UBQLN2 - ubiquilin 2 Gene

Also Known as DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29978

About UBQLN2

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:56,563,627-56,567,868 (from NCBI)

This gene has 1 transcript (splice variant), 86 orthologues, 5 paralogues and is associated with 2 phenotypes.

Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the Proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]

UBQLN2 Products (1)

mRNA	Protein	Name
NM_013444.4	NP_038472.2	ubiquilin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	29526694	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231748	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	24215460	GOA
involved in negative regulation of G protein-coupled receptor internalization	IMP IMP: Inferred from mutant phenotype	18199683	GOA
involved in negative regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	18199683	GOA
involved in positive regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	18307982	GOA
involved in regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	20529957	GOA
involved in regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	20529957	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18199683	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBQLN2 Protein Structure

ubiquitin

UBA

0
100
200
300
400
500
624 a.a.

Protein Preferred Names	Protein Names
ubiquilin-2	Nedd4 binding protein 4

UBQLN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBQLN2	Q9UHD9	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	KRTAP12-1	Homo sapiens	P59990	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	KRTAP12-1	Homo sapiens	P59990	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	DEFA6	Homo sapiens	Q01524	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	DEFA6	Homo sapiens	Q01524	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	HEMK1	Homo sapiens	Q9Y5R4	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	TIMP2	Homo sapiens	P16035	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	TIMP2	Homo sapiens	P16035	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	CST4	Homo sapiens	P01036	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	PNMA3	Homo sapiens	Q9UL41	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	IFNA13	Homo sapiens	P01562	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	IFNA13	Homo sapiens	P01562	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	WFDC12	Homo sapiens	Q8WWY7	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	WFDC12	Homo sapiens	Q8WWY7	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	RBFOX2	Homo sapiens	O43251-10	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	RBFOX2	Homo sapiens	O43251-10	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	PSORS1C2	Homo sapiens	Q9UIG4	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	C6orf15	Homo sapiens	Q6UXA7	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	C6orf15	Homo sapiens	Q6UXA7	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	CLPSL2	Homo sapiens	Q6UWE3	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	CLPSL2	Homo sapiens	Q6UWE3	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	TNFRSF18	Homo sapiens	Q9Y5U5-2	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	PCDHGA9	Homo sapiens	Q9Y5G4-2	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	GALP	Homo sapiens	Q9UBC7	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	GALP	Homo sapiens	Q9UBC7	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	SFTPA2	Homo sapiens	Q8IWL1	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	SFTPA2	Homo sapiens	Q8IWL1	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	LY6G6D	Homo sapiens	O95868	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	LY6G6D	Homo sapiens	O95868	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	NPBWR1	Homo sapiens	P48145	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	NPBWR1	Homo sapiens	P48145	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	NRN1L	Homo sapiens	Q496H8	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	NRN1L	Homo sapiens	Q496H8	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	PMEPA1	Homo sapiens	Q969W9-2	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	PMEPA1	Homo sapiens	Q969W9-2	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	CSN2	Homo sapiens	P05814	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	CSN2	Homo sapiens	P05814	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	ANKRD33	Homo sapiens	Q7Z3H0-1	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	ANKRD33	Homo sapiens	Q7Z3H0-1	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	SMIM19	Homo sapiens	Q96E16	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	SMIM19	Homo sapiens	Q96E16	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	LATS1	Homo sapiens	O95835-2	