GLYCTK - glycerate kinase Gene

Homo sapiens

Also known as HBEBP2; HBEBP4; HBeAgBP4A

Gene ID: 132158 | Gene type: protein coding

About GLYCTK

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,287,828-52,295,257 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and is associated with 2 phenotypes. Broad expression in liver (RPKM 19.7), duodenum (RPKM 15.1) and 14 other tissues.

Summary

This locus encodes a member of the glycerate kinase type-2 family. The encoded Enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded Enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

GLYCTK Products(2)

mRNA	Protein	Name
NM_001144951.2	NP_001138423.1	glycerate kinase isoform 2
NM_145262.4	NP_660305.2	glycerate kinase isoform 1

GLYCTK Protein Structure

DUF4147

MOFRL

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

glycerate kinase

HBeAg binding protein 4

Related Diseases

Diseases

Alias

D-Glyceric Aciduria

D-Glyceric Acidemia	D-Glycericacidemia
Glycerate Kinase Deficiency	D-Glycerate Kinase Deficiency
Non Ketotic Hyperglycinemia Syndrome	Deficiency Of Glycerate Kinase
Hyperglycinemia, Non-Ketotic	D-GA

Hyperoxaluria, Primary, Type Ii

Primary Hyperoxaluria Type 2	D-Glycerate Dehydrogenase Deficiency
Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency	HP2
Oxalosis Ii	Glyceric Aciduria
L-Glyceric Aciduria	Primary Hyperoxaluria, Type Ii
Oxalosis 2	Hyperoxaluria Primary 2
Hyperoxaluria Primary Type Ii	Ph2
Primary Hyperoxaluria Type Ii

Ureterolithiasis

Calculus Of Ureter	Ureteric Stone
Ureteral Calculi	Ureteric Calculus
Stone In The Ureter	Ureter Calculi
Ureteral Calculus Or Stone	Ureterolith
Ureterolithiasis Nos

Glycine Encephalopathy

Non-Ketotic Hyperglycinemia	Nonketotic Hyperglycinemia
NKH	GCE
Hyperglycinemia, Nonketotic	Hyperglycinemia Nonketotic
Infantile Glycine Encephalopathy	Encephalopathy, Glycine
Glycine Synthase Deficiency	Nka
Neonatal Glycine Encephalopathy	Classic Glycine Encephalopathy
Neonatal Nkh	Neonatal Non-Ketotic Hyperglycinemia
Infantile Nkh	Infantile Non-Ketotic Hyperglycinemia
Non-Ketotic Hyperglycinaemia	Glycine Cleavage Deficiency
Nonketotic Hyperglycinaemia

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05511	GLYCTK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GLYCTK	VGNC	VGNC:62601
Bos taurus	GLYCTK	VGNC	VGNC:29429
Mus musculus	GLYCTK	MGD	MGI:2444085
Rattus norvegicus	GLYCTK	RGD	RGD:1591498
Canis familiaris	GLYCTK	VGNC	VGNC:97199
Macaca mulatta	GLYCTK	VGNC	VGNC:72993

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