TFG - trafficking from ER to golgi regulator Gene
Also Known as TF6; HMSNP; SPG57; TRKT3
Species: Homo sapiens
About TFG
This gene has 36 transcripts (splice variants), 217 orthologues and is associated with 67 phenotypes. Ubiquitous expression in duodenum (RPKM 35.2), placenta (RPKM 33.3) and 25 other tissues.
Summary
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
TFG Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001007565.2 | NP_001007566.1 | protein TFG isoform 1 |
| NM_001195478.2 | NP_001182407.1 | protein TFG isoform 1 |
| NM_001195479.2 | NP_001182408.1 | protein TFG isoform 2 |
| NM_006070.6 | NP_006061.2 | protein TFG isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
16169070 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in endoplasmic reticulum to Golgi vesicle-mediated transport |
IMP
IMP: Inferred from mutant phenotype
|
21478858 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in endoplasmic reticulum exit site |
IDA
IDA: Inferred from direct assay
|
21478858 | GOA |
TFG Protein Structure
PB1: PB1 domain (12 - 90)
- 0
- 100
- 200
- 300
- 400 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein TFG |
|
TFG Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TFG | Q92734 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
TFG | Q92734 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
TFG | Q92734 | ANXA11 | Homo sapiens | Q5T0G8 | 25416956 | |
|
Intra
|
TFG | Q92734 | ANXA11 | Homo sapiens | Q5T0G8 | 25416956 | |
|
Intra
|
TFG | Q92734 | ANXA11 | Homo sapiens | Q5T0G8 | 25416956 | |
|
Intra
|
TFG | Q92734 | NID2 | Homo sapiens | Q8IV28 | 32296183 | |
|
Intra
|
TFG | Q92734 | NID2 | Homo sapiens | Q8IV28 | 32296183 | |
|
Intra
|
TFG | Q92734 | ARHGEF16 | Homo sapiens | Q5VV41 | 25416956 | |
|
Intra
|
TFG | Q92734 | MSS51 | Homo sapiens | Q4VC12 | 32296183 | |
|
Intra
|
TFG | Q92734 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
TFG | Q92734 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
TFG | Q92734 | FAM168A | Homo sapiens | Q92567-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | FAM168A | Homo sapiens | Q92567-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | BOLL | Homo sapiens | Q8N9W6-4 | 32296183 | |
|
Intra
|
TFG | Q92734 | BOLL | Homo sapiens | Q8N9W6-4 | 32296183 | |
|
Intra
|
TFG | Q92734 | SAXO4 | Homo sapiens | Q7Z5V6-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | SAXO4 | Homo sapiens | Q7Z5V6-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
TFG | Q92734 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
TFG | Q92734 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
TFG | Q92734 | TBX19 | Homo sapiens | O60806 | 32296183 | |
|
Intra
|
TFG | Q92734 | TBX19 | Homo sapiens | O60806 | 32296183 | |
|
Intra
|
TFG | Q92734 | SMUG1 | Homo sapiens | Q53HV7-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | SMUG1 | Homo sapiens | Q53HV7-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
TFG | Q92734 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
TFG | Q92734 | EYA2 | Homo sapiens | O00167-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | EYA2 | Homo sapiens | O00167-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
TFG | Q92734 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
TFG | Q92734 | STH | Homo sapiens | Q8IWL8 | 32296183 | |
|
Intra
|
TFG | Q92734 | STH | Homo sapiens | Q8IWL8 | 32296183 | |
|
Intra
|
TFG | Q92734 | FOXH1 | Homo sapiens | O75593 | 32296183 | |
|
Intra
|
TFG | Q92734 | FOXH1 | Homo sapiens | O75593 | 32296183 | |
|
Intra
|
