PTPN14 - protein tyrosine phosphatase non-receptor type 14 Gene

Also Known as PEZ; PTP36; PTPD2; CATLPH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5784

About PTPN14

Cytogenetic location: 1q32.3-q41 Genomic coordinates (GRCh38): 1:214,348,700-214,551,602 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues, 35 paralogues and is associated with 3 phenotypes. Ubiquitous expression in skin (RPKM 9.0), kidney (RPKM 5.5) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or Cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

PTPN14 Products (1)

mRNA Protein Name
NM_005401.5 NP_005392.2 tyrosine-protein phosphatase non-receptor type 14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22525271 GOA
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
22525271 GOA
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
20826270 GOA
enables transcription coregulator activity IMP
IMP: Inferred from mutant phenotype
22525271 GOA
Biological Process GO Annotation Evidence References Source
involved in lymphangiogenesis IMP
IMP: Inferred from mutant phenotype
20826270 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
22948661 GOA
involved in regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
22948661 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10934049 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10934049 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN14 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (25 - 103)

FERM_M

FERM_M: FERM central domain (109 - 220)

FERM_C

FERM_C: FERM C-terminal PH-like domain (224 - 306)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (933 - 1178)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1187 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 14

  • cytoskeletal-associated protein tyrosine phosphatase

PTPN14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPN14 Q15678 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
Intra
PTPN14 Q15678 YAP1 Homo sapiens P46937
ITC
25283809
Intra
PTPN14 Q15678 AMOT Homo sapiens A2BDD9
Y2H Prey Pooling
32296183
Intra
PTPN14 Q15678 AMOT Homo sapiens A2BDD9
Y2H Array
32296183
Intra
PTPN14 Q15678 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
PTPN14 Q15678 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PTPN14 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84597 PTPN14 Antibody (YA4294) IHC-P, ICC/IF, FC, ELISA Human
HY-P84597A PTPN14 Antibody (YA4294)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Choanal Atresia And Lymphedema

  • Lymphedema-Posterior Choanal Atresia Syndrome

  • CATLPH

  • Atresia, Choanal, And Lymphedema
Esophageal Atresia

  • Tracheoesophageal Fistula

  • Congenital Atresia Of Esophagus

  • Congenital Imperforate Esophagus

  • Imperforate Esophagus

  • Oesophageal Atresia

  • Te Fistula

  • Tef

  • Tracheoesophageal Fistula With Or Without Esophageal Atresia
Leopard Syndrome 2

  • LPRD2

  • Noonan Syndrome With Multiple Lentigines 2

  • Leopard Syndrome, Type 2
Metatypical Basal Cell Carcinoma

  • Skin Metatypical Carcinoma

  • Basosquamous Carcinoma Of Skin

  • Skin Metatypical Basal Cell Carcinoma
Noonan Syndrome 5

  • NS5

  • Noonan Syndrome, Type 5
Noonan Syndrome 3

  • NS3

  • Noonan Syndrome, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11419 PTPN14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21181 Ptpn14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPN14 MGD MGI:102467
Bos taurus PTPN14 VGNC VGNC:33532
Canis familiaris PTPN14 VGNC VGNC:45171
Rattus norvegicus PTPN14 RGD RGD:1307885
Macaca mulatta PTPN14 VGNC VGNC:76600
Felis catus PTPN14 VGNC VGNC:69161
Others PTPN14 NCBI