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EEF1D - eukaryotic translation elongation factor 1 delta Gene

Also Known as EF1D; EF-1D; FP1047

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1936

About EEF1D

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,579,728-143,597,415 (from NCBI)

This gene has 54 transcripts (splice variants), 1 gene allele, 266 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 42.9), spleen (RPKM 28.8) and 25 other tissues.

Summary

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 Infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of Viral Proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

EEF1D Products (10)

mRNA	Protein	Name
NM_001130053.5	NP_001123525.3	elongation factor 1-delta isoform 1
NM_001130055.4	NP_001123527.1	elongation factor 1-delta isoform 2
NM_001130056.5	NP_001123528.1	elongation factor 1-delta isoform 4
NM_001130057.4	NP_001123529.1	elongation factor 1-delta isoform 2
NM_001195203.4	NP_001182132.1	elongation factor 1-delta isoform 5
NM_001289950.4	NP_001276879.1	elongation factor 1-delta isoform 2
NM_001317743.4	NP_001304672.1	elongation factor 1-delta isoform 4
NM_001330646.3	NP_001317575.1	elongation factor 1-delta isoform 4
NM_001960.7	NP_001951.2	elongation factor 1-delta isoform 2
NM_032378.7	NP_115754.4	elongation factor 1-delta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21597468	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21597468	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	21597468	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	21597468	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	8168075	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21597468	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8743958	GOA
colocalizes with endoplasmic reticulum	IDA IDA: Inferred from direct assay	8743958	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	21597468	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21597468	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF1D Protein Structure

EF-1_beta_acid

EF1_GNE

0
100
200
281 a.a.

Protein Preferred Names	Protein Names
elongation factor 1-delta	EF-1-delta

EEF1D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EEF1D	P29692	EEF1G	Homo sapiens	P26641-2	Validated Y2H	25416956
Intra	EEF1D	P29692	CAMSAP2	Homo sapiens	Q08AD1	Display Tech	20195357
Intra	EEF1D	P29692	ARHGAP21	Homo sapiens	Q5T5U3	Display Tech	20195357
Intra	EEF1D	P29692	TPT1	Homo sapiens	P13693	Validated Y2H	25416956
Intra	EEF1D	P29692	EEF1G	Homo sapiens	P26641	Y2H Pooling	16189514
Intra	EEF1D	P29692	EEF1G	Homo sapiens	P26641	Y2H Pooling	16169070
Intra	EEF1D	P29692	EEF1G	Homo sapiens	P26641	Anti Tag CoIP	33961781
Intra	EEF1D	P29692	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EEF1D	P29692	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EEF1D	P29692	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EEF1D	P29692	ABTB1	Homo sapiens	Q969K4	Y2H Array	31515488
Intra	EEF1D	P29692	ABTB1	Homo sapiens	Q969K4	Anti Tag CoIP	33961781
Intra	EEF1D	P29692	MAX	Homo sapiens	P61244	Pull Down	25609649
Intra	EEF1D	P29692	ERP27	Homo sapiens	Q96DN0	Y2H Array	25416956
Intra	EEF1D	P29692	ERP27	Homo sapiens	Q96DN0	Y2H Prey Pooling	25416956
Intra	EEF1D	P29692	ERP27	Homo sapiens	Q96DN0	Y2H Array	31515488
Intra	EEF1D	P29692	ERP27	Homo sapiens	Q96DN0	Validated Y2H	25416956
Intra	EEF1D	P29692	SOD1	Homo sapiens	P00441	Display Tech	20195357
Cross	EEF1D	P29692	PA	Influenza A virus	Q67020	Pull Down	21994455

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04177	EEF1D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EEF1D	VGNC	VGNC:81649
Bos taurus	EEF1D	VGNC	VGNC:53861
Rattus norvegicus	EEF1D	RGD	RGD:621174
Canis familiaris	EEF1D	VGNC	VGNC:40208
Mus musculus	EEF1D	MGD	MGI:1913906
Others	EEF1D	NCBI