SAXO1 - stabilizer of axonemal microtubules 1 Gene

Also Known as FAM154A; C9orf138

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 158297

About SAXO1

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:18,927,650-19,049,339 (from NCBI)

This gene has 5 transcripts (splice variants), 135 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 15.1).

Summary

Enables microtubule binding activity. Involved in several processes, including cold acclimation; positive regulation of cilium assembly; and protein stabilization. Located in microtubule Cytoskeleton and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]

SAXO1 Products (3)

mRNA Protein Name
NM_001287049.2 NP_001273978.1 stabilizer of axonemal microtubules 1 isoform b
NM_001287050.2 NP_001273979.1 stabilizer of axonemal microtubules 1 isoform c
NM_153707.4 NP_714918.2 stabilizer of axonemal microtubules 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
25673876 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23088713 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to cold IDA
IDA: Inferred from direct assay
25673876 GOA
involved in cold acclimation IDA
IDA: Inferred from direct assay
25673876 GOA
involved in positive regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
25673876 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
25673876 GOA
Cellular Component GO Annotation Evidence References Source
located in axonemal microtubule IDA
IDA: Inferred from direct assay
25673876 GOA
located in centriole IDA
IDA: Inferred from direct assay
25673876 GOA
located in ciliary basal body IDA
IDA: Inferred from direct assay
25673876 GOA
located in motile cilium IDA
IDA: Inferred from direct assay
25673876 GOA
located in sperm flagellum IDA
IDA: Inferred from direct assay
25673876 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAXO1 Protein Structure

STOP

STOP: STOP protein (4 - 123)

STOP

STOP: STOP protein (99 - 252)

STOP

STOP: STOP protein (203 - 288)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

stabilizer of axonemal microtubules 1

  • 4930500O09Rik

SAXO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SAXO1 Q8IYX7 IQUB Homo sapiens Q8NA54
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 VPS28 Homo sapiens Q548N1
Y2H Array
25416956
Intra
SAXO1 Q8IYX7 NUDT22 Homo sapiens Q9BRQ3
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 POLR1C Homo sapiens O15160
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 POLR1C Homo sapiens O15160
Y2H Prey Pooling
25416956
Intra
SAXO1 Q8IYX7 TNK1 Homo sapiens Q13470-2
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 TNK1 Homo sapiens Q13470-2
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 CPNE7 Homo sapiens Q9UBL6-2
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 FBXO17 Homo sapiens Q96EF6
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross
SAXO1 Q8IYX7 Hoxa1 Mus musculus P09022
BiFC
23088713
Intra
SAXO1 Q8IYX7 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 HEXIM2 Homo sapiens Q96MH2
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
25416956
Intra
SAXO1 Q8IYX7 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
SAXO1 Q8IYX7 FHL3 Homo sapiens Q13643
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 SORBS3 Homo sapiens O60504
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 SORBS3 Homo sapiens O60504
Y2H Array
25416956
Intra
SAXO1 Q8IYX7 BEGAIN Homo sapiens Q9BUH8
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 BEGAIN Homo sapiens Q9BUH8
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 BEGAIN Homo sapiens Q9BUH8
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
SAXO1 Q8IYX7 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
SAXO1 Q8IYX7 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
SAXO1 Q8IYX7 FAM124A Homo sapiens Q86V42
Y2H Array
25416956
Intra
SAXO1 Q8IYX7 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 ZMYND19 Homo sapiens Q96E35
Y2H Array
25416956
Intra
SAXO1 Q8IYX7 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra
SAXO1 Q8IYX7 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 GLYCTK Homo sapiens Q8IVS8
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 GLYCTK Homo sapiens Q8IVS8
Y2H Prey Pooling
25416956
Intra
SAXO1 Q8IYX7 STK16 Homo sapiens O75716
Y2H Prey Pooling
25416956
Intra
SAXO1 Q8IYX7 STK16 Homo sapiens O75716
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra
SAXO1 Q8IYX7 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
SAXO1 Q8IYX7 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 ACTN2 Homo sapiens P35609
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 ACTN2 Homo sapiens P35609
Y2H Array
31515488
Intra
SAXO1 Q8IYX7 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
25416956
Intra
SAXO1 Q8IYX7 LMO1 Homo sapiens P25800
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 CRK Homo sapiens P46108
Y2H Array
25416956
Intra
SAXO1 Q8IYX7 CRK Homo sapiens P46108
Y2H Prey Pooling
25416956
Intra
SAXO1 Q8IYX7 OSGIN1 Homo sapiens Q9UJX0
Y2H Prey Pooling
25416956
Intra
SAXO1 Q8IYX7 OSGIN1 Homo sapiens Q9UJX0
Validated Y2H
25416956
Intra
SAXO1 Q8IYX7 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra
SAXO1 Q8IYX7 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12461 SAXO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SAXO1 VGNC VGNC:34301
Mus musculus SAXO1 MGD MGI:1923061
Canis familiaris SAXO1 VGNC VGNC:45878
Macaca mulatta SAXO1 VGNC VGNC:77114
Rattus norvegicus SAXO1 RGD RGD:1583685
Felis catus SAXO1 VGNC VGNC:64883
Others SAXO1 NCBI