NKX3-1 - NK3 homeobox 1 Gene

Also Known as NKX3; BAPX2; NKX3A; NKX3.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4824

About NKX3-1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,678,693-23,682,938 (from NCBI)

This gene has 2 transcripts (splice variants), 168 orthologues and 13 paralogues. Biased expression in prostate (RPKM 180.9) and testis (RPKM 17.6).

Summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

NKX3-1 Products (2)

mRNA Protein Name
NM_001256339.1 NP_001243268.1 homeobox protein Nkx-3.1 isoform 2
NM_006167.4 NP_006158.2 homeobox protein Nkx-3.1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20855495 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18794125 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18296735 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18974119 GOA
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: Inferred from direct assay
19266349 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
18974119 GOA
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
18794125 GOA
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
19886863 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17234752 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19780584 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19263243 GOA
enables transcription regulator inhibitor activity IDA
IDA: Inferred from direct assay
18794125 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
20395202 GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
17486276 GOA
involved in androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
19886863 GOA
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
21056661 GOA
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
18757402 GOA
involved in cellular response to steroid hormone stimulus IDA
IDA: Inferred from direct assay
19886863 GOA
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
18757402 GOA
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18757402 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18794125 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18360715 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17486276 GOA
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
17486276 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19597465 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18360715 GOA
involved in positive regulation of androgen secretion IDA
IDA: Inferred from direct assay
19886863 GOA
involved in positive regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
20599703 GOA
involved in positive regulation of cell division IMP
IMP: Inferred from mutant phenotype
20855495 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18360715 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
20599703 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
17486276 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20716579 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
17486276 GOA
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20855495 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
20395202 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
20395202 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19797053 GOA
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
20395202 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18757402 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
20395202 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKX3-1 Protein Structure

Homeobox

Homeobox: Homeobox domain (125 - 181)

  • 0
  • 100
  • 200
  • 234 a.a.
Protein Preferred Names Protein Names

homeobox protein Nkx-3.1

  • NK homeobox, family 3, A

NKX3-1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NKX3-1 Q99801 CD200R1L Homo sapiens Q6Q8B3
Y2H Prey Pooling
32296183
Intra
NKX3-1 Q99801 CD200R1L Homo sapiens Q6Q8B3
Y2H Array
32296183
Intra
NKX3-1 Q99801 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
NKX3-1 Q99801 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
NKX3-1 Q99801 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
Intra
NKX3-1 Q99801 ZNF417 Homo sapiens Q8TAU3
Y2H Array
32296183
Intra
NKX3-1 Q99801 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
32296183
Intra
NKX3-1 Q99801 TOP1 Homo sapiens P11387
Pull Down
17234752
Intra
NKX3-1 Q99801 TOP1 Homo sapiens P11387
Confocal
17234752
Cross: Cross-species interaction Intra: Intraspecies interaction

NKX3-1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82572 NKX3.1 Antibody (YA2317) WB, IHC-P Human
HY-P84755 NKX3.1 Antibody (YA4452) WB, IHC-P, FC, ELISA Human
HY-P84755A NKX3.1 Antibody (YA4452)(PBS only) WB, IHC-P, FC, ELISA Human
HY-P85298 NKX3.1 Antibody (YA4990) WB, IHC-P, IHC-F, IF-Tissue Human

Related Diseases

Diseases Alias
Rete Testis Neoplasm
Rete Testis Adenocarcinoma

  • Adenocarcinoma Of Rete Testis

  • Adenocarcinoma Of The Rete Testis
Salivary Gland Mucinous Adenocarcinoma
Anal Spasm

  • Proctospasm

  • Anorectal Spasm

  • Rectal Spasm
Cervical Adenoid Basal Carcinoma
Prostate Carcinoma In Situ

  • Carcinoma In Situ Of Prostate

  • Grade Iii Pin

  • Pin Iii
Prostatitis
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Prostatic Acinar Adenocarcinoma

  • Acinar Prostate Adenocarcinoma
Atrophy Of Prostate
Adenoid Basal Cell Carcinoma

  • Skin Adenoid Basal Cell Carcinoma

  • Basal Cell Carcinoma - Adenoid
Suppression Of Tumorigenicity 12

  • Prostate Adenocarcinoma

  • Adenocarcinoma Of Prostate

  • ST12

  • Prostate Adenocarcinoma 1

  • Pac1
Bladder Small Cell Carcinoma

  • Small Cell Bladder Cancer

  • Small Cell Carcinoma Of The Bladder

  • Poorly Differentiated Neuroendocrine Carcinoma Of The Bladder

  • Sccb

  • Small Cell Bladder Carcinoma

  • Small Cell Carcinoma Of The Urinary Bladder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09333 NKX3-1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NKX3-1 VGNC VGNC:32105
Felis catus NKX3-1 VGNC VGNC:78533
Mus musculus NKX3-1 MGD MGI:97352
Rattus norvegicus NKX3-1 RGD RGD:1305369
Macaca mulatta NKX3-1 VGNC VGNC:75355
Others NKX3-1 NCBI