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	LATS1	Homo sapiens	O95835-2	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	OPN4	Homo sapiens	Q9UHM6	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	OPN4	Homo sapiens	Q9UHM6	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	OPN4	Homo sapiens	Q9UHM6	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	APOC4	Homo sapiens	P55056	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	APOC4	Homo sapiens	P55056	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	PRAP1	Homo sapiens	Q96NZ9	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	PRAP1	Homo sapiens	Q96NZ9	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	KISS1	Homo sapiens	Q15726	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	KISS1	Homo sapiens	Q15726	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	COL17A1	Homo sapiens	Q9UMD9	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	COL17A1	Homo sapiens	Q9UMD9	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	COL17A1	Homo sapiens	Q9UMD9	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	JPH4	Homo sapiens	Q96JJ6	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	JPH4	Homo sapiens	Q96JJ6	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	HNRNPU	Homo sapiens	Q00839	Pull Down	25616961
Intra	UBQLN2	Q9UHD9	HNRNPU	Homo sapiens	Q00839	Y2H	25616961
Intra	UBQLN2	Q9UHD9	HNRNPA1	Homo sapiens	P09651	Pull Down	25616961
Intra	UBQLN2	Q9UHD9	HNRNPA1	Homo sapiens	P09651	Anti Tag CoIP	25616961
Intra	UBQLN2	Q9UHD9	HNRNPA1	Homo sapiens	P09651-2	Y2H	25616961
Intra	UBQLN2	Q9UHD9	HNRNPA1	Homo sapiens	P09651-2	Anti Tag CoIP	25616961
Intra	UBQLN2	Q9UHD9	PSMD2	Homo sapiens	Q13200	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	PSMD2	Homo sapiens	Q13200	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	NPY	Homo sapiens	P01303	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	NPY	Homo sapiens	P01303	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	AGR3	Homo sapiens	Q8TD06	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	AGR3	Homo sapiens	Q8TD06	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	CLEC11A	Homo sapiens	Q9Y240	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	MINPP1	Homo sapiens	Q9UNW1	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	BCL2L11	Homo sapiens	O43521	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	BCL2L11	Homo sapiens	O43521	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	MBL2	Homo sapiens	P11226	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	MBL2	Homo sapiens	P11226	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	UBQLN2	Q9UHD9	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	UBQLN2	Q9UHD9	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	UBQLN2	Q9UHD9	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	MDK	Homo sapiens	P21741	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	MDK	Homo sapiens	P21741	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	PRR4	Homo sapiens	Q16378	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	PRR4	Homo sapiens	Q16378	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	NOL3	Homo sapiens	O60936	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	NOL3	Homo sapiens	O60936	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	UBQLN2	Q9UHD9	RAD23A	Homo sapiens	P54725	Anti Bait CoIP	17098253
Intra	UBQLN2	Q9UHD9	GPX7	Homo sapiens	Q96SL4	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	GPX7	Homo sapiens	Q96SL4	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	ASPA	Homo sapiens	P45381	Validated Y2H	32814053
Intra	UBQLN2	Q9UHD9	ASPA	Homo sapiens	P45381	Y2H Array	32814053
Intra	UBQLN2	Q9UHD9	ASPA	Homo sapiens	P45381	Y2H Pooling	32814053
Intra	UBQLN2	Q9UHD9	ITPKB	Homo sapiens	P27987	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	RNF208	Homo sapiens	Q9H0X6	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	RNF208	Homo sapiens	Q9H0X6	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	ADRM1	Homo sapiens	Q16186	Pull Down	20059542
Intra	UBQLN2	Q9UHD9	ECM1	Homo sapiens	Q16610	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	ECM1	Homo sapiens	Q16610	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	PTGDS	Homo sapiens	P41222	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	PTGDS	Homo sapiens	P41222	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	ERP27	Homo sapiens	Q96DN0	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	ERP27	Homo sapiens	Q96DN0	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	ZG16B	Homo sapiens	Q96DA0	Y2H Array	32296183
Intra	UBQLN2	Q9UHD9	ZG16B	Homo sapiens	Q96DA0	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	ASCL1	Homo sapiens	P50553	Y2H Prey Pooling	32296183
Intra	UBQLN2	Q9UHD9	ASCL1	Homo sapiens	P50553	Y2H Array	32296183
Cross	UBQLN2	Q9UHD9	RPN13	Arabidopsis thaliana	O48726	Pull Down	20059542

