Tag CoIP	24255178
Intra	YAP1	P46937	PTPN14	Homo sapiens	Q15678	Anti Tag CoIP	24366813
Intra	YAP1	P46937	PTPN14	Homo sapiens	Q15678	ITC	25283809
Intra	YAP1	P46937	PTPN14	Homo sapiens	Q15678	TAP	25751139
Intra	YAP1	P46937	SMAD1	Homo sapiens	Q15797	ITC	19914168
Intra	YAP1	P46937	SMAD1	Homo sapiens	Q15797	Anti Tag CoIP	19914168
Intra	YAP1	P46937	TP63	Homo sapiens	Q9H3D4	Phage Display	35044719
Cross	YAP1	P46937	Axin1	Mus musculus	O35625	Anti Tag CoIP	24976009
Intra	YAP1	P46937	TP53BP2	Homo sapiens	Q13625-2	Peptide Array	11278422
Intra	YAP1	P46937	TP53BP2	Homo sapiens	Q13625-2	Y2H	11278422
Intra	YAP1	P46937	UVRAG	Homo sapiens	Q9P2Y5	Phage Display	37219487
Intra	YAP1	P46937	UVRAG	Homo sapiens	Q9P2Y5	Phage Display	35044719
Intra	YAP1	P46937	TBX5	Homo sapiens	Q99593	CH-IP	23245941
Intra	YAP1	P46937	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	24976009
Intra	YAP1	P46937	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	24255178
Intra	YAP1	P46937	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	YAP1	P46937	TRERF1	Homo sapiens	Q96PN7	Phage Display	37219487
Intra	YAP1	P46937	TRERF1	Homo sapiens	Q96PN7	Phage Display	35044719
Intra	YAP1	P46937	YWHAE	Homo sapiens	P62258	TAP	25751139
Intra	YAP1	P46937	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	24255178
Intra	YAP1	P46937	YWHAE	Homo sapiens	P62258	Pull Down	25751139
Intra	YAP1	P46937	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	24366813
Intra	YAP1	P46937	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	24255178
Intra	YAP1	P46937	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	19439659
Intra	YAP1	P46937	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	24366813
Intra	YAP1	P46937	YWHAB	Homo sapiens	P31946	CoIP	20048001
Intra	YAP1	P46937	SMAD7	Homo sapiens	O15105	ITC	25283809
Intra	YAP1	P46937	WBP1	Homo sapiens	Q96G27	Phage Display	35044719
Intra	YAP1	P46937	WBP1	Homo sapiens	Q96G27	ITC	25283809
Intra	YAP1	P46937	TP73	Homo sapiens	O15350	ITC	25283809
Intra	YAP1	P46937	TP73	Homo sapiens	O15350	Phage Display	37219487
Intra	YAP1	P46937	TP73	Homo sapiens	O15350	Phage Display	35044719
Intra	YAP1	P46937	TP73	Homo sapiens	O15350-1	Anti Bait CoIP	11278685
Intra	YAP1	P46937	TP73	Homo sapiens	O15350-1	Lambda Phage	11278685
Intra	YAP1	P46937	PRRG4	Homo sapiens	Q9BZD6	Phage Display	37219487
Intra	YAP1	P46937	PRRG4	Homo sapiens	Q9BZD6	Phage Display	35044719
Intra	YAP1	P46937	LATS1	Homo sapiens	O95835	Phage Display	35044719
Intra	YAP1	P46937	LATS1	Homo sapiens	O95835	ITC	25283809
Intra	YAP1	P46937	LATS1	Homo sapiens	O95835	Anti Tag CoIP	24366813
Intra	YAP1	P46937	LATS1	Homo sapiens	O95835	Protein Kinase Assay	22863277
Intra	YAP1	P46937	LATS1	Homo sapiens	O95835	TAP	25751139
Intra	YAP1	P46937	LATS1	Homo sapiens	O95835	Anti Tag CoIP	24255178
Intra	YAP1	P46937	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	22234184
Intra	YAP1	P46937	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	24976009
Intra	YAP1	P46937	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	21376238
Intra	YAP1	P46937	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	23245941
Intra	YAP1	P46937	CTNNB1	Homo sapiens	P35222	Pull Down	22234184
Intra	YAP1	P46937	MAP2K1	Homo sapiens	Q02750	Anti Tag CoIP	24211253
Intra	YAP1	P46937	TEAD1	Homo sapiens	P28347	Anti Tag CoIP	25751140
Intra	YAP1	P46937	TEAD1	Homo sapiens	P28347	BioID	24255178
Intra	YAP1	P46937	TEAD1	Homo sapiens	P28347	Anti Bait CoIP	24581491
