TRIP6 - thyroid hormone receptor interactor 6 Gene

Also Known as OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7205

About TRIP6

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,867,387-100,873,454 (from NCBI)

This gene has 9 transcripts (splice variants), 107 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 26.6), kidney (RPKM 24.0) and 25 other tissues.

Summary

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

TRIP6 Products (1)

mRNA	Protein	Name
NM_003302.3	NP_003293.2	thyroid receptor-interacting protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-1 receptor binding	IDA IDA: Inferred from direct assay	15657077	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	15657077	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10826496	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	14688263	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15657077	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoskeleton	IDA IDA: Inferred from direct assay	16624523	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	14688263	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10826496	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP6 Protein Structure

LIM

0
100
200
300
400
476 a.a.

Protein Preferred Names	Protein Names
thyroid receptor-interacting protein 6	OPA-interacting protein 1

TRIP6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIP6	Q15654	ZBP1	Homo sapiens	A2RRL9	Y2H Array	25416956
Intra	TRIP6	Q15654	ZBP1	Homo sapiens	A2RRL9	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	TRIP6	Q15654	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	25416956
Intra	TRIP6	Q15654	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	TRIP6	Q15654	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	TRIP6	Q15654	TPM3	Homo sapiens	Q5VU62	Y2H Array	25416956
Intra	TRIP6	Q15654	TPM3	Homo sapiens	Q5VU62	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	CTAG2	Homo sapiens	O75638	Y2H Array	31515488
Intra	TRIP6	Q15654	CTAG2	Homo sapiens	O75638	Y2H Array	25416956
Intra	TRIP6	Q15654	CTAG2	Homo sapiens	O75638	Validated Y2H	25416956
Intra	TRIP6	Q15654	CREB5	Homo sapiens	Q02930-3	Validated Y2H	25416956
Intra	TRIP6	Q15654	SLC15A3	Homo sapiens	Q05CH4	Y2H Array	25416956
Intra	TRIP6	Q15654	WT1-AS	Homo sapiens	Q06250	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	WT1-AS	Homo sapiens	Q06250	Validated Y2H	25416956
Intra	TRIP6	Q15654	TMSB4X	Homo sapiens	Q0P5Q0	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	TMSB4X	Homo sapiens	Q0P5Q0	Validated Y2H	25416956
Intra	TRIP6	Q15654	HYKK	Homo sapiens	A0A0C4DGM4	Validated Y2H	25416956
Intra	TRIP6	Q15654	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	TRIP6	Q15654	POM121L1P	Homo sapiens	Q3SYA9	Validated Y2H	25416956
Intra	TRIP6	Q15654	POM121L1P	Homo sapiens	Q3SYA9	Y2H Array	25416956
Intra	TRIP6	Q15654	POM121L1P	Homo sapiens	Q3SYA9	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	yt011_human	Homo sapiens	Q5W150	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	RNF213	Homo sapiens	Q63HN8-6	Y2H Array	25416956
Intra	TRIP6	Q15654	VASN	Homo sapiens	Q6EMK4	Validated Y2H	32296183
Intra	TRIP6	Q15654	NR1D2	Homo sapiens	Q6NSM0	Validated Y2H	32296183
