CRX - cone-rod homeobox Gene

Also Known as CRD; LCA7; OTX3; CORD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1406

About CRX

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:47,821,937-47,843,324 (from NCBI)

This gene has 6 transcripts (splice variants), 118 orthologues, 50 paralogues and is associated with 8 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

CRX Products (1)

mRNA	Protein	Name
NM_000554.6	NP_000545.1	cone-rod homeobox protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10625658	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10625658	GOA
enables leucine zipper domain binding	IPI IPI: Inferred from physical interaction	10887186	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10625658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRX Protein Structure

Homeobox

TF_Otx

0
100
200
299 a.a.

Protein Preferred Names	Protein Names
cone-rod homeobox protein	orthodenticle homeobox 3

CRX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CRX	O43186	ROR2	Homo sapiens	A1L4F5	Y2H Prey Pooling	25416956
Intra	CRX	O43186	ROR2	Homo sapiens	A1L4F5	Validated Y2H	25416956
Intra	CRX	O43186	GCM2	Homo sapiens	O75603	Y2H Array	31515488
Intra	CRX	O43186	GCM2	Homo sapiens	O75603	Y2H Prey Pooling	25416956
Intra	CRX	O43186	GCM2	Homo sapiens	O75603	Y2H Array	25416956
Intra	CRX	O43186	GCM2	Homo sapiens	O75603	Validated Y2H	25416956
Intra	CRX	O43186	GCM2	Homo sapiens	O75603	Y2H Array	29892012
Intra	CRX	O43186	GCM2	Homo sapiens	O75603	Validated Y2H	32296183
Intra	CRX	O43186	LIMS4	Homo sapiens	P0CW20	Validated Y2H	32296183
Intra	CRX	O43186	ZNF483	Homo sapiens	Q6P088	Validated Y2H	32296183
Intra	CRX	O43186	SZT2	Homo sapiens	Q5T011-5	Validated Y2H	25416956
Intra	CRX	O43186	LARP4	Homo sapiens	Q71RC2-6	Validated Y2H	25416956
Intra	CRX	O43186	PID1	Homo sapiens	Q7Z2X4	Validated Y2H	25416956
Intra	CRX	O43186	PID1	Homo sapiens	Q7Z2X4	Y2H Array	25416956
Intra	CRX	O43186	NEIL2	Homo sapiens	Q969S2	Validated Y2H	32296183
Intra	CRX	O43186	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	31515488
Intra	CRX	O43186	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	25416956
Intra	CRX	O43186	SEC14L4	Homo sapiens	Q9UDX3	Validated Y2H	32296183
Intra	CRX	O43186	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
Intra	CRX	O43186	PRKAB2	Homo sapiens	O43741	Validated Y2H	32296183
Intra	CRX	O43186	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	CRX	O43186	PRKAB2	Homo sapiens	O43741	Y2H Array	31515488
Intra	CRX	O43186	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	CRX	O43186	SOX10	Homo sapiens	P56693	Validated Y2H	32296183
Intra	CRX	O43186	LGALS3	Homo sapiens	P17931	Validated Y2H	32296183
Intra	CRX	O43186	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	CRX	O43186	TCF7L2	Homo sapiens	Q9NQB0-10	Validated Y2H	32296183
Intra	CRX	O43186	SOX5	Homo sapiens	P35711-4	Validated Y2H	32296183
Intra	CRX	O43186	IGFN1	Homo sapiens	Q86VF2-5	Validated Y2H	32296183
Intra	CRX	O43186	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
Intra	CRX	O43186	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	CRX	O43186	ZIC1	Homo sapiens	Q15915	Validated Y2H	32296183
Intra	CRX	O43186	BANF2	Homo sapiens	Q9H503-2	Validated Y2H	32296183
Intra	CRX	O43186	PRR35	Homo sapiens	P0CG20	Validated Y2H	32296183
Intra	CRX	O43186	FAAP20	Homo sapiens	Q6NZ36-4	Validated Y2H	32296183
Intra	CRX	O43186	MENT	Homo sapiens	Q9BUN1	Validated Y2H	32296183
Intra	CRX	O43186	SMAP1	Homo sapiens	Q8IYB5-2	Validated Y2H	32296183
Intra	CRX	O43186	CIMIP4	Homo sapiens	O43247-2	Validated Y2H	32296183
Intra	CRX	O43186	IRX6	Homo sapiens	P78412	Validated Y2H	32296183
Intra	CRX	O43186	BOD1L2	Homo sapiens	Q8IYS8	Validated Y2H	32296183
Intra	CRX	O43186	OR6B1	Homo sapiens	O95007	Validated Y2H	32296183
Intra	CRX	O43186	FOXH1	Homo sapiens	O75593	Validated Y2H	32296183
Intra	CRX	O43186	UBXN7	Homo sapiens	O94888	Validated Y2H	32296183
Intra	CRX	O43186	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	CRX	O43186	LONRF1	Homo sapiens	Q17RB8	Y2H Array	25416956
Intra	CRX	O43186	LONRF1	Homo sapiens	Q17RB8	Y2H Prey Pooling	25416956
