PRR4 - proline rich 4 Gene

Also Known as LPRP; PROL4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11272

About PRR4

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,845,849-10,849,475 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 14 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 1815.0).

Summary

This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]

PRR4 Products (2)

mRNA	Protein	Name
NM_001098538.3	NP_001092008.2	proline-rich protein 4 isoform 1 precursor
NM_007244.3	NP_009175.2	proline-rich protein 4 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR4 Protein Structure

Pro-rich

0
100
134 a.a.

Protein Preferred Names	Protein Names
proline-rich protein 4	lacrimal proline-rich protein

PRR4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRR4	Q16378	MIEF1	Homo sapiens	Q9NQG6	Validated Y2H	32296183
Intra	PRR4	Q16378	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	PRR4	Q16378	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	PRR4	Q16378	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PRR4	Q16378	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PRR4	Q16378	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ectodermal Dysplasia-Syndactyly Syndrome 1	EDSS1 Ectodermal Dysplasia-Syndactyly Syndrome Edss Dysplasia, Ectodermal, Syndactyly Syndrome, Type 1
Epicondylitis	Tennis Elbow Lateral Epicondylitis Golfer'S Elbow Medial Epicondylitis Andrel Epicondylitis Archer'S Elbow Hockey Elbow Shooter'S Elbow
Rubeosis Iridis
Perforated Corneal Ulcer
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Chronic Follicular Conjunctivitis
Shoulder Impingement Syndrome	Impingement Syndrome Of Shoulder Region Subacromial Impingement
Peroneal Nerve Paralysis	Peroneal Nerve Palsy
Papillary Conjunctivitis
Gingival Recession	Localized Gingival Recession Gingival Recession, Localized Minimal Gingival Recession Moderate Gingival Recession Severe Gingival Recession Gingival Recession, Minimal Gingival Recession, Severe Atrophy Of Gums Gum Atrophy Gingival Atrophy
Lacrimal Apparatus Disease	Lacrimal Apparatus Diseases
Giant Papillary Conjunctivitis	Gpc Conjunctivitis Giant Papillary Conjunctivitis, Giant Papillary Chronic Giant Papillary Conjunctivitis Chronic Papillary Conjunctivitis
Dry Eye Syndrome	Dry Eye Syndromes Dry Eye Disease Tear Film Insufficiency Xerophthalmia
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
External Ear Disease	Diseases Of External Ear Preauricular Cyst Preauricular Sinus And Fistula Preauricular Sinus Or Fistula
Otitis Externa	Swimmer'S Ear Infective Otitis Externa Acute Infective Otitis Externa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09177	NECTIN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11231	PRR4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21247	Nectin4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24216	Prr4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRR4	RGD	RGD:735181
Others	PRR4	NCBI