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TTLL12 - tubulin tyrosine ligase like 12 Gene

Also Known as dJ526I14.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23170

About TTLL12

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,166,622-43,187,134 (from NCBI)

This gene has 4 transcripts (splice variants), 196 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 28.7), colon (RPKM 16.0) and 25 other tissues.

Summary

Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TTLL12 Products (1)

mRNA	Protein	Name
NM_015140.4	NP_055955.1	tubulin--tyrosine ligase-like protein 12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables H4K20me3 modified histone binding	IDA IDA: Inferred from direct assay	23251473	GOA
NOT enables histone H4K20 trimethyltransferase activity	IDA IDA: Inferred from direct assay	23251473	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23251473	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	23251473	GOA
NOT enables tubulin-tyrosine ligase activity	IDA IDA: Inferred from direct assay	23251473	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28011935	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23251473	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28011935	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTLL12 Protein Structure

TTL

0
100
200
300
400
500
600
644 a.a.

Protein Preferred Names	Protein Names
tubulin--tyrosine ligase-like protein 12	inactive tubulin--tyrosine ligase-like protein 12

TTLL12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TTLL12	Q14166	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	TTLL12	Q14166	EEF1A1	Homo sapiens	P68104	Y2H Array	32296183
Intra	TTLL12	Q14166	EEF1A1	Homo sapiens	P68104	Y2H Prey Pooling	32296183
Intra	TTLL12	Q14166	EEF1A2	Homo sapiens	Q05639	Y2H Array	32296183
Intra	TTLL12	Q14166	EEF1A2	Homo sapiens	Q05639	Y2H Prey Pooling	32296183
Intra	TTLL12	Q14166	DNAJB1	Homo sapiens	P25685	Y2H Array	32296183
Intra	TTLL12	Q14166	DNAJB1	Homo sapiens	P25685	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acute Closed-Angle Glaucoma	Acute Angle-Closure Glaucoma
Thrombocytopenia With Beta-Thalassemia, X-Linked	XLTT Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome Gata1-Related X-Linked Cytopenia X-Linked Thrombocytopenia With Beta-Thalassemia Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis
Orofaciodigital Syndrome Viii	Edwards Syndrome Trisomy 18 Complete Trisomy 18 Syndrome OFD8 Orofaciodigital Syndrome 8 Trisomy 18 Syndrome Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis E3 Trisomy Oral-Facial-Digital Syndrome Type 8 Orofaciodigital Syndrome Type 8 Ofds Viii Oral-Facial-Digital Syndrome, Type Viii Ofd Syndrome 8 Ofds 8 Oral Facial Digital Syndrome 8 Oral Facial Digital Syndrome Type 8 18 Trisomy Chromosome 18 Trisomy Trisomy 16-18 Trisomy E Trisomy E Syndrome Chromosome 18 Duplication Oral-Facial-Digital Syndrome, Edwards Type Orofaciodigital Syndrome, Edwards Type Chromosome 18, Trisomy Cleft Lip/Palate With Abnormal Thumbs And Microcephaly Trisomy 18 Chromosome Abnormal Autosomes 18
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15229	TTLL12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21967	Ttll12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28484	Ttll12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TTLL12	MGD	MGI:3039573
Canis familiaris	TTLL12	VGNC	VGNC:47975
Macaca mulatta	TTLL12	VGNC	VGNC:79757
Felis catus	TTLL12	VGNC	VGNC:66687
Bos taurus	TTLL12	VGNC	VGNC:36491
Rattus norvegicus	TTLL12	RGD	RGD:1305319
Others	TTLL12	NCBI