CUL3 - cullin 3 Gene

Also Known as CUL-3; PHA2E; NEDAUS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8452

About CUL3

Cytogenetic location: 2q36.2 Genomic coordinates (GRCh38): 2:224,470,150-224,585,363 (from NCBI)

This gene has 15 transcripts (splice variants), 293 orthologues, 7 paralogues and is associated with 77 phenotypes. Broad expression in testis (RPKM 53.6), esophagus (RPKM 12.6) and 24 other tissues.

Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin Ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

CUL3 Products (3)

mRNA	Protein	Name
NM_001257197.2	NP_001244126.1	cullin-3 isoform 2
NM_001257198.2	NP_001244127.1	cullin-3 isoform 3
NM_003590.5	NP_003581.1	cullin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	25401743	GOA
enables POZ domain binding	IDA IDA: Inferred from direct assay	14528312	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12609982	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	23453970	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	14528312	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	14528312	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	15983046	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in COPII vesicle coating	IMP IMP: Inferred from mutant phenotype	22358839	GOA
acts upstream of or within anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	10500095	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	29769719	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	22358839	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	17543862	GOA
involved in negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	36394357	GOA
involved in nuclear protein quality control by the ubiquitin-proteasome system	IDA IDA: Inferred from direct assay	27561354	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	29769719	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	19261606	GOA
involved in positive regulation of mitotic cell cycle phase transition	IMP IMP: Inferred from mutant phenotype	23213400	GOA
involved in positive regulation of mitotic metaphase/anaphase transition	IMP IMP: Inferred from mutant phenotype	17543862	GOA
involved in positive regulation of protein ubiquitination	IGI IGI: Inferred from genetic interaction	24844779	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19261606	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25684205	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	25684205	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	14528312	GOA
involved in protein destabilization	IGI IGI: Inferred from genetic interaction	24844779	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	22358839	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	14528312	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	17543862	GOA
involved in regulation of cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	27708159	GOA
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	19782033	GOA
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25401743	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	27561354	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14528312	GOA
located in centrosome	IDA IDA: Inferred from direct assay	23213400	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	27708159	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28395323	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	23213400	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23213400	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19617556	GOA
located in polar microtubule	IDA IDA: Inferred from direct assay	19995937	GOA
located in sperm flagellum	IDA IDA: Inferred from direct assay	28395323	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	23213400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL3 Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
768 a.a.