Intra	TRIP6	Q15654	XRCC6BP1	Homo sapiens	Q8N4L5	Validated Y2H	25416956
Intra	TRIP6	Q15654	NEU4	Homo sapiens	Q8WWR8-2	Y2H Array	25416956
Intra	TRIP6	Q15654	NEU4	Homo sapiens	Q8WWR8-2	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	NEU4	Homo sapiens	Q8WWR8-2	Validated Y2H	25416956
Intra	TRIP6	Q15654	KIR2DL4	Homo sapiens	Q99706	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	KIR2DL4	Homo sapiens	Q99706	Validated Y2H	25416956
Intra	TRIP6	Q15654	KIR2DL4	Homo sapiens	Q99706	Y2H Array	25416956
Intra	TRIP6	Q15654	OTUB2	Homo sapiens	Q9BWI9	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	OTUB2	Homo sapiens	Q9BWI9	Validated Y2H	25416956
Intra	TRIP6	Q15654	OTUB2	Homo sapiens	Q9BWI9	Y2H Array	25416956
Intra	TRIP6	Q15654	HEL-S-42	Homo sapiens	V9HWD0	Y2H Array	25416956
Intra	TRIP6	Q15654	HEL-S-42	Homo sapiens	V9HWD0	Validated Y2H	25416956
Intra	TRIP6	Q15654	SNAI1	Homo sapiens	O95863	Y2H Array	31515488
Intra	TRIP6	Q15654	CNTF	Homo sapiens	P26441	Y2H Array	25416956
Intra	TRIP6	Q15654	IP6K3	Homo sapiens	Q96PC2	Validated Y2H	32296183
Intra	TRIP6	Q15654	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	TRIP6	Q15654	MEMO1	Homo sapiens	Q9Y316	Validated Y2H	25416956
Intra	TRIP6	Q15654	MEMO1	Homo sapiens	Q9Y316	Y2H Array	25416956
Intra	TRIP6	Q15654	MEMO1	Homo sapiens	Q9Y316	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	CCDC24	Homo sapiens	Q8N4L8	Validated Y2H	32296183
Intra	TRIP6	Q15654	FOXD4L1	Homo sapiens	Q9NU39	Validated Y2H	32296183
Intra	TRIP6	Q15654	PRKAA1	Homo sapiens	Q13131	Y2H Array	25416956
Intra	TRIP6	Q15654	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
Intra	TRIP6	Q15654	ZIC1	Homo sapiens	Q15915	Validated Y2H	32296183
Intra	TRIP6	Q15654	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	TRIP6	Q15654	PLEKHN1	Homo sapiens	Q494U1-3	Validated Y2H	32296183
Intra	TRIP6	Q15654	RANBP3L	Homo sapiens	Q86VV4	Validated Y2H	32296183
Intra	TRIP6	Q15654	NSMF	Homo sapiens	Q6X4W1-2	Validated Y2H	32296183
Intra	TRIP6	Q15654	SHISA6	Homo sapiens	Q6ZSJ9	Validated Y2H	32296183
Intra	TRIP6	Q15654	GLIS3	Homo sapiens	Q8NEA6-2	Validated Y2H	32296183
Intra	TRIP6	Q15654	PTPN14	Homo sapiens	Q15678	Validated Y2H	32296183
Intra	TRIP6	Q15654	PRKAA2	Homo sapiens	P54646	Validated Y2H	25416956
Intra	TRIP6	Q15654	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	TRIP6	Q15654	SIK3	Homo sapiens	Q9Y2K2-7	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	SIK3	Homo sapiens	Q9Y2K2-7	Y2H Array	25416956
Intra	TRIP6	Q15654	NEDD9	Homo sapiens	Q14511	Validated Y2H	25416956
Intra	TRIP6	Q15654	TIE1	Homo sapiens	P35590	Validated Y2H	32296183
Intra	TRIP6	Q15654	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	TRIP6	Q15654	MIIP	Homo sapiens	Q5JXC2	Validated Y2H	32296183
Intra	TRIP6	Q15654	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	TRIP6	Q15654	TXNDC5	Homo sapiens	Q86UY0	Validated Y2H	25416956
Intra	TRIP6	Q15654	TXNDC5	Homo sapiens	Q86UY0	Y2H Array	25416956
Intra	TRIP6	Q15654	SMG9	Homo sapiens	Q9H0W8	Validated Y2H	32296183
Intra	TRIP6	Q15654	PIGS	Homo sapiens	Q96S52	Validated Y2H	32296183
Intra	TRIP6	Q15654	TXN2	Homo sapiens	Q99757	Y2H Array	25416956
Intra	TRIP6	Q15654	TXN2	Homo sapiens	Q99757	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	GNAI2	Homo sapiens	P04899	Y2H Array	25416956
