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Cat. No.: HY-P85980

BOB1 Antibody (YA5672)

Name: BOB1 Antibody (YA5672)
Brand: MedChemExpress
SKU: HY-P85980
Availability: PreOrder

BOB1 Antibody (YA5672) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BOB1.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:50-200	1:500-5000

Description

BOB1 Antibody (YA5672) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BOB1.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human, Mouse,
Observed Molecular Weight

Observed band size: 35 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 27 kDa

Immunogen

Synthesized peptide derived from human BOB.1 AA range: 150-256

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG2a

Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

BOB1 transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator^[1]^[2]^[3].
Subcellular Localization

Nucleus
Expression

Tissue_specificity:B cell specific (PubMed:7779176, PubMed:7859290) . It is mainly detected in the spleen, but is also found in the thymus, peripheral blood leukocytes, and small intestine (PubMed:7779176, PubMed:7859290) .
Subunit

Interacts with POU2F1/OCT1 and POU2F2/OCT2; the interaction increases POU2F1 and POU2F2 transactivation activity
SwissProt ID

Q16633
Gene ID

5450 [NCBI]