Protein Preferred Names	Protein Names
cullin-3

CUL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CUL3	Q13618	ZMAT4	Homo sapiens	Q9H898-2	Validated Y2H	32296183
Intra	CUL3	Q13618	ZMAT4	Homo sapiens	Q9H898-2	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	ZMAT4	Homo sapiens	Q9H898-2	Y2H Array	32296183
Intra	CUL3	Q13618	KCTD7	Homo sapiens	Q96MP8-2	Y2H Array	32296183
Intra	CUL3	Q13618	KCTD7	Homo sapiens	Q96MP8-2	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	KCTD7	Homo sapiens	Q96MP8-2	Validated Y2H	32296183
Intra	CUL3	Q13618	BTBD6	Homo sapiens	Q96KE9-2	Validated Y2H	32296183
Intra	CUL3	Q13618	BTBD6	Homo sapiens	Q96KE9-2	Y2H Array	32296183
Intra	CUL3	Q13618	BTBD6	Homo sapiens	Q96KE9-2	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	KLHL13	Homo sapiens	Q9P2N7	TAP	21145461
Intra	CUL3	Q13618	KLHL13	Homo sapiens	Q9P2N7	Anti Tag CoIP	30190310
Intra	CUL3	Q13618	KLHL13	Homo sapiens	Q9P2N7	Anti Bait CoIP	17543862
Intra	CUL3	Q13618	KLHL13	Homo sapiens	Q9P2N7	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KLHL13	Homo sapiens	Q9P2N7	Pull Down	17543862
Intra	CUL3	Q13618	KLHL13	Homo sapiens	Q9P2N7	Anti Bait CoIP	30190310
Intra	CUL3	Q13618	KBTBD8	Homo sapiens	Q8NFY9	TAP	21145461
Intra	CUL3	Q13618	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	25416956
Intra	CUL3	Q13618	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	TNFAIP1	Homo sapiens	Q13829	TAP	21145461
Intra	CUL3	Q13618	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	33961781
Intra	CUL3	Q13618	KCTD10	Homo sapiens	Q9H3F6	Anti Tag CoIP	33961781
Intra	CUL3	Q13618	KCTD10	Homo sapiens	Q9H3F6	TAP	21145461
Intra	CUL3	Q13618	KCTD10	Homo sapiens	Q9H3F6	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KCTD10	Homo sapiens	Q9H3F6	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	KCTD10	Homo sapiens	Q9H3F6	Validated Y2H	32296183
Intra	CUL3	Q13618	KCTD10	Homo sapiens	Q9H3F6	Y2H Array	32296183
Intra	CUL3	Q13618	KLHL9	Homo sapiens	Q9P2J3	Anti Tag CoIP	30190310
Intra	CUL3	Q13618	KLHL9	Homo sapiens	Q9P2J3	Anti Bait CoIP	17543862
Intra	CUL3	Q13618	KLHL9	Homo sapiens	Q9P2J3	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KLHL9	Homo sapiens	Q9P2J3	Pull Down	17543862
Intra	CUL3	Q13618	KLHL9	Homo sapiens	Q9P2J3	TAP	21145461
Intra	CUL3	Q13618	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	25416956
Intra	CUL3	Q13618	KCTD6	Homo sapiens	Q8NC69	TAP	21145461
Intra	CUL3	Q13618	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	25416956
Intra	CUL3	Q13618	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	32296183
Intra	CUL3	Q13618	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	CUL3	Q13618	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	GMCL1	Homo sapiens	Q96IK5	Y2H Array	31515488
Intra	CUL3	Q13618	GMCL1	Homo sapiens	Q96IK5	TAP	21145461
Intra	CUL3	Q13618	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	CUL3	Q13618	ZMAT4	Homo sapiens	Q9H898	Y2H Prey Pooling	25416956
Intra	CUL3	Q13618	KLHL5	Homo sapiens	Q96PQ7	Y2H	21988832
Intra	CUL3	Q13618	KLHL5	Homo sapiens	Q96PQ7	TAP	21145461
Intra	CUL3	Q13618	KLHL5	Homo sapiens	Q96PQ7	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	ELOC	Homo sapiens	Q15369	Y2H Array	21988832
Intra	CUL3	Q13618	ELOC	Homo sapiens	Q15369	TAP	21145461
Intra	CUL3	Q13618	BTBD3	Homo sapiens	Q9Y2F9	Validated Y2H	32296183
