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UBXN7 - UBX domain protein 7 Gene

Also Known as UBXD7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26043

About UBXN7

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,347,662-196,432,427 (from NCBI)

This gene has 6 transcripts (splice variants), 174 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues.

Summary

Enables ubiquitin binding activity and ubiquitin protein Ligase binding activity. Located in nuclear body. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN7 Products (1)

mRNA	Protein	Name
NM_015562.2	NP_056377.1	UBX domain-containing protein 7

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18775313	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18775313	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	18775313	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	18775313	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: Inferred from direct assay	18775313	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN7 Protein Structure

UBA_4

Thioredoxin_7

UBX

0
100
200
300
400
489 a.a.

Protein Preferred Names	Protein Names
UBX domain-containing protein 7	UBX domain containing 7

UBXN7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBXN7	O94888	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	UBXN7	O94888	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	UBXN7	O94888	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	UBXN7	O94888	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	UBXN7	O94888	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	NFYC	Homo sapiens	Q13952-2	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
Intra	UBXN7	O94888	NFYC	Homo sapiens	Q13952-2	Y2H Array	32296183
Intra	UBXN7	O94888	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	UBXN7	O94888	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	FAM168A	Homo sapiens	Q92567-2	Validated Y2H	32296183
Intra	UBXN7	O94888	CLEC19A	Homo sapiens	Q6UXS0	Validated Y2H	32296183
Intra	UBXN7	O94888	CLEC19A	Homo sapiens	Q6UXS0	Y2H Array	32296183
Intra	UBXN7	O94888	CLEC19A	Homo sapiens	Q6UXS0	Y2H Prey Pooling	32296183
Cross	UBXN7	O94888	Cul1	Mus musculus	Q9WTX6	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	ZNRF1	Homo sapiens	Q8ND25	Validated Y2H	32296183
Intra	UBXN7	O94888	ZNRF1	Homo sapiens	Q8ND25	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	ZNRF1	Homo sapiens	Q8ND25	Y2H Array	32296183
Intra	UBXN7	O94888	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	UBXN7	O94888	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	UBXN7	O94888	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	MEOX1	Homo sapiens	P50221	Validated Y2H	32296183
Intra	UBXN7	O94888	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	UBXN7	O94888	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
Intra	UBXN7	O94888	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	UBXN7	O94888	VCP	Homo sapiens	P55072	Anti Tag CoIP	33961781
Intra	UBXN7	O94888	VCP	Homo sapiens	P55072	Anti Tag CoIP	18775313
Intra	UBXN7	O94888	VCP	Homo sapiens	P55072	Validated Y2H	32296183
Intra	UBXN7	O94888	VCP	Homo sapiens	P55072	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	VCP	Homo sapiens	P55072	Y2H Array	32296183
Intra	UBXN7	O94888	VCP	Homo sapiens	P55072	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	32296183
Intra	UBXN7	O94888	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	32296183
Intra	UBXN7	O94888	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	18775313
Intra	UBXN7	O94888	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	UBXN7	O94888	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	18775313
Intra	UBXN7	O94888	CUL4B	Homo sapiens	Q13620	Anti Tag CoIP	18775313
Intra	UBXN7	O94888	CUL4B	Homo sapiens	Q13620	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	CUL4A	Homo sapiens	Q13619	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	CUL4A	Homo sapiens	Q13619	Anti Tag CoIP	18775313
Intra	UBXN7	O94888	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	18775313
Intra	UBXN7	O94888	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	18775313
Intra	UBXN7	O94888	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	UBXN7	O94888	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	UBXN7	O94888	NEDD8	Homo sapiens	Q15843	Anti Tag CoIP	22466964
Intra	UBXN7	O94888	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBXN7	O94888	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	UBXN7	O94888	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	UBXN7	O94888	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	UBXN7	O94888	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	UBXN7	O94888	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	PAX6	Homo sapiens	P26367	Validated Y2H	32296183
Intra	UBXN7	O94888	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	UBXN7	O94888	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	UBXN7	O94888	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	UBXN7	O94888	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	UBXN7	O94888	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 46	Tfrc-Related Combined Immunodeficiency IMD46 Cid Due To Tfrc Deficiency Combined Immunodeficiency Due To Tfrc Deficiency
Chromosome 3q29 Deletion Syndrome	Chromosome 3q29 Microdeletion Syndrome 3q29 Microdeletion Syndrome 3q Subtelomere Deletion Syndrome 3q29 Recurrent Deletion 3qter Deletion 3q29 Deletion Syndrome Monosomy 3q29 Microdeletion 3q29 Syndrome Del(3)(Q29) Monosomy 3qter 3q29 Deletion Del3q29
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15399	UBXN7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBXN7	VGNC	VGNC:36629
Rattus norvegicus	UBXN7	RGD	RGD:1306346
Macaca mulatta	UBXN7	VGNC	VGNC:79778
Canis familiaris	UBXN7	VGNC	VGNC:48102
Felis catus	UBXN7	VGNC	VGNC:102862
Mus musculus	UBXN7	MGD	MGI:2146388
Others	UBXN7	NCBI