NKX3-1 - NK3 homeobox 1 Gene

Homo sapiens

Also known as NKX3; BAPX2; NKX3A; NKX3.1

Gene ID: 4824 | Gene type: protein coding

About NKX3-1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,678,693-23,682,938 (from NCBI)

This gene has 2 transcripts (splice variants), 168 orthologues and 13 paralogues. Biased expression in prostate (RPKM 180.9) and testis (RPKM 17.6).

Summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

NKX3-1 Products(2)

mRNA	Protein	Name
NM_001256339.1	NP_001243268.1	homeobox protein Nkx-3.1 isoform 2
NM_006167.4	NP_006158.2	homeobox protein Nkx-3.1 isoform 1

NKX3-1 Protein Structure

Homeobox

0
100
200
234 a.a.

Protein Preferred Names

Protein Names

homeobox protein Nkx-3.1

NK homeobox, family 3, A

Related Diseases

Diseases

Alias

Rete Testis Neoplasm

Rete Testis Adenocarcinoma

Adenocarcinoma Of Rete Testis

Adenocarcinoma Of The Rete Testis

Salivary Gland Mucinous Adenocarcinoma

Anal Spasm

Proctospasm	Anorectal Spasm
Rectal Spasm

Cervical Adenoid Basal Carcinoma

Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate	Grade Iii Pin
Pin Iii

Prostatitis

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Atrophy Of Prostate

Adenoid Basal Cell Carcinoma

Skin Adenoid Basal Cell Carcinoma

Basal Cell Carcinoma - Adenoid

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Bladder Small Cell Carcinoma

Small Cell Bladder Cancer	Small Cell Carcinoma Of The Bladder
Poorly Differentiated Neuroendocrine Carcinoma Of The Bladder	Sccb
Small Cell Bladder Carcinoma	Small Cell Carcinoma Of The Urinary Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09333	NKX3-1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NKX3-1	VGNC	VGNC:32105
Felis catus	NKX3-1	VGNC	VGNC:78533
Mus musculus	NKX3-1	MGD	MGI:97352
Rattus norvegicus	NKX3-1	RGD	RGD:1305369
Macaca mulatta	NKX3-1	VGNC	VGNC:75355

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