Intra	YAP1	P46937	TEAD1	Homo sapiens	P28347	Anti Bait CoIP	25751140
Intra	YAP1	P46937	TEAD1	Homo sapiens	P28347	Anti Bait CoIP	22863277
Intra	YAP1	P46937	TEAD1	Homo sapiens	P28347	TAP	25751139
Cross	YAP1	P46937	Wbp1	Mus musculus	P97764	Filter Binding	7644498
Cross	YAP1	P46937	Wbp1	Mus musculus	P97764	Filter Binding	9202023
Intra	YAP1	P46937	TEAD2	Homo sapiens	Q15562	TAP	25751139
Intra	YAP1	P46937	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	24976009
Intra	YAP1	P46937	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	24976009
Intra	YAP1	P46937	TMEM139	Homo sapiens	Q8IV31	Phage Display	35044719
Intra	YAP1	P46937	WBP2	Homo sapiens	Q969T9	Anti Tag CoIP	24366813
Intra	YAP1	P46937	WBP2	Homo sapiens	Q969T9	Anti Tag CoIP	24255178
Intra	YAP1	P46937	WBP2	Homo sapiens	Q969T9	TAP	25751139
Intra	YAP1	P46937	WBP2	Homo sapiens	Q969T9	ITC	25283809
Cross	YAP1	P46937	Prkaa1	Mus musculus	Q5EG47	Pull Down	25751139
Intra	YAP1	P46937	RAB11A	Homo sapiens	P62491	Anti Bait CoIP	28468127
Intra	YAP1	P46937	DDX17	Homo sapiens	Q92841	IF	24581491
Intra	YAP1	P46937	DDX17	Homo sapiens	Q92841	Anti Bait CoIP	24581491
Intra	YAP1	P46937	DDX17	Homo sapiens	Q92841	Anti Tag CoIP	24581491
Intra	YAP1	P46937	TEAD4	Homo sapiens	Q15561	Anti Bait CoIP	24525233
Intra	YAP1	P46937	TEAD4	Homo sapiens	Q15561	Pull Down	24525233
Intra	YAP1	P46937	TEAD4	Homo sapiens	Q15561	Anti Tag CoIP	25751140
Intra	YAP1	P46937	TEAD4	Homo sapiens	Q15561	Pull Down	25751139
Intra	YAP1	P46937	ERBB4	Homo sapiens	Q15303	ITC	25283809
Intra	YAP1	P46937	PTCH1	Homo sapiens	Q13635	ITC	25283809
Intra	YAP1	P46937	TEAD2	Homo sapiens	Q15562-2	Validated Y2H	32296183
Intra	YAP1	P46937	PRRG2	Homo sapiens	O14669	ITC	25283809
Cross	YAP1	P46937	M	Rabies virus	A3RM21	Phage Display	37100772

Cross: Cross-species interaction Intra: Intraspecies interaction

YAP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80374	YAP1 Antibody	WB, ICC/IF, IHC-P, IP, FC	Human
HY-P80481	Phospho-YAP1 (Ser127) Antibody (YA137)	WB, IHC-P	Human, Mouse
HY-P80864	Phospho-YAP1 (Ser127) Antibody (YA136)	WB, IHC-P	Human, Mouse, Rat
HY-P80864A	Phospho-YAP1 (Ser127) Antibody (YA136)(PBS only)	WB, IHC-P	Human, Mouse, Rat
HY-P84342	YAP1 Antibody (YA4039)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P84342A	YAP1 Antibody (YA4039)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P86167	Phospho-YAP1(Ser127) Antibody (YA5859)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86386	YAP1 Antibody (YA6078)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
High Grade Ependymoma	Ependymal Neoplasm Ependymal Tumors Malignant Ependymoma Ependymal Tumor Anaplastic Ependymoma Experimental Organism Malignant Ependymoma Ependymoma Of Brain
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Eccrine Porocarcinoma	Eccrine Porocarcinoma Of Skin Malignant Eccrine Poroma Porocarcinoma
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Neurofibroma	Neurofibromas Neurofibromatoses Nerve Sheath Tumors
Cleft Lip/Palate	Cleft Lip And Palate Alveolar Cleft Lip And Palate Cleft Lip-Alveolus-Palate Syndrome Flp
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Epithelioid Hemangioendothelioma	Hemangioendothelioma Epithelioid Epithelioid Hemangioendothelioma, Malignant
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Cerebral Ventricle Cancer	Cerebral Ventricle Neoplasms Cerebral Ventricle Neoplasm Intraventricular Tumor Of Brain