Intra	TRIP6	Q15654	GNAI2	Homo sapiens	P04899	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	ATP5PO	Homo sapiens	P48047	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	ATP5PO	Homo sapiens	P48047	Y2H Array	25416956
Intra	TRIP6	Q15654	SLC25A6	Homo sapiens	P12236	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	SLC25A6	Homo sapiens	P12236	Validated Y2H	25416956
Intra	TRIP6	Q15654	SLC25A6	Homo sapiens	P12236	Y2H Array	25416956
Intra	TRIP6	Q15654	GSE1	Homo sapiens	Q14687	Validated Y2H	25416956
Intra	TRIP6	Q15654	GSE1	Homo sapiens	Q14687	Y2H Array	25416956
Intra	TRIP6	Q15654	GSE1	Homo sapiens	Q14687	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	GSE1	Homo sapiens	Q14687	Y2H Array	29892012
Intra	TRIP6	Q15654	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	TRIP6	Q15654	ZNF541	Homo sapiens	Q9H0D2	Validated Y2H	32296183
Cross	TRIP6	Q15654	Hoxa1	Mus musculus	P09022	BiFC	23088713
Intra	TRIP6	Q15654	SAXO1	Homo sapiens	Q8IYX7	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	25416956
Intra	TRIP6	Q15654	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	25416956
Intra	TRIP6	Q15654	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Array	25416956
Intra	TRIP6	Q15654	KCTD9	Homo sapiens	Q7L273	Validated Y2H	32296183
Intra	TRIP6	Q15654	RHOA	Homo sapiens	P61586	Y2H Array	25416956
Intra	TRIP6	Q15654	RHOA	Homo sapiens	P61586	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	OIP5	Homo sapiens	O43482	Y2H Array	31515488
Intra	TRIP6	Q15654	MIEN1	Homo sapiens	Q9BRT3	Validated Y2H	32296183
Intra	TRIP6	Q15654	PDGFRB	Homo sapiens	P09619	Y2H Array	25416956
Intra	TRIP6	Q15654	INCA1	Homo sapiens	Q0VD86	Y2H Array	25416956
Intra	TRIP6	Q15654	C11orf87	Homo sapiens	Q6NUJ2	Validated Y2H	32296183
Intra	TRIP6	Q15654	TRIM29	Homo sapiens	Q14134	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	PPP1R16A	Homo sapiens	Q96I34	Y2H Array	19060904
Intra	TRIP6	Q15654	PPP1R16A	Homo sapiens	Q96I34	Y2H Pooling	19060904
Intra	TRIP6	Q15654	PPP1R16A	Homo sapiens	Q96I34	Y2H Pooling	16189514
Intra	TRIP6	Q15654	NCK2	Homo sapiens	O43639	Y2H Pooling	16189514
Intra	TRIP6	Q15654	NCK2	Homo sapiens	O43639	Y2H Array	31515488
Intra	TRIP6	Q15654	NCK2	Homo sapiens	O43639	Validated Y2H	25416956
Intra	TRIP6	Q15654	NCK2	Homo sapiens	O43639	Y2H Array	25416956
Intra	TRIP6	Q15654	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
Intra	TRIP6	Q15654	FRS3	Homo sapiens	O43559	Validated Y2H	25416956
Intra	TRIP6	Q15654	FRS3	Homo sapiens	O43559	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	TRIP6	Q15654	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	TRIP6	Q15654	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	TRIP6	Q15654	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	RFX3	Homo sapiens	P48380	Validated Y2H	25416956
Intra	TRIP6	Q15654	ABI2	Homo sapiens	Q9NYB9	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	TRIP6	Q15654	ABI2	Homo sapiens	Q9NYB9	Y2H Array	25416956
Intra	TRIP6	Q15654	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	TRIP6	Q15654	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	TRIP6	Q15654	CATSPER1	Homo sapiens	Q8NEC5	Y2H Pooling	16189514
