EEF1A2 - eukaryotic translation elongation factor 1 alpha 2 Gene

Also Known as HS1; STN; EF1A; STNL; DEE33; MRD38; EEF1AL; EIEE33; EF-1-alpha-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1917

About EEF1A2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,488,014-63,499,083 (from NCBI)

This gene has 8 transcripts (splice variants), 180 orthologues, 18 paralogues and is associated with 5 phenotypes. Biased expression in heart (RPKM 211.2), brain (RPKM 133.2) and 3 other tissues.

Summary

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the Other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian Cancer. [provided by RefSeq, Mar 2014]

EEF1A2 Products (1)

mRNA Protein Name
NM_001958.5 NP_001949.1 elongation factor 1-alpha 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18448518 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17088255 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of lipid kinase activity IDA
IDA: Inferred from direct assay
17088255 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF1A2 Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (5 - 237)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (260 - 326)

GTP_EFTU_D3

GTP_EFTU_D3: Elongation factor Tu C-terminal domain (333 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

elongation factor 1-alpha 2

  • eukaryotic elongation factor 1 A-2

EEF1A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EEF1A2 Q05639 ABTB1 Homo sapiens Q969K4
Validated Y2H
32296183
Intra
EEF1A2 Q05639 ABTB1 Homo sapiens Q969K4
Y2H Array
25416956
Intra
EEF1A2 Q05639 ABTB1 Homo sapiens Q969K4
Anti Tag CoIP
33961781
Intra
EEF1A2 Q05639 ABTB1 Homo sapiens Q969K4
Y2H Array
31515488
Intra
EEF1A2 Q05639 ABTB1 Homo sapiens Q969K4
Validated Y2H
25416956
Intra
EEF1A2 Q05639 ABTB1 Homo sapiens Q969K4
MAPPIT
32296183
Cross
EEF1A2 Q05639 N Human SARS coronavirus P59595
Anti Tag CoIP
18448518
Intra
EEF1A2 Q05639 TTLL12 Homo sapiens Q14166
Validated Y2H
32296183
Intra
EEF1A2 Q05639 TTLL12 Homo sapiens Q14166
Anti Tag CoIP
28514442
Intra
EEF1A2 Q05639 TTLL12 Homo sapiens Q14166
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

EEF1A2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83134 Elongation Factor 1A2 Antibody (YA2879) WB, IP Human, Mouse, Rat
HY-P83134A Elongation Factor 1A2 Antibody (YA2879)(PBS only) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 33

  • DEE33

  • Epileptic Encephalopathy, Early Infantile, 33

  • Eiee33

  • Developmental And Epileptic Encephalopathy, 33

  • Early Infantile Epileptic Encephalopathy 33

  • Encephalopathy, Epileptic, Early Infantile, Type 33
Intellectual Developmental Disorder, Autosomal Dominant 38

  • Psychomotor Retardation, Epilepsy, And Language Disability Syndrome

  • MRD38

  • Prelds

  • Autosomal Dominant Non-Syndromic Intellectual Disability 38

  • Mental Retardation, Autosomal Dominant 38

  • Autosomal Dominant Intellectual Developmental Disorder 38

  • Autosomal Dominant Mental Retardation 38

  • Mental Retardation, Autosomal Dominant, Type 38
Ohtahara Syndrome
Developmental And Epileptic Encephalopathy

  • Encephalopathy, Developmental And Epileptic
Early Infantile Epileptic Encephalopathy

  • Early Infantile Epileptic Encephalopathy With Burst-Suppression

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • Eiee

  • Early Infantile Epileptic Encephalopathy With Suppression-Bursts

  • Ohtahara Syndrome

  • Encephalopathy, Epileptic, Early Infantile
Autosomal Dominant Non-Syndromic Intellectual Disability
Non-Specific Early-Onset Epileptic Encephalopathy

  • Undetermined Early-Onset Epileptic Encephalopathy

  • Non-Specific Eoee

  • Undetermined Eoee
Intrahepatic Biliary Papillomatosis

  • Intrahepatic Bile Duct Papillary Neoplasm
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome

  • ACOGS
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16050 Plitidepsin Inhibitor 99.94% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-120118 Metarrestin Inhibitor 99.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179370 EEF1A2-IN-1 / Unkown
HY-RS04175 EEF1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04176 EEF1B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19059 Eef1b2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21848 Eef1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24785 Eef1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25549 Eef1b2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EEF1A2 VGNC VGNC:72163
Bos taurus EEF1A2 VGNC VGNC:50164
Mus musculus EEF1A2 MGD MGI:1096317
Felis catus EEF1A2 VGNC VGNC:61732
Rattus norvegicus EEF1A2 RGD RGD:3781
Others EEF1A2 NCBI