2. Apoptosis PI3K/Akt/mTOR
  3. Apoptosis Akt
  4. EEF1A2-IN-1

EEF1A2-IN-1 is a potent and covalen EEF1A2 inhibitor. EEF1A2-IN-1 exhibits selective antiproliferative activity against osteosarcoma (OS) cells. EEF1A2-IN-1 induces apoptosis by inhibiting EEF1A2 and downregulating the AKT signaling pathway. EEF1A2-IN-1 inhibits tumor growth in a xenograft mouse model. EEF1A2-IN-1 can be used for the research of OS.

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EEF1A2-IN-1

EEF1A2-IN-1 Chemical Structure

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EEF1A2-IN-1 Related Antibodies

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Description

EEF1A2-IN-1 is a potent and covalen EEF1A2 inhibitor. EEF1A2-IN-1 exhibits selective antiproliferative activity against osteosarcoma (OS) cells. EEF1A2-IN-1 induces apoptosis by inhibiting EEF1A2 and downregulating the AKT signaling pathway. EEF1A2-IN-1 inhibits tumor growth in a xenograft mouse model. EEF1A2-IN-1 can be used for the research of OS[1].

In Vitro

EEF1A2-IN-1 (compound 8e) (24-72 h) exhibits potent antiproliferative\ractivity against various cell lines, with IC50 values of 0.73 (143B), 2.27 (SJSA-1), 4.34 (MG63), 2.47 (MNNG/HOS), 7.25 (U2OS), 1.93 (HOS), 4.84 (A549), and 9.59 μM (BMSC), respectively[1].
EEF1A2-IN-1 (96 h-10 days) inhibits colony formation of 143B cells in an EEF1A2-dependent manner, also inhibits the proliferation of 143B cells, si-EEF1A2-2 cells, and OE-EEF1A2 143B cells with IC50 values of 0.73, 2.78, and 0.19 μM, respectively, indicating that EEF1A2 is essential for the proliferation and migration of OS 143B cells[1].
EEF1A2-IN-1 (0-3 μM, 0-24 h) effectively inhibits the migration of 143B cells[1].
EEF1A2-IN-1 (0-3 μM) effectively inhibits the invasion of 143B cells[1].
EEF1A2-IN-1 (0-3 μM) induces apoptosis in 143B cells by inhibiting its target EEF1A2, which results in the downregulation of both the Nogo-B protein and the AKT signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EEF1A2-IN-1 Related Antibodies

Cell Migration Assay [1]

Cell Line: 143B cells
Concentration: 0, 0.3, 1, 3 μM
Incubation Time: 0, 24 h
Result: Revealed a significant decrease in the percentage of intercellular wound healing distance.
Inhibited the migration of 143B cells.
In Vivo

EEFA2-IN-1 (20 mg/kg, i.p., daily for 15 days) significantly suppresses tumor growth in a 143B xenograft mouse model, without obvious toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c nude mice (3 months old) subcutaneously injected with 143B cells[1]
Dosage: 20 mg/kg
Administration: i.p., daily for 15 days
Result: Significantly suppressed OS tumor growth, with tumor growth inhibition (TGI) rates of 30.1%.
Showed no significant change in bodyweight.
Exhibited no discernible morphological changes in the heart, liver, spleen, or kidney tissues.
Molecular Weight

311.33

Formula

C18H17NO4
SMILES

C=CC(NC(C1=CC=C(C=C1)C2=CC=C(C=C2)O)C(OC)=O)=O
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Storage

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Purity & Documentation
References
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EEF1A2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EEF1A2-IN-1ApoptosisAktPKBProtein kinase BEEF1A2OsteosarcomaTarget identificationInhibitorinhibitorinhibit

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