Spinocerebellar Ataxia 45	SCA45 Spinocerebellar Ataxia Type 45
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Rela Fusion-Positive Ependymoma	Supratentorial C11orf95-Rela Fused Ependymoma C11orf95 Fusion-Positive Supratentorial Ependymoma
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Cavernous Angioma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Childhood Angiosarcoma	Paediatric Angiosarcoma Paediatric Hemangiosarcoma Pediatric Angiosarcoma Pediatric Hemangiosarcoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Pilomatrixoma	Pilomatricoma PTR Epithelioma Calcificans Of Malherbe Benign Pilomatricoma Calcifying Epithelioma Of Malherbe Pilomatricoma, Somatic Benign Pilomatrixoma Malherbe Calcifying Epithelioma
Cystadenocarcinoma
Hepatoblastoma
Posterior Fossa Ependymoma
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Spinal Cord Ependymoma	Ependymal Neoplasm Of The Spinal Cord Ependymoma Of Spinal Cord
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Supratentorial Ependymoma
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Anaplastic Ependymoma	Ependymoma, Anaplastic Undifferentiated Ependymoma
Rhabdomyosarcoma
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Coloboma, Ocular, Autosomal Dominant	Coloboma, Ocular Coloboma Of Iris, Choroid, And Retina Coi Coloboma, Uveoretinal COAD Ocular Coloboma Uveoretinal Coloboma Chronic Obstructive Airway Disease
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Childhood Supratentorial Ependymoma	Paediatric Cerebral Ependymoma Paediatric Supratentorial Ependymoblastoma Paediatric Supratentorial Ependymoma Pediatric Cerebral Ependymoma Pediatric Supratentorial Ependymoblastoma Pediatric Supratentorial Ependymoma
Eccrine Acrospiroma	Acrospiroma Poroma Eccrine Hidradenoma Eccrine Hidradenoma Of Skin Hidradenoma Adenoma, Sweat Gland Benign Neoplasm Of Sweat Gland Eccrine Poroma
Histiocytoid Hemangioma	Angiolymphoid Hyperplasia With Eosinophilia Epithelioid Haemangioma Epithelioid Hemangioma
Eccrine Sweat Gland Cancer	Malignant Eccrine Skin Neoplasm Malignant Eccrine Tumor
Eccrine Sweat Gland Neoplasm	Eccrine Skin Neoplasm Eccrine Tumor Eccrine Neoplasm Malignant Eccrine Neoplasm
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Mental Retardation	Uveal Coloboma-Cleft Lip And Palate-Intellectual Disability COB1 Coloboma-Microphthalmos Syndrome Coloboma-Microphthalmos Syndrome Associated With Sensorineural Hearing Loss, Hematuria, And Cleft Lip/Palate Uveal Coloboma-Cleft Lip/Palate-Mental Retardation Syndrome Coloboma, Cleft Lip-Palate And Mental Retardation Syndrome Ocular Coloboma With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Mental Retardation Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Intellectual Disability Coloboma, Ocular, With/Without Hearing Impairment, Cleft Lip/Palate, And/Or Mental Retardation
Spinal Ependymoma, Mycn
Myxopapillary Ependymoma	Ependymoma Myxopapillary
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176542	TD034	Inhibitor	99.77%	Unkown
HY-175649	LATS1/2-IN-1	Inhibitor	/	Unkown
HY-E70293	N-Acetylgalactosaminyltransferase 12		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	YAP1	RGD	RGD:1306035
Mus musculus	YAP1	MGD	MGI:103262
Felis catus	YAP1	VGNC	VGNC:105820
Macaca mulatta	YAP1	VGNC	VGNC:79018
Bos taurus	YAP1	VGNC	VGNC:57367
Canis familiaris	YAP1	VGNC	VGNC:49698
Others	YAP1	NCBI