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POU2AF1 - POU class 2 homeobox associating factor 1 Gene

Also Known as BOB1; OBF1; OCAB; OBF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5450

About POU2AF1

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,352,255-111,379,275 (from NCBI)

This gene has 12 transcripts (splice variants), 118 orthologues and is associated with 57 phenotypes. Biased expression in lymph node (RPKM 29.3), appendix (RPKM 16.6) and 9 other tissues.

Summary

Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

POU2AF1 Products (1)

mRNA	Protein	Name
NM_006235.3	NP_006226.2	POU domain class 2-associating factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11483518	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	11380252	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11380252	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	11380252	GOA
part of RNA polymerase II transcription regulator complex	IMP IMP: Inferred from mutant phenotype	10329190	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU2AF1 Protein Structure

PD-C2-AF1

0
100
200
256 a.a.

Protein Preferred Names	Protein Names
POU domain class 2-associating factor 1	B-cell-specific coactivator OBF-1

POU2AF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POU2AF1	Q16633	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	POU2AF1	Q16633	HEMK1	Homo sapiens	Q9Y5R4	Validated Y2H	32296183
Intra	POU2AF1	Q16633	ATE1	Homo sapiens	O95260	Anti Tag CoIP	33961781
Intra	POU2AF1	Q16633	ATE1	Homo sapiens	O95260	Anti Tag CoIP	28514442
Intra	POU2AF1	Q16633	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	POU2AF1	Q16633	KRTAP13-2	Homo sapiens	Q52LG2	Validated Y2H	32296183
Intra	POU2AF1	Q16633	KRTAP15-1	Homo sapiens	Q3LI76	Validated Y2H	32296183
Intra	POU2AF1	Q16633	KRTAP19-3	Homo sapiens	Q7Z4W3	Validated Y2H	32296183
Intra	POU2AF1	Q16633	PITX2	Homo sapiens	Q99697-2	Validated Y2H	32296183
Intra	POU2AF1	Q16633	RBM24	Homo sapiens	Q9BX46-2	Validated Y2H	32296183
Intra	POU2AF1	Q16633	NDUFAF3	Homo sapiens	Q9BU61	Validated Y2H	32296183
Intra	POU2AF1	Q16633	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	POU2AF1	Q16633	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	32296183
Intra	POU2AF1	Q16633	HGS	Homo sapiens	O14964	Y2H Prey Pooling	32296183
Intra	POU2AF1	Q16633	DGCR6L	Homo sapiens	Q9BY27	Validated Y2H	32296183
Intra	POU2AF1	Q16633	RAMAC	Homo sapiens	Q9BTL3	Validated Y2H	32296183
Intra	POU2AF1	Q16633	ZNF414	Homo sapiens	Q96IQ9	Validated Y2H	32296183
Intra	POU2AF1	Q16633	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	POU2AF1	Q16633	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
Intra	POU2AF1	Q16633	SIAH1	Homo sapiens	Q8IUQ4	Y2H	11483518
Intra	POU2AF1	Q16633	SIAH1	Homo sapiens	Q8IUQ4	Pull Down	11483518
Intra	POU2AF1	Q16633	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

POU2AF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82467	BOB1 Antibody (YA2212)	WB, IHC-P, ICC/IF, FC	Human
HY-P85829	BOB1 Antibody (YA5521)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
HY-P85980	BOB1 Antibody (YA5672)	IHC-P, ELISA	Human, Mouse,

Related Diseases

Diseases	Alias
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Mediastinal Gray Zone Lymphoma	Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma	Lymphoma Of Mediastinum Mediastinal Lymphoma
Gray Zone Lymphoma	B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Hodgkin'S Lymphoma, Lymphocytic Depletion	Hodgkin Lymphoma, Lymphocyte Depletion Hodgkin'S Disease, Lymphocytic Depletion Hodgkin'S Lymphocytic Depletion Of Unspecified Site Lymphocyte-Depleted Classical Hodgkin Lymphoma Classic Hodgkin Lymphoma, Lymphocyte-Depleted Type Hodgkin Disease, Lymphocytic Depletion Hodgkin Lymphocytic Depletion
Methotrexate-Associated Lymphoproliferation
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Hodgkin'S Lymphoma, Nodular Sclerosis	Classical Hodgkin Lymphoma, Nodular Sclerosis Classic Hodgkin Lymphoma, Nodular Sclerosis Type Nodular Sclerosis Hodgkin Lymphoma Hodgkin'S Disease, Nodular Sclerosis Hodgkin Disease, Nodular Sclerosis Hodgkin Lymphoma, Nodular Sclerosis Hodgkin Nodular Sclerosis
Appendix Lymphoma	Appendiceal Lymphoma
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10896	POU2AF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	POU2AF1	VGNC	VGNC:76222
Felis catus	POU2AF1	VGNC	VGNC:81957
Mus musculus	POU2AF1	MGD	MGI:105086
Canis familiaris	POU2AF1	VGNC	VGNC:44825
Rattus norvegicus	POU2AF1	RGD	RGD:1594728
Bos taurus	POU2AF1	VGNC	VGNC:33173
Others	POU2AF1	NCBI