Intra	CRX	O43186	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	CRX	O43186	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	CRX	O43186	HNF1B	Homo sapiens	P35680	Validated Y2H	32296183
Intra	CRX	O43186	DELE1	Homo sapiens	Q14154	Validated Y2H	25416956
Intra	CRX	O43186	SMAP2	Homo sapiens	Q8WU79	Validated Y2H	32296183
Intra	CRX	O43186	TBX6	Homo sapiens	O95947	Validated Y2H	32296183
Intra	CRX	O43186	C1orf50	Homo sapiens	Q9BV19	Validated Y2H	32296183
Intra	CRX	O43186	C9orf72	Homo sapiens	Q96LT7	Validated Y2H	25416956
Intra	CRX	O43186	SOX5	Homo sapiens	P35711	Y2H Prey Pooling	25416956
Intra	CRX	O43186	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	CRX	O43186	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	CRX	O43186	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	32296183
Intra	CRX	O43186	EIF5A	Homo sapiens	P63241	Y2H Array	25416956
Intra	CRX	O43186	NTF4	Homo sapiens	P34130	Validated Y2H	32296183
Intra	CRX	O43186	SUOX	Homo sapiens	P51687	Y2H Prey Pooling	32296183
Intra	CRX	O43186	SUOX	Homo sapiens	P51687	Validated Y2H	32296183
Intra	CRX	O43186	ATP6V0D2	Homo sapiens	Q8N8Y2	Validated Y2H	32296183
Intra	CRX	O43186	TLX3	Homo sapiens	O43711	Validated Y2H	32296183
Intra	CRX	O43186	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	25416956
Intra	CRX	O43186	MLLT6	Homo sapiens	Q6P2C6	Validated Y2H	25416956
Intra	CRX	O43186	PSMB10	Homo sapiens	P40306	Y2H Array	25416956
Intra	CRX	O43186	ROR2	Homo sapiens	Q01974	Validated Y2H	32296183
Intra	CRX	O43186	ARIH2	Homo sapiens	O95376	Validated Y2H	32296183
Intra	CRX	O43186	CDKN2C	Homo sapiens	P42773	Validated Y2H	32296183
Intra	CRX	O43186	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	CRX	O43186	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	CRX	O43186	CA8	Homo sapiens	P35219	Validated Y2H	25416956
Intra	CRX	O43186	CA8	Homo sapiens	P35219	Y2H Array	25416956
Intra	CRX	O43186	PNMA6A	Homo sapiens	P0CW24	Y2H Prey Pooling	32296183
Intra	CRX	O43186	PNMA6A	Homo sapiens	P0CW24	Validated Y2H	32296183
Intra	CRX	O43186	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	CRX	O43186	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	CRX	O43186	GYS1	Homo sapiens	P13807	Validated Y2H	32296183
Intra	CRX	O43186	SUFU	Homo sapiens	Q9UMX1	Validated Y2H	32296183
Intra	CRX	O43186	AASDHPPT	Homo sapiens	Q9NRN7	Validated Y2H	32296183
Intra	CRX	O43186	C19orf25	Homo sapiens	Q9UFG5	Validated Y2H	32296183
Intra	CRX	O43186	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183
Intra	CRX	O43186	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	CRX	O43186	SAE1	Homo sapiens	Q9UBE0	Validated Y2H	32296183
Intra	CRX	O43186	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	CRX	O43186	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	CRX	O43186	ABI2	Homo sapiens	Q9NYB9	Y2H Prey Pooling	25416956
Intra	CRX	O43186	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	CRX	O43186	ATG12	Homo sapiens	O94817	Validated Y2H	25416956
Intra	CRX	O43186	ATG12	Homo sapiens	O94817	Y2H Array	25416956
Intra	CRX	O43186	ATG12	Homo sapiens	O94817	Y2H Prey Pooling	25416956
Intra	CRX	O43186	M1AP	Homo sapiens	Q8TC57	Y2H Pooling	16189514
Intra	CRX	O43186	M1AP	Homo sapiens	Q8TC57	Validated Y2H	32296183
Intra	CRX	O43186	NIP7	Homo sapiens	Q9Y221	Y2H Array	25416956
Intra	CRX	O43186	CFAP206	Homo sapiens	Q8IYR0	Validated Y2H	32296183
Intra	CRX	O43186	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	CRX	O43186	GUCD1	Homo sapiens	Q96NT3	Validated Y2H	25416956
Intra	CRX	O43186	GUCD1	Homo sapiens	Q96NT3	Y2H Prey Pooling	25416956
Intra	CRX	O43186	OSGIN1	Homo sapiens	Q9UJX0	Y2H Prey Pooling	25416956
Intra	CRX	O43186	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	25416956
Intra	CRX	O43186	SOX3	Homo sapiens	P41225	Validated Y2H	32296183
Intra	CRX	O43186	SOX14	Homo sapiens	O95416	Validated Y2H	32296183
Intra	CRX	O43186	ATXN1	Homo sapiens	P54253	Validated Y2H	32296183
Intra	CRX	O43186	TNS2	Homo sapiens	Q63HR2	Validated Y2H	32296183
Cross	CRX	O43186	tax	Human T-cell leukemia virus	P03410	MAPPIT	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

