TFG - trafficking from ER to golgi regulator Gene

Homo sapiens

Also known as TF6; HMSNP; SPG57; TRKT3

Gene ID: 10342 | Gene type: protein coding

About TFG

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,709,290-100,748,967 (from NCBI)

This gene has 36 transcripts (splice variants), 217 orthologues and is associated with 67 phenotypes. Ubiquitous expression in duodenum (RPKM 35.2), placenta (RPKM 33.3) and 25 other tissues.

Summary

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

TFG Products(4)

mRNA	Protein	Name
NM_001007565.2	NP_001007566.1	protein TFG isoform 1
NM_001195478.2	NP_001182407.1	protein TFG isoform 1
NM_001195479.2	NP_001182408.1	protein TFG isoform 2
NM_006070.6	NP_006061.2	protein TFG isoform 1

TFG Protein Structure

PB1

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

protein TFG

TRK-fused

Related Diseases

Diseases

Alias

Spastic Paraplegia 57, Autosomal Recessive

SPG57	Hereditary Spastic Paraplegia 57
Autosomal Recessive Spastic Paraplegia Type 57	Autosomal Recessive Spastic Paraplegia 57
Spastic Paraplegia Due To Partial Tfg Deficiency	Paraplegia, Spastic, Type 57, Autosomal Recessive

Neuropathy, Hereditary Motor And Sensory, Okinawa Type

Hereditary Motor And Sensory Neuropathy, Okinawa Type	HMSNO
Hereditary Motor And Sensory Neuropathy, Proximal Type	Hmsnp
Hereditary Motor And Sensory Neuropathy, Proximal Type, Formerly	Hmsnp, Formerly
Hereditary Motor And Sensory Neuropathy Okinawa	Neuropathy, Motor And Sensory, Hereditary, Okinawa Type

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Tfg Mutation

Cmt2 Due To Tfg Mutation

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Anaplastic Large Cell Lymphoma

Alcl	Cd30 Positive Anaplastic Large Cell Lymphoma
Ki-1 Positive Anaplastic Large Cell Lymphoma	Primary Systemic Alcl
Sacl	Ki-1+ Anaplastic Large Cell Lymphoma

Chondrosarcoma

Cartilaginous Cancer	Chondrosarcoma Of Bone
Primary Chondrosarcoma Of The Bone	CHDSA

Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe	Malignant Neoplasm Of Occipital Lobe
Tumor Of Occipital Lobe

Paraplegia

Paraplegia, Lower

Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Dental Fluorosis

Mottled Teeth	Intrinsic Enamel Discolouration Of Fluorosis
Mottling Of Enamel	Fluorosis, Dental
Dental Fluorosis, Acquired

Bone Chondrosarcoma

Spondylometaphyseal Dysplasia, Corner Fracture Type

SMDCF	Spondylometaphyseal Dysplasia, Sutcliffe Type
Spondylometaphyseal Dysplasia Corner Fracture Type	Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Spondylometaphyseal Dysplasia Sutcliffe Type	Sutcliffe Type Of Spondylometaphyseal Dysplasia
Spondylometaphyseal Dysplasia - Sutcliffe Type	Smd, Corner Fractures Type
Smd, Sutcliffe Type	Sutcliffe Smd
Dysplasia, Spondylometaphyseal, Corner Fracture Type

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14425	TFG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TFG	RGD	RGD:1309751
Macaca mulatta	TFG	VGNC	VGNC:82715
Canis familiaris	TFG	VGNC	VGNC:47299
Mus musculus	TFG	MGD	MGI:1338041
Felis catus	TFG	VGNC	VGNC:66122
Others	TFG	NCBI