Intra	CUL3	Q13618	BTBD3	Homo sapiens	Q9Y2F9	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	BTBD3	Homo sapiens	Q9Y2F9	Y2H Array	32296183
Intra	CUL3	Q13618	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CUL3	Q13618	HSP90AB1	Homo sapiens	P08238	Anti Bait CoIP	37207277
Intra	CUL3	Q13618	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL3	Q13618	CKB	Homo sapiens	P12277	Anti Bait CoIP	37207277
Intra	CUL3	Q13618	CKB	Homo sapiens	P12277	TAP	21145461
Intra	CUL3	Q13618	CCDC22	Homo sapiens	O60826	Pull Down	23563313
Intra	CUL3	Q13618	RBX1	Homo sapiens	P62877	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	RBX1	Homo sapiens	P62877	Pull Down	17543862
Intra	CUL3	Q13618	RBX1	Homo sapiens	P62877	Pull Down	25619834
Intra	CUL3	Q13618	RBX1	Homo sapiens	P62877	GMS	37788672
Intra	CUL3	Q13618	RBX1	Homo sapiens	P62877	3D-EM	37788672
Intra	CUL3	Q13618	KCTD9	Homo sapiens	Q7L273	Validated Y2H	25416956
Intra	CUL3	Q13618	KCTD9	Homo sapiens	Q7L273	TAP	21145461
Intra	CUL3	Q13618	KCTD9	Homo sapiens	Q7L273	Validated Y2H	32296183
Intra	CUL3	Q13618	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	CUL3	Q13618	KCTD9	Homo sapiens	Q7L273	Y2H Array	32296183
Intra	CUL3	Q13618	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	25416956
Intra	CUL3	Q13618	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	CAND1	Homo sapiens	Q86VP6	TAP	21145461
Intra	CUL3	Q13618	CAND1	Homo sapiens	Q86VP6	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	CAND1	Homo sapiens	Q86VP6	CoIP	12609982
Intra	CUL3	Q13618	COPS5	Homo sapiens	Q92905	Anti Bait CoIP	37207277
Intra	CUL3	Q13618	COPS5	Homo sapiens	Q92905	TAP	21145461
Intra	CUL3	Q13618	KLHL7	Homo sapiens	Q8IXQ5	TAP	21145461
Intra	CUL3	Q13618	KLHL7	Homo sapiens	Q8IXQ5	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KLHL7	Homo sapiens	Q8IXQ5	Anti Tag CoIP	33961781
Intra	CUL3	Q13618	KLHL7	Homo sapiens	Q8IXQ5	Anti Tag CoIP	30190310
Intra	CUL3	Q13618	KLHL1	Homo sapiens	Q9NR64	Pull Down	22632832
Intra	CUL3	Q13618	KLHL1	Homo sapiens	Q9NR64	Anti Tag CoIP	30190310
Intra	CUL3	Q13618	BTBD2	Homo sapiens	Q9BX70	TAP	21145461
Intra	CUL3	Q13618	BTBD2	Homo sapiens	Q9BX70	Validated Y2H	32296183
Intra	CUL3	Q13618	BTBD2	Homo sapiens	Q9BX70	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	BTBD2	Homo sapiens	Q9BX70	Anti Bait CoIP	17543862
Intra	CUL3	Q13618	BTBD2	Homo sapiens	Q9BX70	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	BTBD2	Homo sapiens	Q9BX70	Y2H Array	32296183
Intra	CUL3	Q13618	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	20389280
Intra	CUL3	Q13618	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	30190310
Intra	CUL3	Q13618	KLHL20	Homo sapiens	Q9Y2M5	Pull Down	25619834
Intra	CUL3	Q13618	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KLHL20	Homo sapiens	Q9Y2M5	Pull Down	22632832
Intra	CUL3	Q13618	KLHL20	Homo sapiens	Q9Y2M5	TAP	21145461
Intra	CUL3	Q13618	IVNS1ABP	Homo sapiens	Q9Y6Y0	Pull Down	25619834
Intra	CUL3	Q13618	IVNS1ABP	Homo sapiens	Q9Y6Y0	Anti Tag CoIP	25619834
Intra	CUL3	Q13618	BTBD10	Homo sapiens	Q9BSF8	TAP	21145461
Intra	CUL3	Q13618	BTBD10	Homo sapiens	Q9BSF8	Anti Tag CoIP	33961781
Intra	CUL3	Q13618	BTBD10	Homo sapiens	Q9BSF8	Y2H	21988832
Intra	CUL3	Q13618	BTBD10	Homo sapiens	Q9BSF8	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	ABTB1	Homo sapiens	Q969K4	Y2H Prey Pooling	25416956
Intra	CUL3	Q13618	ABTB1	Homo sapiens	Q969K4	TAP	21145461
Intra	CUL3	Q13618	ABTB1	Homo sapiens	Q969K4	Y2H Array	25416956