CRX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81439	CRX Antibody (YA1184)	IHC-P, mIHC	Human, Rat
HY-P81439A	CRX Antibody (YA1184)(PBS only)	IHC-P, mIHC	Human, Rat

Related Diseases

Diseases	Alias
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Leber Congenital Amaurosis 7	LCA7 Leber Congenital Amaurosis, Type 7
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Macular Dystrophy, Concentric Annular	Mcdca Maculopathy, Bull'S Eye
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa 91	Benign Concentric Annular Macular Dystrophy RP91 Macular Dystrophy, Concentric Annular, Formerly Mcdca, Formerly Macular Dystrophy, Benign Concentric Annular, Formerly Bcamd, Formerly Bcamd Macular Dystrophy, Benign Concentric Annular Macular Dystrophy, Concentric Annular Mcdca Retinitis Pigmentosa, Type 91
Leber Congenital Amaurosis 1	LCA1 Amaurosis Congenita Of Leber I Lca Retinal Blindness, Congenital Crb Leber Congenital Amaurosis Type I Leber Congenital Amaurosis, Type 1 Amaurosis Congenita Of Leber, Type 1
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Stargardt Disease	Stargardt Disease 1 Stargardt Macular Dystrophy Stargardt Disease-1 Juvenile Onset Macular Degeneration Stargardt Macular Degeneration Juvenile Macular Degeneration Macular Dystrophy With Flecks, Type 1 Stgd Fundus Flavimaculatus Stargardt 1 Stargardts Disease
Enhanced S-Cone Syndrome	Goldmann-Favre Syndrome ESCS Favre Hyaloideoretinal Degeneration Retinoschisis With Early Hemeralopia Retinoschisis With Early Nyctalopia Enhanced S Cone Syndrome S-Cone Syndrome, Enhanced
Stargardt Disease 1	Fundus Flavimaculatus STGD1 Retinal Dystrophy, Early-Onset Severe Macular Dystrophy With Flecks, Type 1 Stargardt'S Disease Stgd Macular Degeneration, Juvenile Macular Degeneration Juvenile FFM Juvenile Macular Degeneration Macular Dystrophy With Flecks Type 1 Early Onset And Severe Retinal Dystrophy
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Retinal Degeneration	Degeneration Of Retina
Cone-Rod Dystrophy 11	CORD11 Dystrophy, Cone-Rod, Type 11
Retinoschisis 1, X-Linked, Juvenile	Retinoschisis X-Linked Retinoschisis X-Linked Juvenile Retinoschisis RS1 XLRS1 X-Linked Juvenile Retinoschisis 1 Xlrs Retinoschisis, X-Linked Rs Congenital X-Linked Retinoschisis Degenerative Retinoschisis Juvenile Retinoschisis Xjr Retinoschisis Juvenile X-Linked 1 Retinoschisis, Juvenile, X-Linked Retinoschisis, Degenerative
Intraocular Retinoblastoma	Pediatric Intraocular Retinoblastoma
Leber Congenital Amaurosis 4	LCA4 Retinitis Pigmentosa, Juvenile Cone-Rod Dystrophy Leber Congenital Amaurosis, Type 4 Retinitis Pigmentosa
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Hereditary Choroidal Atrophy	Hereditary Choroidal Dystrophy
Partial Central Choroid Dystrophy	Choroidal Dystrophy, Central Areolar
Leber Congenital Amaurosis 3	LCA3 Retinitis Pigmentosa 94, Variable Age At Onset, Autosomal Recessive Leber Congenital Amaurosis, Type 3 Leber Congenital Amaurosis Type 3
