SIRAL2 - SIR2 antiphage like 2 Gene

Also Known as C22orf8; FAM118A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55007

Summary

Enables identical protein binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in prostate (RPKM 10.4), lymph node (RPKM 9.2) and 23 other tissues.

SIRAL2 Products (6)

mRNA Protein Name
NM_001104595.2 NP_001098065.1 protein FAM118A isoform 1
NM_001349913.2 NP_001336842.1 protein FAM118A isoform 1
NM_001349914.2 NP_001336843.1 protein FAM118A isoform 2
NM_001349915.2 NP_001336844.1 protein FAM118A isoform 3
NM_001349916.2 NP_001336845.1 protein FAM118A isoform 4
NM_017911.4 NP_060381.2 protein FAM118A isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRAL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FAM118A Q9NWS6 ATOX1 Homo sapiens O00244
Y2H Prey Pooling
25416956
Intra
FAM118A Q9NWS6 ATOX1 Homo sapiens O00244
Y2H Array
25416956
Intra
FAM118A Q9NWS6 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
FAM118A Q9NWS6 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
FAM118A Q9NWS6 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
FAM118A Q9NWS6 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
FAM118A Q9NWS6 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
FAM118A Q9NWS6 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
FAM118A Q9NWS6 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
FAM118A Q9NWS6 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Intra
FAM118A Q9NWS6 GLRX3 Homo sapiens O76003
Validated Y2H
25416956
Intra
FAM118A Q9NWS6 AIDA Homo sapiens Q96BJ3
Validated Y2H
25416956
Intra
FAM118A Q9NWS6 AIDA Homo sapiens Q96BJ3
Y2H Array
25416956
Intra
FAM118A Q9NWS6 FAM118B Homo sapiens Q9BPY3
Validated Y2H
25416956
Intra
FAM118A Q9NWS6 FAM118B Homo sapiens Q9BPY3
Y2H Array
25416956
Intra
FAM118A Q9NWS6 FAM118B Homo sapiens Q9BPY3
Y2H Array
32296183
Intra
FAM118A Q9NWS6 FAM118B Homo sapiens Q9BPY3
Y2H Prey Pooling
25416956
Intra
FAM118A Q9NWS6 FAM118B Homo sapiens Q9BPY3
Y2H Prey Pooling
32296183
Intra
FAM118A Q9NWS6 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
FAM118A Q9NWS6 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
FAM118A Q9NWS6 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
FAM118A Q9NWS6 WDR4 Homo sapiens P57081
Y2H Array
31515488
Intra
FAM118A Q9NWS6 WDR4 Homo sapiens P57081
Validated Y2H
25416956
Intra
FAM118A Q9NWS6 MOB3C Homo sapiens Q70IA8
Validated Y2H
25416956
Intra
FAM118A Q9NWS6 MOB3C Homo sapiens Q70IA8
Y2H Array
25416956
Intra
FAM118A Q9NWS6 MOB3C Homo sapiens Q70IA8
Y2H Array
29892012
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15452 Selisistat Inhibitor 99.92% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2031 Parishin 98.92% Unkown
HY-N1926 Dihydrocoumarin Inhibitor 99.81% Unkown
HY-100585 Splitomicin Inhibitor 98.42% Unkown
HY-133859 M084 Inhibitor / Unkown
HY-150119 2'/3'-O-Acetyl-ADP-ribose sodium Substrate / Unkown
HY-184214 Antileishmanial agent-44 / Unkown
HY-W142410 2-Dodecanol / Unkown