Intra	CUL3	Q13618	ABTB1	Homo sapiens	Q969K4	Y2H Array	31515488
Intra	CUL3	Q13618	SHKBP1	Homo sapiens	Q8TBC3	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	SHKBP1	Homo sapiens	Q8TBC3	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	SHKBP1	Homo sapiens	Q8TBC3	Y2H Array	32296183
Intra	CUL3	Q13618	SHKBP1	Homo sapiens	Q8TBC3	TAP	21145461
Intra	CUL3	Q13618	SHKBP1	Homo sapiens	Q8TBC3	Validated Y2H	32296183
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	TAP	21145461
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Validated Y2H	25416956
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Anti Bait CoIP	30190310
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Y2H Array	25416956
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Anti Tag CoIP	30190310
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Pull Down	30190310
Intra	CUL3	Q13618	KLHL12	Homo sapiens	Q53G59	Anti Bait CoIP	17543862
Intra	CUL3	Q13618	KCTD13	Homo sapiens	Q8WZ19	Validated Y2H	32296183
Intra	CUL3	Q13618	KCTD13	Homo sapiens	Q8WZ19	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	KCTD13	Homo sapiens	Q8WZ19	Y2H Array	32296183
Intra	CUL3	Q13618	KCTD13	Homo sapiens	Q8WZ19	Y2H Prey Pooling	25416956
Intra	CUL3	Q13618	KCTD13	Homo sapiens	Q8WZ19	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KCTD13	Homo sapiens	Q8WZ19	TAP	21145461
Intra	CUL3	Q13618	SPOP	Homo sapiens	O43791	Y2H	21988832
Intra	CUL3	Q13618	SPOP	Homo sapiens	O43791	Anti Tag CoIP	33961781
Intra	CUL3	Q13618	SPOP	Homo sapiens	O43791	Pull Down	21577200
Intra	CUL3	Q13618	SPOP	Homo sapiens	O43791	Pull Down	22632832
Intra	CUL3	Q13618	KLHL2	Homo sapiens	O95198	TAP	21145461
Intra	CUL3	Q13618	KLHL2	Homo sapiens	O95198	Y2H Array	31515488
Intra	CUL3	Q13618	KLHL2	Homo sapiens	O95198	Anti Tag CoIP	33961781
Intra	CUL3	Q13618	KLHL2	Homo sapiens	O95198	Validated Y2H	25416956
Intra	CUL3	Q13618	KLHL2	Homo sapiens	O95198	Y2H Array	25416956
Intra	CUL3	Q13618	KLHL2	Homo sapiens	O95198	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	KEAP1	Homo sapiens	Q14145	Validated Y2H	32296183
Intra	CUL3	Q13618	KEAP1	Homo sapiens	Q14145	TAP	21145461
Intra	CUL3	Q13618	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	CUL3	Q13618	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	19427028
Intra	CUL3	Q13618	KLHL3	Homo sapiens	Q9UH77	Validated Y2H	32296183
Intra	CUL3	Q13618	KLHL3	Homo sapiens	Q9UH77	Y2H Array	25502805
Intra	CUL3	Q13618	KLHL3	Homo sapiens	Q9UH77	Y2H Array	32296183
Intra	CUL3	Q13618	KLHL3	Homo sapiens	Q9UH77	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	KLHL3	Homo sapiens	Q9UH77	Y2H Array	31515488
Intra	CUL3	Q13618	BTBD1	Homo sapiens	Q9H0C5	Validated Y2H	32296183
Intra	CUL3	Q13618	BTBD1	Homo sapiens	Q9H0C5	Y2H Array	32296183
Intra	CUL3	Q13618	BTBD1	Homo sapiens	Q9H0C5	Anti Bait CoIP	17543862
Intra	CUL3	Q13618	BTBD1	Homo sapiens	Q9H0C5	Anti Tag CoIP	34591642
Intra	CUL3	Q13618	BTBD1	Homo sapiens	Q9H0C5	Anti Bait CoIP	37207277
Intra	CUL3	Q13618	BTBD1	Homo sapiens	Q9H0C5	Y2H Prey Pooling	32296183
Intra	CUL3	Q13618	BTBD1	Homo sapiens	Q9H0C5	TAP	21145461
Intra	CUL3	Q13618	ACOT7	Homo sapiens	O00154	Crosslink	26949739
Intra	CUL3	Q13618	KLHL8	Homo sapiens	Q9P2G9	TAP	21145461
Intra	CUL3	Q13618	KLHL8	Homo sapiens	Q9P2G9	Anti Tag CoIP	33961781
Intra	CUL3	Q13618	KLHL8	Homo sapiens	Q9P2G9	Anti Tag CoIP	30190310
Intra	CUL3	Q13618	KLHL8	Homo sapiens	Q9P2G9	Anti Tag CoIP	34591642