Retinal Cone Dystrophy 1	RCD1 Retinal Cone Dystrophy-1 Retinal Cone Degeneration Cone Dystrophy, Autosomal Dominant Cone Dystrophy Autosomal Dominant Doid:0081024
Leber Congenital Amaurosis 8	LCA8 Leber Congenital Amaurosis, Type 8
Leber Congenital Amaurosis 10	LCA10 Leber Congenital Amaurosis, Type 10
Unilateral Retinoblastoma
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Choroidal Dystrophy, Central Areolar, 1	Choroidal Sclerosis Choroidal Dystrophy Choroidal Dystrophy, Central Areolar Cacd Central Areolar Choroidal Dystrophy CACD1 Choroidal Dystrophy, Central Areolar 1 Choroidal Dystrophy Central Areolar Central Areolar Choroidal Sclerosis Choroidal Degenerations Areolar Atrophy Of The Macula Partial Central Choroid Dystrophy Degenerative Choroidopathy Chorioretinal Degeneration Hereditary Chorioretinal Degeneration Hereditary Degeneration Of Choroid Hereditary Choroidal Dystrophies Generalised Choroidal Dystrophy Hereditary Choroidopathy
Eye Degenerative Disease
Leber Congenital Amaurosis 9	LCA9 Leber Congenital Amaurosis, Type 9
Leber Congenital Amaurosis 6	LCA6 Leber Congenital Amaurosis, Type 6
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Retinitis Pigmentosa 9	RP9 Retinitis Pigmentosa-9 Retinitis Pigmentosa, Type 9
Retinitis Pigmentosa 1	RP1 Retinitis Pigmentosa-1 Retinitis Pigmentosa, Type 1
Spinocerebellar Ataxia 7	Spinocerebellar Ataxia Type 7 SCA7 Opca3 Opca Iii Olivopontocerebellar Atrophy Iii Opca With Retinal Degeneration Opca With Macular Degeneration And External Ophthalmoplegia Adca, Type Ii Autosomal Dominant Cerebellar Ataxia Type 2 Olivopontocerebellar Atrophy 3 Autosomal Dominant Cerebellar Ataxia, Type Ii Autosomal Dominant Cerebellar Ataxia Type Ii Adca2 Adcaii Ataxia With Pigmentary Retinopathy Cerebellar Syndrome-Pigmentary Maculopathy Syndrome Olivopontocerebellar Atrophy With Retinal Degeneration Spinocerebellar Ataxia-7 Ataxia, Spinocerebellar, Type 7
Cone-Rod Dystrophy 3	CORD3 Dystrophy, Cone Rod, Type 3
Pineoblastoma	Pineal Pnet Pinealoma Pineal Gland Neoplasm Pineocytoma Tumor Of The Pineal Region
Leber Congenital Amaurosis 2	LCA2 Amaurosis Congenita Of Leber Ii Amaurosis Congenita Of Leber, Type 2 Leber Congenital Amaurosis Type Ii Leber Congenital Amaurosis, Type 2 Leber Congenital Amaurosis, Type Ii
Thyroid Hormone Resistance, Selective Pituitary	PRTH Selective Pituitary Thyroid Hormone Resistance Selective Pituitary Resistance To Thyroid Hormone Familial Hyperthyroidism Due To Inappropriate Thyrotropin Secretion Hyperthyroidism, Familial, Due To Inappropriate Thyrotropin Secretion Pituitary Resistance To Thyroid Hormone
Pineal Gland Cancer	Tumor Of The Pineal Region Malignant Pineal Region Tumor Malignant Tumor Of Pineal Gland Neoplasm Of Pineal Gland Neoplasm Of The Pineal Region Pineal Body Neoplasm Pineocytic Tumor Malignant Neoplasm Of Pineal Gland Pineal Gland Neoplasm Pineocytoma