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia	Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia ALS15 Sclerosis, Lateral, Amyotrophic, Type 15, With/Without Frontotemporal Dementia
Amyotrophic Lateral Sclerosis Type 15	Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia Als15 Amyotrophic Lateral Sclerosis 15
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Lateral Sclerosis	Primary Lateral Sclerosis Adult-Onset Primary Lateral Sclerosis Adult-Onset Pls Motor Neuron Disease Pls Pls - [Primary Lateral Sclerosis] Lateral Spinal Sclerosis Lateral Complete Paralysis Lateral Incomplete Paralysis Lateral Paralysis
Amyotrophic Lateral Sclerosis 18	Amyotrophic Lateral Sclerosis Type 18 ALS18 Sclerosis, Lateral, Amyotrophic, Type 18
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Amyotrophic Lateral Sclerosis 16, Juvenile	Amyotrophic Lateral Sclerosis Type 16 ALS16 Amyotrophic Lateral Sclerosis 16 Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile
Amyotrophic Lateral Sclerosis 19	Amyotrophic Lateral Sclerosis Type 19 ALS19 Sclerosis, Lateral, Amyotrophic, Type 19
Amyotrophic Lateral Sclerosis Type 14	Als14 Amyotrophic Lateral Sclerosis 14 Amyotrophic Lateral Sclerosis, With Or Without Frontotemporal Dementia Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia
Spinocerebellar Ataxia 2	Spinocerebellar Ataxia Type 2 SCA2 Amyotrophic Lateral Sclerosis 13 Spinocerebellar Degeneration With Slow Eye Movements SDSEM Spinocerebellar Atrophy Ii Olivopontocerebellar Atrophy Ii Opca2 Cerebellar Degeneration With Slow Eye Movements Wadia-Swami Syndrome Amyotrophic Lateral Sclerosis Type 13 ALS13 Olivopontocerebellar Atrophy Holguin Type Spinocerebellar Ataxia Cuban Type Olivopontocerebellar Atrophy, Holguin Type Spinocerebellar Ataxia, Cuban Type Amyotrophic Lateral Sclerosis, Susceptibility To, 13 Olivopontocerebellar Atrophy 2 Sca 2 Spinocerebellar Ataxia With Slow Eye Movements Spinocerebellar Atrophy 2 Wadia Swami Syndrome Opca Ii Spinocerebellar Ataxia-2 Ataxia, Spinocerebellar, Type 2
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 20	Amyotrophic Lateral Sclerosis Type 20 ALS20 Sclerosis, Lateral, Amyotrophic, Type 20
Multisystem Proteinopathy
Amyotrophic Lateral Sclerosis Type 22	Als 22 Amyotrohpic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia Amyotrophic Lateral Sclerosis 22
Brown-Vialetto-Van Laere Syndrome
Progressive Muscular Atrophy	Progressive Spinal Muscular Atrophy Pure Progressive Muscular Atrophy Pma Hereditary Spinal Muscle Atrophy Pma - [Progressive Muscular Atrophy] Progressive Muscle Atrophy Progressive Spinal Muscle Atrophy Duchenne-Aran Atrophy Duchenne-Aran Muscle Atrophy Hereditary Sma - [Spinal Muscle Atrophy]
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Amyotrophic Lateral Sclerosis Type 12	Amyotrophic Lateral Sclerosis 12 Als12 Sclerosis, Lateral, Amyotrophic, Type Type 12
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Amyotrophic Lateral Sclerosis Type 6	Amyotrophic Lateral Sclerosis 6, Autosomal Recessive Als6 Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia Autosomal Recessive Amyotrophic Lateral Sclerosis 6 Sclerosis, Lateral, Amyotrophic, Type Type 6 Amyotrophic Lateral Sclerosis 6
Progressive Bulbar Palsy	Bulbar Palsy, Progressive Progressive Bulbar Atrophy Bulbar Palsy Pbp - [Progressive Bulbar Palsy] Progressive Bulbar Paralysis Bulbar Paralysis Chronic Bulbar Palsy Chronic Bulbar Paralysis Supranuclear Bulbar Paralysis
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia	Amyotrophic Lateral Sclerosis Type 10 ALS10 Amyotrophic Lateral Sclerosis 10, With Or Without Ftd Frontotemporal Lobar Degeneration, Tardbp-Related Amyotrophic Lateral Sclerosis 10 Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia Tardbp-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia And With Tdp43 Inclusions Sclerosis, Lateral, Amyotrophic, Type Type 10
Giant Axonal Neuropathy 2
Perry Syndrome	Parkinsonism With Alveolar Hypoventilation And Mental Depression PERRYS
Amyotrophic Lateral Sclerosis 8	Amyotrophic Lateral Sclerosis Type 8 ALS8 Sclerosis, Lateral, Amyotrophic, Type Type 8
Amyotrophic Lateral Sclerosis 4, Juvenile	Amyotrophic Lateral Sclerosis Type 4 ALS4 Amyotrophic Lateral Sclerosis 4 Dhmn With Upper Motor Neuron Signs Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs Neuronopathy, Distal Hereditary Motor, With Pyramidal Features Als 4 Distal Hereditary Motor Neuropathy With Pyramidal Features Amyotrophic Lateral Sclerosis Juvenile 4 Neuronopathy Distal Hereditary Motor With Pyramidal Features Sclerosis, Lateral, Amyotrophic, Type Type 4
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15384	UBQLN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UBQLN2	VGNC	VGNC:66782
Rattus norvegicus	UBQLN2	RGD	RGD:1563566
Mus musculus	UBQLN2	MGD	MGI:1860283
Bos taurus	UBQLN2	VGNC	VGNC:36614
Canis familiaris	UBQLN2	VGNC	VGNC:48085
Others	UBQLN2	NCBI