BTBD3 - BTB domain containing 3 Gene

Also Known as dJ742J24.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22903

About BTBD3

Cytogenetic location: 20p12.2 Genomic coordinates (GRCh38): 20:11,890,817-11,926,595 (from NCBI)

This gene has 15 transcripts (splice variants), 217 orthologues and 11 paralogues. Ubiquitous expression in placenta (RPKM 23.1), brain (RPKM 20.6) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in cerebral cortex development and dendrite morphogenesis. Predicted to be located in nucleus. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

BTBD3 Products (13)

mRNA Protein Name
NM_001282550.3 NP_001269479.1 BTB/POZ domain-containing protein 3 isoform b
NM_001282551.2 NP_001269480.1 BTB/POZ domain-containing protein 3 isoform b
NM_001282552.3 NP_001269481.1 BTB/POZ domain-containing protein 3 isoform c
NM_001282554.2 NP_001269483.1 BTB/POZ domain-containing protein 3 isoform c
NM_001395003.1 NP_001381932.1 BTB/POZ domain-containing protein 3 isoform b
NM_001395004.1 NP_001381933.1 BTB/POZ domain-containing protein 3 isoform c
NM_001395005.1 NP_001381934.1 BTB/POZ domain-containing protein 3 isoform a
NM_001395006.1 NP_001381935.1 BTB/POZ domain-containing protein 3 isoform a
NM_001395007.1 NP_001381936.1 BTB/POZ domain-containing protein 3 isoform b
NM_001395008.1 NP_001381937.1 BTB/POZ domain-containing protein 3 isoform c
NM_001395009.1 NP_001381938.1 BTB/POZ domain-containing protein 3 isoform b
NM_014962.4 NP_055777.1 BTB/POZ domain-containing protein 3 isoform a
NM_181443.4 NP_852108.3 BTB/POZ domain-containing protein 3 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTBD3 Protein Structure

BTB

BTB: BTB/POZ domain (114 - 219)

BACK

BACK: BTB And C-terminal Kelch (235 - 300)

PHR

PHR: PHR domain (376 - 521)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
Protein Preferred Names Protein Names

BTB/POZ domain-containing protein 3

  • BTB (POZ) domain containing 3

BTBD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BTBD3 Q9Y2F9 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
BTBD3 Q9Y2F9 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
BTBD3 Q9Y2F9 BTBD6 Homo sapiens Q96KE9-2
Y2H Prey Pooling
32296183
Intra
BTBD3 Q9Y2F9 BTBD6 Homo sapiens Q96KE9-2
Y2H Array
32296183
Intra
BTBD3 Q9Y2F9 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
BTBD3 Q9Y2F9 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
BTBD3 Q9Y2F9 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
BTBD3 Q9Y2F9 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
BTBD3 Q9Y2F9 BTBD3 Homo sapiens Q9Y2F9
Y2H Array
32296183
Intra
BTBD3 Q9Y2F9 BTBD3 Homo sapiens Q9Y2F9
Y2H Prey Pooling
32296183
Intra
BTBD3 Q9Y2F9 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Intra
BTBD3 Q9Y2F9 BTBD3 Homo sapiens Q9Y2F9
Validated Y2H
32296183
Intra
BTBD3 Q9Y2F9 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichotillomania

  • TTM

  • Hair-Pulling Syndrome

  • Compulsive Hair Plucking

  • Hair Pulling Disorder
Body Dysmorphic Disorder

  • Dysmorphophobia

  • Body Dysmorphia

  • Dysmorphic Syndrome

  • Body Dysmorphic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01656 BTBD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BTBD3 VGNC VGNC:38552
Rattus norvegicus BTBD3 RGD RGD:1311623
Macaca mulatta BTBD3 VGNC VGNC:84547
Felis catus BTBD3 VGNC VGNC:60200
Bos taurus BTBD3 VGNC VGNC:26590
Mus musculus BTBD3 MGD MGI:2385155
Others BTBD3 NCBI