TFG | Q92734 | ZMYM5 | Homo sapiens | Q9UJ78-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | ZMYM5 | Homo sapiens | Q9UJ78-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | ZMYM5 | Homo sapiens | Q9UJ78-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
TFG | Q92734 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
TFG | Q92734 | SF3A2 | Homo sapiens | Q15428 | 32296183 | |
|
Intra
|
TFG | Q92734 | SF3A2 | Homo sapiens | Q15428 | 32296183 | |
|
Intra
|
TFG | Q92734 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
TFG | Q92734 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
TFG | Q92734 | VPS37C | Homo sapiens | A5D8V6 | 25416956 | |
|
Intra
|
TFG | Q92734 | VPS37C | Homo sapiens | A5D8V6 | 32296183 | |
|
Intra
|
TFG | Q92734 | VPS37C | Homo sapiens | A5D8V6 | 25416956 | |
|
Intra
|
TFG | Q92734 | VPS37C | Homo sapiens | A5D8V6 | 25416956 | |
|
Intra
|
TFG | Q92734 | VPS37C | Homo sapiens | A5D8V6 | 32296183 | |
|
Intra
|
TFG | Q92734 | SF3B4 | Homo sapiens | Q15427 | 32296183 | |
|
Intra
|
TFG | Q92734 | SF3B4 | Homo sapiens | Q15427 | 32296183 | |
|
Intra
|
TFG | Q92734 | HNRNPF | Homo sapiens | P52597 | 25416956 | |
|
Intra
|
TFG | Q92734 | TFG | Homo sapiens | Q92734 | 32296183 | |
|
Intra
|
TFG | Q92734 | TFG | Homo sapiens | Q92734 | 32296183 | |
|
Intra
|
TFG | Q92734 | TFG | Homo sapiens | Q92734 | 25416956 | |
|
Intra
|
TFG | Q92734 | TFG | Homo sapiens | Q92734 | 16169070 | |
|
Intra
|
TFG | Q92734 | TFG | Homo sapiens | Q92734 | 27107012 | |
|
Intra
|
TFG | Q92734 | TFG | Homo sapiens | Q92734 | 32296183 | |
|
Intra
|
TFG | Q92734 | TFG | Homo sapiens | Q92734 | 27107012 | |
|
Intra
|
TFG | Q92734 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
TFG | Q92734 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
TFG | Q92734 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
TFG | Q92734 | KRTAP26-1 | Homo sapiens | Q6PEX3 | 32296183 | |
|
Intra
|
TFG | Q92734 | KRTAP26-1 | Homo sapiens | Q6PEX3 | 32296183 | |
|
Intra
|
TFG | Q92734 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
TFG | Q92734 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
TFG | Q92734 | CSTF2 | Homo sapiens | P33240 | 25416956 | |
|
Intra
|
TFG | Q92734 | CSTF2 | Homo sapiens | P33240 | 25416956 | |
|
Intra
|
TFG | Q92734 | ANXA11 | Homo sapiens | P50995 | 31515488 | |
|
Intra
|
TFG | Q92734 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
TFG | Q92734 | MAGED1 | Homo sapiens | Q9Y5V3 | 25416956 | |
|
Intra
|
TFG | Q92734 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
TFG | Q92734 | MAGED1 | Homo sapiens | Q9Y5V3 | 25416956 | |
|
Intra
|
TFG | Q92734 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
TFG | Q92734 | MAGED1 | Homo sapiens | Q9Y5V3 | 25416956 | |
|
Intra
|
TFG | Q92734 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
TFG | Q92734 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
TFG | Q92734 | PEF1 | Homo sapiens | Q9UBV8 | 32296183 | |
|
Intra
|
TFG | Q92734 | PEF1 | Homo sapiens | Q9UBV8 | 32296183 | |
|
Intra
|
TFG | Q92734 | PEF1 | Homo sapiens | Q9UBV8 | 32296183 | |
|
Intra
|
TFG | Q92734 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
TFG | Q92734 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
TFG | Q92734 | LENG8 | Homo sapiens | Q96PV6 | 32296183 | |
|
Intra
|
TFG | Q92734 | EWSR1 | Homo sapiens | Q01844 | 25416956 | |
|
Intra
|
TFG | Q92734 | DVL3 | Homo sapiens | Q92997 | 32296183 | |
|
Intra
|
TFG | Q92734 | DVL3 | Homo sapiens | Q92997 | 32296183 | |
|
Intra
|
TFG | Q92734 | DVL3 | Homo sapiens | Q92997 | 32296183 | |
|
Intra
|
TFG | Q92734 | PLSCR1 | Homo sapiens | O15162 | 16189514 | |
|
Intra
|
TFG | Q92734 | RBPMS | Homo sapiens | Q93062 | 25416956 | |
|
Intra
|
TFG | Q92734 | RBPMS | Homo sapiens | Q93062 | 25416956 | |
