GLYCTK - glycerate kinase Gene

Also Known as HBEBP2; HBEBP4; HBeAgBP4A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 132158

About GLYCTK

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,287,828-52,295,257 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and is associated with 2 phenotypes. Broad expression in liver (RPKM 19.7), duodenum (RPKM 15.1) and 14 other tissues.

Summary

This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

GLYCTK Products (2)

mRNA Protein Name
NM_001144951.2 NP_001138423.1 glycerate kinase isoform 2
NM_145262.4 NP_660305.2 glycerate kinase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycerate kinase activity EXP
EXP: Inferred from Experiment
2537226 GOA
enables glycerate kinase activity IDA
IDA: Inferred from direct assay
16753811 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16753811 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16753811 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLYCTK Protein Structure

DUF4147

DUF4147: Domain of unknown function (DUF4147) (37 - 290)

MOFRL

MOFRL: MOFRL family (401 - 514)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 523 a.a.
Protein Preferred Names Protein Names

glycerate kinase

  • HBeAg binding protein 4

GLYCTK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLYCTK Q8IVS8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 METTL15 Homo sapiens A6NJ78-4
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 METTL15 Homo sapiens A6NJ78-4
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 TUBGCP4 Homo sapiens Q9UGJ1
Y2H Prey Pooling
25416956
Intra
GLYCTK Q8IVS8 TUBGCP4 Homo sapiens Q9UGJ1
Validated Y2H
25416956
Intra
GLYCTK Q8IVS8 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 MIS18A Homo sapiens Q9NYP9
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 MIS18A Homo sapiens Q9NYP9
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 ZFP90 Homo sapiens Q8TF47
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ZFP90 Homo sapiens Q8TF47
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ZFP90 Homo sapiens Q8TF47
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ZIM2 Homo sapiens Q9NZV7
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 ZIM2 Homo sapiens Q9NZV7
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 POMC Homo sapiens P01189
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 POMC Homo sapiens P01189
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 KRT13 Homo sapiens P13646
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 KRT13 Homo sapiens P13646
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 SMUG1 Homo sapiens Q53HV7-2
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 SMUG1 Homo sapiens Q53HV7-2
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PUDP Homo sapiens Q08623
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PUDP Homo sapiens Q08623
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 ATP23 Homo sapiens Q9Y6H3
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ANKRD53 Homo sapiens Q8N9V6-2
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ANKRD53 Homo sapiens Q8N9V6-2
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ANKRD53 Homo sapiens Q8N9V6-2
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 NOTO Homo sapiens A8MTQ0
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 NOTO Homo sapiens A8MTQ0
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 RBCK1 Homo sapiens Q9BYM8
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 RBCK1 Homo sapiens Q9BYM8
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 RBCK1 Homo sapiens Q9BYM8
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Pooling
19060904
Intra
GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
Intra
GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Array
19060904
Intra
GLYCTK Q8IVS8 TRIP13 Homo sapiens Q15645
Y2H Array
25416956
Intra
GLYCTK Q8IVS8 SAXO1 Homo sapiens Q8IYX7
Y2H Array
25416956
Intra
GLYCTK Q8IVS8 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ZNF688 Homo sapiens P0C7X2
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ZNF688 Homo sapiens P0C7X2
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 SPRED1 Homo sapiens Q7Z699
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 SPRED1 Homo sapiens Q7Z699
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra
GLYCTK Q8IVS8 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
25416956
Intra
GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
GLYCTK Q8IVS8 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ARMC5 Homo sapiens Q96C12
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 ARMC5 Homo sapiens Q96C12
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 ARMC5 Homo sapiens Q96C12
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
GLYCTK Q8IVS8 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra
GLYCTK Q8IVS8 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra
GLYCTK Q8IVS8 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra
GLYCTK Q8IVS8 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra
GLYCTK Q8IVS8 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 NT5C2 Homo sapiens P49902
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 NT5C2 Homo sapiens P49902
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ZG16 Homo sapiens O60844
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 ZG16 Homo sapiens O60844
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 SNF8 Homo sapiens Q96H20
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 SNF8 Homo sapiens Q96H20
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 SNF8 Homo sapiens Q96H20
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 SERTAD1 Homo sapiens Q9UHV2
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 GMPPB Homo sapiens Q9Y5P6
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 GMPPB Homo sapiens Q9Y5P6
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 GMPPB Homo sapiens Q9Y5P6
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 IHO1 Homo sapiens Q8IYA8
Validated Y2H
32296183
Intra
GLYCTK Q8IVS8 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra
GLYCTK Q8IVS8 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra
GLYCTK Q8IVS8 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
D-Glyceric Aciduria

  • D-Glyceric Acidemia

  • D-Glycericacidemia

  • Glycerate Kinase Deficiency

  • D-Glycerate Kinase Deficiency

  • Non Ketotic Hyperglycinemia Syndrome

  • Deficiency Of Glycerate Kinase

  • Hyperglycinemia, Non-Ketotic

  • D-GA
Hyperoxaluria, Primary, Type Ii

  • Primary Hyperoxaluria Type 2

  • D-Glycerate Dehydrogenase Deficiency

  • Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency

  • HP2

  • Oxalosis Ii

  • Glyceric Aciduria

  • L-Glyceric Aciduria

  • Primary Hyperoxaluria, Type Ii

  • Oxalosis 2

  • Hyperoxaluria Primary 2

  • Hyperoxaluria Primary Type Ii

  • Ph2

  • Primary Hyperoxaluria Type Ii
Ureterolithiasis

  • Calculus Of Ureter

  • Ureteric Stone

  • Ureteral Calculi

  • Ureteric Calculus

  • Stone In The Ureter

  • Ureter Calculi

  • Ureteral Calculus Or Stone

  • Ureterolith

  • Ureterolithiasis Nos
Glycine Encephalopathy

  • Non-Ketotic Hyperglycinemia

  • Nonketotic Hyperglycinemia

  • NKH

  • GCE

  • Hyperglycinemia, Nonketotic

  • Hyperglycinemia Nonketotic

  • Infantile Glycine Encephalopathy

  • Encephalopathy, Glycine

  • Glycine Synthase Deficiency

  • Nka

  • Neonatal Glycine Encephalopathy

  • Classic Glycine Encephalopathy

  • Neonatal Nkh

  • Neonatal Non-Ketotic Hyperglycinemia

  • Infantile Nkh

  • Infantile Non-Ketotic Hyperglycinemia

  • Non-Ketotic Hyperglycinaemia

  • Glycine Cleavage Deficiency

  • Nonketotic Hyperglycinaemia
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05511 GLYCTK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21859 Glyctk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28376 Glyctk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GLYCTK VGNC VGNC:62601
Bos taurus GLYCTK VGNC VGNC:29429
Mus musculus GLYCTK MGD MGI:2444085
Rattus norvegicus GLYCTK RGD RGD:1591498
Canis familiaris GLYCTK VGNC VGNC:97199
Macaca mulatta GLYCTK VGNC VGNC:72993
Others GLYCTK NCBI