2. Gene
  3. ABTB1 - ankyrin repeat and BTB domain containing 1 Gene

ABTB1 - ankyrin repeat and BTB domain containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BPOZ; BTB3; BTBD21; EF1ABP; PP2259

Gene ID: 80325 | Gene type: protein coding

About ABTB1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,672,952-127,680,926 (from NCBI)

This gene has 15 transcripts (splice variants), 185 orthologues and 11 paralogues. Ubiquitous expression in spleen (RPKM 23.0), bone marrow (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the Phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]

ABTB1 Products(2)

mRNA Protein Name
NM_032548.4 NP_115937.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 1
NM_172027.3 NP_742024.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 2

ABTB1 Protein Structure

Ank_5

Ank_5: Ankyrin repeats (many copies) (21 - 74)

BTB

BTB: BTB/POZ domain (105 - 208)

BTB

BTB: BTB/POZ domain (271 - 374)

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  • 478 a.a.
Protein Preferred Names Protein Names

ankyrin repeat and BTB/POZ domain-containing protein 1

ankyrin repeat and BTB (POZ) domain containing 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00115 ABTB1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ABTB1 RGD RGD:1359363
Mus musculus ABTB1 MGD MGI:1933148
Felis catus ABTB1 VGNC VGNC:59494
Macaca mulatta ABTB1 VGNC VGNC:69459
Bos taurus ABTB1 VGNC VGNC:25515
Canis familiaris ABTB1 VGNC VGNC:37486