Cross: Cross-species interaction Intra: Intraspecies interaction

CUL3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82833	Cullin 3 Antibody (YA2578)	WB, IP	Human, Mouse, Rat
HY-P82833A	Cullin 3 Antibody (YA2578)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pseudohypoaldosteronism, Type Iie	Pseudohypoaldosteronism Type 2e PHA2E Familial Hyperkalemic Hypertension Gordon'S Syndrome Phaii Pseudohypoaldosteronism Type 2 Gordon Hyperkalemia-Hypertension Syndrome Pseudohypoaldosteronism Type Ii Chloride Shunt Syndrome Hyperpotassemia And Hypertension Familial Pha2 Familial Hyperpotassemia And Hypertension Familial Hypertensive Hyperkalemia Fhht Hyperkalemia-Hypertension Syndrome, Gordon Type Hypertensive Hyperkalemia Mineralocorticoid Resistant Hyperkalemia Spitzer-Weinstein Syndrome Pseudohypoaldosteronism 2e Pseudohypoaldosteronism, Type Ii Pseudohypoaldosteronism, Type Iid Hyperpotassemia And Hypertension, Familial
Neurodevelopmental Disorder With Or Without Autism Or Seizures	NEDAUS Neurodevelopmental Disorder With Autism Without Seizures Neurodevelopmental Disorder Without Autism With Seizures Neurodevelopmental Disorder Without Autism Or Seizures Neurodevelopmental Disorder With/Without Autism Or Seizures
Pseudohypoaldosteronism, Type Iia	Pseudohypoaldosteronism Type 2a PHA2A Hyperpotassemia And Hypertension, Familial Hypertensive Hyperkalemia, Familial Gordon Hyperkalemia-Hypertension Syndrome Pseudohypoaldosteronism, Type Ii
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Pseudohypoaldosteronism, Type I, Autosomal Dominant	Autosomal Dominant Pseudohypoaldosteronism Type 1 PHA1A Pseudohypoaldosteronism Type I, Autosomal Dominant Pseudohypoaldosteronism Type 1 Autosomal Dominant Renal Pha1 Renal Pseudohypoaldosteronism Type 1 Pha I, Autosomal Dominant Autosomal Dominant Pha 1 Pseudohypoaldosteronism Type 1, Dominant Autosomal Dominant Pha1 Pseudohypoaldosteronism 1, Autosomal Dominant Pha Type I, Autosomal Dominant
Pseudohypoaldosteronism
Nk-Cell Enteropathy
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Cold-Induced Sweating Syndrome 3
Metabolic Acidosis
Giant Axonal Neuropathy 2
Arthrogryposis, Distal, Type 3	Gordon Syndrome DA3 Distal Arthrogryposis Type 3 Arthrogryposis Multiplex Congenita, Distal, Type Iia Camptodactyly, Cleft Palate, And Clubfoot Camptodactyly-Cleft Palate-Clubfoot Syndrome Distal Arthrogryposis Multiplex Congenita Type Iia Arthrogryposis Distal Type 3 Distal Arthrogryposis Type Iia Arthrogryposis, Distal, 3 Pseudohypoaldosteronism, Type Ii
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Penis Carcinoma In Situ	Carcinoma In Situ Of Penis Bowen'S Disease Of Penis Grade Iii Squamous Intraepithelial Lesion Of Penis Penile Intraepithelial Neoplasia Grade Iii Queyrat'S Erythroplasia Erythroplasia Of Queyrat Pin - [Penile Intraepithelial Neoplasia]
Renal Tubular Transport Disease	Renal Tubular Transport, Inborn Errors Inborn Renal Tubular Transport Disorder
Cold-Induced Sweating Syndrome	Crisponi Syndrome Sohar-Crisponi Syndrome Ciss Cntf Receptor-Related Disorders Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death Sweating Syndrome, Cold-Induced
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-159641	VVD-130037	Activator	99.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126075A	WS-383	Inhibitor	99.43%	Unkown
HY-169766	VVD 065	Degrader	99.71%	Unkown
HY-124834	Nrf2 activator-10		98.65%	Unkown
HY-RS03361	CUL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-126075	WS-383 free base	Inhibitor	/	Unkown
HY-RS18472	Cul3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24953	Cul3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CUL3	VGNC	VGNC:61284
Macaca mulatta	CUL3	VGNC	VGNC:71567
Canis familiaris	CUL3	VGNC	VGNC:39730
Mus musculus	CUL3	MGD	MGI:1347360
Bos taurus	CUL3	VGNC	VGNC:27831
Rattus norvegicus	CUL3	RGD	RGD:1308190
Others	CUL3	NCBI