|
Intra
|
TFG | Q92734 | MAPK1IP1L | Homo sapiens | Q8NDC0 | 25416956 | |
|
Intra
|
TFG | Q92734 | MAPK1IP1L | Homo sapiens | Q8NDC0 | 25416956 | |
|
Intra
|
TFG | Q92734 | MAPK1IP1L | Homo sapiens | Q8NDC0 | 32296183 | |
|
Intra
|
TFG | Q92734 | MAPK1IP1L | Homo sapiens | Q8NDC0 | 25416956 | |
|
Intra
|
TFG | Q92734 | MAPK1IP1L | Homo sapiens | Q8NDC0 | 32296183 | |
|
Intra
|
TFG | Q92734 | SPG21 | Homo sapiens | Q9NZD8 | 25416956 | |
|
Intra
|
TFG | Q92734 | SPG21 | Homo sapiens | Q9NZD8 | 25416956 | |
|
Intra
|
TFG | Q92734 | SPMIP9 | Homo sapiens | Q96LM6 | 32296183 | |
|
Intra
|
TFG | Q92734 | SPMIP9 | Homo sapiens | Q96LM6 | 32296183 | |
|
Intra
|
TFG | Q92734 | SPMIP9 | Homo sapiens | Q96LM6 | 32296183 | |
|
Intra
|
TFG | Q92734 | CEP55 | Homo sapiens | Q53EZ4 | 32296183 | |
|
Intra
|
TFG | Q92734 | CEP55 | Homo sapiens | Q53EZ4 | 32296183 | |
|
Intra
|
TFG | Q92734 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
TFG | Q92734 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
TFG | Q92734 | INTS11 | Homo sapiens | Q5TA45 | 32296183 | |
|
Intra
|
TFG | Q92734 | INTS11 | Homo sapiens | Q5TA45 | 32296183 | |
|
Intra
|
TFG | Q92734 | NADSYN1 | Homo sapiens | Q6IA69 | 32296183 | |
|
Intra
|
TFG | Q92734 | NADSYN1 | Homo sapiens | Q6IA69 | 32296183 | |
|
Intra
|
TFG | Q92734 | SEC24A | Homo sapiens | O95486 | 25416956 | |
|
Intra
|
TFG | Q92734 | SEC24A | Homo sapiens | O95486 | 25416956 | |
|
Intra
|
TFG | Q92734 | METTL27 | Homo sapiens | Q8N6F8 | 32296183 | |
|
Intra
|
TFG | Q92734 | METTL27 | Homo sapiens | Q8N6F8 | 32296183 | |
|
Intra
|
TFG | Q92734 | LASP1 | Homo sapiens | Q14847-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | LASP1 | Homo sapiens | Q14847-2 | 32296183 | |
|
Intra
|
TFG | Q92734 | POU2AF1 | Homo sapiens | Q16633 | 32296183 | |
|
Intra
|
TFG | Q92734 | POU2AF1 | Homo sapiens | Q16633 | 32296183 | |
|
Intra
|
TFG | Q92734 | PLEKHG4 | Homo sapiens | Q58EX7 | 32296183 | |
|
Intra
|
TFG | Q92734 | PLEKHG4 | Homo sapiens | Q58EX7 | 32296183 | |
|
Intra
|
TFG | Q92734 | BPIFA1 | Homo sapiens | Q9NP55 | 32296183 | |
|
Intra
|
TFG | Q92734 | BPIFA1 | Homo sapiens | Q9NP55 | 32296183 | |
|
Intra
|
TFG | Q92734 | BPIFA1 | Homo sapiens | Q9NP55 | 32296183 | |
|
Intra
|
TFG | Q92734 | BOLL | Homo sapiens | Q8N9W6 | 25416956 | |
|
Intra
|
TFG | Q92734 | BOLL | Homo sapiens | Q8N9W6 | 25416956 |
TFG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82536 | TRK fused gene Antibody (YA2281) | WB, IHC-F, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P82536A | TRK fused gene Antibody (YA2281)(PBS only) | WB, IHC-F, IHC-P, ICC/IF | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spastic Paraplegia 57, Autosomal Recessive |
|
|
| Neuropathy, Hereditary Motor And Sensory, Okinawa Type |
|
|
| Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Tfg Mutation |
|
|
| Chondrosarcoma, Extraskeletal Myxoid |
|
|
| Differentiated Thyroid Carcinoma |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Anaplastic Large Cell Lymphoma |
|
|
| Chondrosarcoma |
|
|
| Occipital Lobe Neoplasm |
|
|
| Paraplegia |
|
|
| Lymphoma |
|
|
| Dental Fluorosis |
|
|
| Bone Chondrosarcoma |
|
|
| Spondylometaphyseal Dysplasia, Corner Fracture Type |
|
|
| Inflammatory Myofibroblastic Tumor |
|
|
| Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive |
|
|
| Hereditary Spastic Paraplegia |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | TFG | RGD | RGD:1309751 |
| Macaca mulatta | TFG | VGNC | VGNC:82715 |
| Canis familiaris | TFG | VGNC | VGNC:47299 |
| Mus musculus | TFG | MGD | MGI:1338041 |
| Felis catus | TFG | VGNC | VGNC:66122 |
| Others | TFG | NCBI |