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UFSP1 - UFM1 specific peptidase 1 (inactive) Gene

Also Known as UFSP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 402682

About UFSP1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,888,721-100,889,715 (from NCBI)

This gene has 2 transcripts (splice variants), 148 orthologues and 1 paralogue.

Summary

This gene encodes a protein that is similar to Other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009]

UFSP1 Products (1)

mRNA	Protein	Name
NM_001015072.4	NP_001015072.2	inactive Ufm1-specific protease 1

UFSP1 Protein Structure

Peptidase_C78

0
100
142 a.a.

Protein Preferred Names	Protein Names
inactive Ufm1-specific protease 1	UFM1-specific peptidase 1 (non-functional)

UFSP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UFSP1	Q6NVU6	MSRB3	Homo sapiens	Q8IXL7-2	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	TCF7L2	Homo sapiens	Q9NQB0-10	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	VAX2	Homo sapiens	Q9UIW0	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	PITX2	Homo sapiens	Q99697-2	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	CIDEC	Homo sapiens	Q96AQ7	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	UFSP1	Q6NVU6	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	UFSP1	Q6NVU6	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	SMARCC1	Homo sapiens	Q92922	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	UFSP1	Q6NVU6	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	UFSP1	Q6NVU6	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	UFSP1	Q6NVU6	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	UFSP1	Q6NVU6	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	UFSP1	Q6NVU6	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	UFSP1	Q6NVU6	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	GLYCTK	Homo sapiens	Q8IVS8	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	UFSP1	Q6NVU6	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	UFSP1	Q6NVU6	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Beukes Hip Dysplasia	Hip Dysplasia, Beukes Type Beukes Familial Hip Dysplasia BFHD Cilliers-Beighton Syndrome Osteoarthropathy, Premature Degenerative, Of Hip Premature Degenerative Osteoarthropathy Of The Hip BHD Beukes Type Hip Dysplasia Hip Dysplasia Beukes Type Premature Degenerative Osteoarthropathy Dysplasia, Hip, Beukes Type
Spinocerebellar Ataxia, Autosomal Recessive 24	SCAR24 Autosomal Recessive Spinocerebellar Ataxia 24 Spinocerebellar Ataxia, Autosomal Recessive, 24 Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15417	UFSP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UFSP1	VGNC	VGNC:107826
Mus musculus	UFSP1	MGD	MGI:1917490
Rattus norvegicus	UFSP1	RGD	RGD:7536909
Macaca mulatta	UFSP1	VGNC	VGNC:81787
Others	UFSP1	NCBI