Occult Macular Dystrophy	OCMD Omd Dystrophy, Macular, Occult
Diamond-Blackfan Anemia 6	DBA6 Aase-Smith Syndrome Ii Aase Syndrome Aase Smith Syndrome 2 Rpl5-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 6 Diamond-Blackfan Anemia 1
Retinitis Pigmentosa 33	RP33 Retinitis Pigmentosa, Type 33
Pseudopapilledema
Vitelliform Macular Dystrophy	Best Disease Juvenile-Onset Vitelliform Macular Dystrophy Macular Dystrophy, Vitelliform Best Macular Dystrophy Vitelliform Dystrophy
Degeneration Of Macula And Posterior Pole	Degeneration Of Macula And Posterior Pole Of Retina Degeneration Of Macula Or Posterior Pole Macular Degeneration Nos Degenerative Disorder Of Macula Drusen Macular Degeneration Posterior Pole Macular Degeneration Of Eye Macular Eye Degeneration Macular Degeneration Of Retina, Unspecified Pseudohole Degeneration Of Macula Of Retina
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Achromatopsia	Achm Rod Monochromatism Total Color Blindness Rod Monochromacy Monochromatism Achromatism Complete Or Incomplete Color Blindness Pingelapese Blindness Achromatopsia 1 Achromatopsia 2 Achromatopsia 3
Fundus Albipunctatus	Retinitis Punctata Albescens Pigmentary Retinal Dystrophy RPA Albipunctate Retinal Dystrophy Lauber'S Disease FALBI Fa
Color Blindness	Color Vision Defect Blindness Color Colour Blindness Colour Vision Deficiency Color Vision Deficiency Color Vision Defects Defective Color Vision Vision Defect, Color Color-Vision Disease Dyschromatopsia
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Senior-Loken Syndrome 1	Senior-Loken Syndrome Renal Dysplasia And Retinal Aplasia Renal-Retinal Syndrome Loken-Senior Syndrome Juvenile Nephronophthisis With Leber Amaurosis SLSN1 Senior-Loken Syndrome-1 Loken Senior Syndrome Senior Loken Syndrome Renal Dysplasia Retinal Aplasia Nephronophthisis With Retinal Dystrophy Renal Dysplasia-Retinal Aplasia Syndrome Slsn
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Night Blindness	Nyctalopia
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
Late-Onset Retinal Degeneration	LORD Retinal Degeneration, Late-Onset, Autosomal Dominant Autosomal Dominant Late-Onset Retinal Degeneration Pigmentary Retinopathy Retinal Degeneration, Late-Onset Retinitis Pigmentosa
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH
Sensory System Disease
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111792	GSK1795091	Agonist	94.48%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153759	CRX000227	Modulator	95.0%	Unkown
HY-155801	CRX 527		/	Unkown
HY-RS03203	CRX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118984	CRX-526	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CRX	VGNC	VGNC:109611
Rattus norvegicus	CRX	RGD	RGD:620511
Canis familiaris	CRX	VGNC	VGNC:39632
Mus musculus	CRX	MGD	MGI:1194883
Others	CRX	NCBI