Intra	TRIP6	Q15654	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	TRIP6	Q15654	TRAF3IP2	Homo sapiens	O43734	Validated Y2H	25416956
Intra	TRIP6	Q15654	TRAF3IP2	Homo sapiens	O43734	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	TRIP6	Q15654	AQP1	Homo sapiens	P29972	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	AQP1	Homo sapiens	P29972	Y2H Array	25416956
Intra	TRIP6	Q15654	HOXB9	Homo sapiens	P17482	Validated Y2H	25416956
Intra	TRIP6	Q15654	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
Intra	TRIP6	Q15654	ZNF580	Homo sapiens	Q9UK33	Validated Y2H	32296183
Intra	TRIP6	Q15654	RAD23A	Homo sapiens	P54725	Y2H Array	25416956
Intra	TRIP6	Q15654	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	TRIP6	Q15654	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	TRIP6	Q15654	EXOC3-AS1	Homo sapiens	Q8N2X6	Y2H Pooling	16189514
Intra	TRIP6	Q15654	EXOC3-AS1	Homo sapiens	Q8N2X6	Validated Y2H	25416956
Intra	TRIP6	Q15654	METTL17	Homo sapiens	Q9H7H0	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	METTL17	Homo sapiens	Q9H7H0	Validated Y2H	25416956
Intra	TRIP6	Q15654	METTL17	Homo sapiens	Q9H7H0	Y2H	21516116
Intra	TRIP6	Q15654	METTL17	Homo sapiens	Q9H7H0	Y2H Array	25416956
Intra	TRIP6	Q15654	METTL17	Homo sapiens	Q9H7H0	Y2H Array	29892012
Intra	TRIP6	Q15654	TCAF1	Homo sapiens	Q9Y4C2	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	TCAF1	Homo sapiens	Q9Y4C2	Y2H Array	25416956
Intra	TRIP6	Q15654	TEKT4	Homo sapiens	Q8WW24	Y2H Array	31515488
Intra	TRIP6	Q15654	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	25416956
Intra	TRIP6	Q15654	TEKT4	Homo sapiens	Q8WW24	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	TTLL10	Homo sapiens	Q6ZVT0	Y2H Array	25416956
Intra	TRIP6	Q15654	MSRB3	Homo sapiens	Q8IXL7	Validated Y2H	25416956
Intra	TRIP6	Q15654	KLK15	Homo sapiens	Q9H2R5	Validated Y2H	25416956
Intra	TRIP6	Q15654	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
Intra	TRIP6	Q15654	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	TRIP6	Q15654	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	TRIP6	Q15654	EPDR1	Homo sapiens	Q9UM22	Validated Y2H	32296183
Intra	TRIP6	Q15654	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	25416956
Intra	TRIP6	Q15654	MAPKBP1	Homo sapiens	O60336	Y2H Array	25416956
Intra	TRIP6	Q15654	DMRT3	Homo sapiens	Q9NQL9	Y2H Array	25416956
Intra	TRIP6	Q15654	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	25416956
Cross	TRIP6	Q15654	SVIL	Bos taurus	O46385	Y2H	16880273
Cross	TRIP6	Q15654	SVIL	Bos taurus	O46385	Pull Down	16880273

Cross: Cross-species interaction Intra: Intraspecies interaction

TRIP6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84593	TRIP6 Antibody (YA4290)	WB, FC, ELISA	Human
HY-P84593A	TRIP6 Antibody (YA4290)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15081	TRIP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21797	Trip6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28313	Trip6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIP6	VGNC	VGNC:80699
Mus musculus	TRIP6	MGD	MGI:1343458
Rattus norvegicus	TRIP6	RGD	RGD:1583180
Canis familiaris	TRIP6	VGNC	VGNC:54081
Bos taurus	TRIP6	VGNC	VGNC:107000
Macaca mulatta	TRIP6	VGNC	VGNC:81782
Others	TRIP6	NCBI