HEMK1 - HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine Gene

Also Known as HEMK; MTQ1; MPRMC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51409

Summary

Enables peptide chain release factor N(5)-glutamine methyltransferase activity. Predicted to be involved in translational termination. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in thyroid (RPKM 4.4), ovary (RPKM 4.1) and 25 other tissues.

HEMK1 Products (12)

mRNA Protein Name
NM_001317851.2 NP_001304780.1 MTRF1L release factor glutamine methyltransferase isoform 1
NM_001377420.1 NP_001364349.1 MTRF1L release factor glutamine methyltransferase isoform 1
NM_001377421.1 NP_001364350.1 MTRF1L release factor glutamine methyltransferase isoform 1
NM_001377422.1 NP_001364351.1 MTRF1L release factor glutamine methyltransferase isoform 1
NM_001377423.1 NP_001364352.1 MTRF1L release factor glutamine methyltransferase isoform 2
NM_001377424.1 NP_001364353.1 MTRF1L release factor glutamine methyltransferase isoform 3
NM_001377425.1 NP_001364354.1 MTRF1L release factor glutamine methyltransferase isoform 4
NM_001377426.1 NP_001364355.1 MTRF1L release factor glutamine methyltransferase isoform 4
NM_001377427.1 NP_001364356.1 MTRF1L release factor glutamine methyltransferase isoform 4
NM_001377428.1 NP_001364357.1 MTRF1L release factor glutamine methyltransferase isoform 4
NM_001377429.1 NP_001364358.1 MTRF1L release factor glutamine methyltransferase isoform 4
NM_016173.5 NP_057257.1 MTRF1L release factor glutamine methyltransferase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein-(glutamine-N5) methyltransferase activity IDA
IDA: Inferred from direct assay
35260756 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HEMK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HEMK1 Q9Y5R4 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 ASCL3 Homo sapiens Q9NQ33
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 ASCL3 Homo sapiens Q9NQ33
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 SOHLH1 Homo sapiens Q5JUK2
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 SOHLH1 Homo sapiens Q5JUK2
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 SPRYD7 Homo sapiens Q5W111-2
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 SPRYD7 Homo sapiens Q5W111-2
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 SHOX Homo sapiens O15266-2
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 SHOX Homo sapiens O15266-2
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 HEATR9 Homo sapiens A2RTY3
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 HEATR9 Homo sapiens A2RTY3
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 TUBGCP5 Homo sapiens Q96RT8
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 TUBGCP5 Homo sapiens Q96RT8
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 CDC23 Homo sapiens Q9UJX2
Validated Y2H
25416956
Intra
HEMK1 Q9Y5R4 CDC23 Homo sapiens Q9UJX2
Y2H Prey Pooling
25416956
Intra
HEMK1 Q9Y5R4 CDC23 Homo sapiens Q9UJX2
Y2H Array
25416956
Intra
HEMK1 Q9Y5R4 PSMB4 Homo sapiens P28070
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 PSMB4 Homo sapiens P28070
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
HEMK1 Q9Y5R4 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 CHN1 Homo sapiens P15882
Y2H Array
25416956
Intra
HEMK1 Q9Y5R4 CHN1 Homo sapiens P15882
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 CHN1 Homo sapiens P15882
Y2H Array
31515488
Intra
HEMK1 Q9Y5R4 CHN1 Homo sapiens P15882
Validated Y2H
25416956
Intra
HEMK1 Q9Y5R4 CHN1 Homo sapiens P15882
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 PEF1 Homo sapiens Q9UBV8
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 PEF1 Homo sapiens Q9UBV8
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 POU2AF1 Homo sapiens Q16633
Y2H Array
32296183
Intra
HEMK1 Q9Y5R4 POU2AF1 Homo sapiens Q16633
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
HEMK1 Q9Y5R4 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16468 HEMK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22550 Hemk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29070 Hemk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown