1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Metarrestin

Metarrestin (Synonyms: ML246)

Cat. No.: HY-120118
Handling Instructions

Metarrestin (ML246) disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.

For research use only. We do not sell to patients.

Metarrestin Chemical Structure

Metarrestin Chemical Structure

CAS No. : 1443414-10-5

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Description

Metarrestin (ML246) disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis[1][2].

IC50 & Target

RNA polymerase (Pol) I[1][2]

Molecular Weight

474.60

Formula

C₃₁H₃₀N₄O

CAS No.

1443414-10-5

SMILES

O[[email protected]]1CC[[email protected]](N(C=NC2=C3C(C4=CC=CC=C4)=C(C5=CC=CC=C5)N2CC6=CC=CC=C6)C3=N)CC1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Metarrestin
Cat. No.:
HY-120118
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