RNF4 - ring finger protein 4 Gene

Also Known as SLX5; SNURF; RES4-26

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6047

About RNF4

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,469,106-2,515,857 (from NCBI)

This gene has 21 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in lymph node (RPKM 20.6), testis (RPKM 19.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

RNF4 Products (3)

mRNA Protein Name
NM_001185009.3 NP_001171938.1 E3 ubiquitin-protein ligase RNF4 isoform 1
NM_001185010.3 NP_001171939.1 E3 ubiquitin-protein ligase RNF4 isoform 2
NM_002938.5 NP_002929.1 E3 ubiquitin-protein ligase RNF4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SUMO polymer binding IDA
IDA: Inferred from direct assay
35013556 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
24714598 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10713105 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
35013556 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein localization to chromatin IDA
IDA: Inferred from direct assay
35013556 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12885770 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
18408734 GOA
involved in regulation of kinetochore assembly IMP
IMP: Inferred from mutant phenotype
20212317 GOA
involved in regulation of spindle assembly IMP
IMP: Inferred from mutant phenotype
20212317 GOA
involved in response to arsenic-containing substance IDA
IDA: Inferred from direct assay
20943951 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with PML body IDA
IDA: Inferred from direct assay
20943951 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12885770 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12885770 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF4 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (131 - 177)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF4

  • E3 ubiquitin ligase RNF4

RNF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF4 P78317 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
RNF4 P78317 ZNF792 Homo sapiens Q3KQV3
Validated Y2H
32296183
Intra
RNF4 P78317 LCE1B Homo sapiens Q5T7P3
Validated Y2H
32296183
Intra
RNF4 P78317 LCE2D Homo sapiens Q5TA82
Validated Y2H
32296183
Intra
RNF4 P78317 AKAP17A Homo sapiens Q02040
Validated Y2H
32296183
Intra
RNF4 P78317 LXN Homo sapiens Q9BS40
Validated Y2H
32296183
Intra
RNF4 P78317 ZNF696 Homo sapiens Q9H7X3
Validated Y2H
32296183
Intra
RNF4 P78317 ZBTB34 Homo sapiens Q8NCN2
Validated Y2H
32296183
Intra
RNF4 P78317 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra
RNF4 P78317 CAMK2B Homo sapiens Q13554-3
Validated Y2H
32296183
Intra
RNF4 P78317 CAMK2D Homo sapiens Q13557-8
Validated Y2H
32296183
Intra
RNF4 P78317 LCE1D Homo sapiens Q5T752
Validated Y2H
32296183
Intra
RNF4 P78317 LCE1E Homo sapiens Q5T753
Validated Y2H
32296183
Intra
RNF4 P78317 LCE5A Homo sapiens Q5TCM9
Validated Y2H
32296183
Intra
RNF4 P78317 LCE1F Homo sapiens Q5T754
Validated Y2H
32296183
Intra
RNF4 P78317 LCE2C Homo sapiens Q5TA81
Validated Y2H
32296183
Intra
RNF4 P78317 LCE3B Homo sapiens Q5TA77
Validated Y2H
32296183
Intra
RNF4 P78317 RUNX1T1 Homo sapiens Q06455-2
Validated Y2H
32296183
Intra
RNF4 P78317 ZNF319 Homo sapiens Q9P2F9
Validated Y2H
32296183
Intra
RNF4 P78317 ZFP42 Homo sapiens Q96MM3
Validated Y2H
32296183
Intra
RNF4 P78317 PRR20D Homo sapiens P86480
Validated Y2H
32296183
Intra
RNF4 P78317 UBTD2 Homo sapiens Q8WUN7
Validated Y2H
32296183
Intra
RNF4 P78317 NKX3-1 Homo sapiens Q99801
Validated Y2H
32296183
Intra
RNF4 P78317 ZNF275 Homo sapiens Q9NSD4
Validated Y2H
32296183
Intra
RNF4 P78317 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
RNF4 P78317 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
Intra
RNF4 P78317 SCML2 Homo sapiens Q9UQR0
Validated Y2H
32296183
Intra
RNF4 P78317 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra
RNF4 P78317 TRPS1 Homo sapiens Q9UHF7
Anti Tag CoIP
12885770
Intra
RNF4 P78317 TRPS1 Homo sapiens Q9UHF7
Anti Bait CoIP
12885770
Intra
RNF4 P78317 DESI1 Homo sapiens Q6ICB0
Validated Y2H
32296183
Intra
RNF4 P78317 BTBD3 Homo sapiens Q9Y2F9
Validated Y2H
32296183
Intra
RNF4 P78317 DDX39B Homo sapiens Q13838
Validated Y2H
32296183
Intra
RNF4 P78317 CFL2 Homo sapiens Q9Y281
Validated Y2H
32296183
Intra
RNF4 P78317 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
RNF4 P78317 TFG Homo sapiens Q92734
Validated Y2H
32296183
Intra
RNF4 P78317 TRAF3 Homo sapiens Q13114
Validated Y2H
32296183
Intra
RNF4 P78317 TRIP13 Homo sapiens Q15645
Validated Y2H
32296183
Intra
RNF4 P78317 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
RNF4 P78317 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
Intra
RNF4 P78317 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
32296183
Intra
RNF4 P78317 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
Intra
RNF4 P78317 MYD88 Homo sapiens Q99836
Validated Y2H
32296183
Intra
RNF4 P78317 FADD Homo sapiens Q13158
Validated Y2H
32296183
Intra
RNF4 P78317 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
RNF4 P78317 ZBTB6 Homo sapiens Q15916
Validated Y2H
32296183
Intra
RNF4 P78317 PHC1 Homo sapiens P78364
Validated Y2H
32296183
Intra
RNF4 P78317 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
RNF4 P78317 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
32296183
Intra
RNF4 P78317 KLHL12 Homo sapiens Q53G59
Validated Y2H
32296183
Intra
RNF4 P78317 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
RNF4 P78317 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
RNF4 P78317 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
RNF4 P78317 ARK2N Homo sapiens Q96B23
Validated Y2H
32296183
Intra
RNF4 P78317 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Intra
RNF4 P78317 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra
RNF4 P78317 ZCCHC17 Homo sapiens Q9NP64
Validated Y2H
32296183
Intra
RNF4 P78317 DAXX Homo sapiens Q9UER7
Validated Y2H
32296183
Intra
RNF4 P78317 BCL2L1 Homo sapiens Q07817
Validated Y2H
32296183
Intra
RNF4 P78317 FAM9A Homo sapiens Q8IZU1
Validated Y2H
32296183
Intra
RNF4 P78317 FAM118A Homo sapiens Q9NWS6
Validated Y2H
32296183
Intra
RNF4 P78317 BTBD1 Homo sapiens Q9H0C5
Validated Y2H
32296183
Intra
RNF4 P78317 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RNF4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89848 RNF4 Antibody (YA9192) WB human

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143346 CCW16 98.73% Unkown
HY-184506 R4VPL3-1 / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RNF4 VGNC VGNC:34065
Mus musculus RNF4 MGD MGI:1201691
Rattus norvegicus RNF4 RGD RGD:3583
Canis familiaris RNF4 VGNC VGNC:53203
Felis catus RNF4 VGNC VGNC:64702
Macaca mulatta RNF4 VGNC VGNC:76705
Others RNF4 NCBI