TRAF3 - TNF receptor associated factor 3 Gene

Also Known as CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp; RNF118

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7187

About TRAF3

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:102,777,449-102,911,500 (from NCBI)

This gene has 13 transcripts (splice variants), 135 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 5.0), appendix (RPKM 4.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the TNF Receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF Receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent Infection membrane protein-1 (LMP1) can interact with this and several Other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of Antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

TRAF3 Products (6)

mRNA	Protein	Name
NM_001199427.2	NP_001186356.1	TNF receptor-associated factor 3 isoform 3
NM_001385142.1	NP_001372071.1	TNF receptor-associated factor 3 isoform 4
NM_001385143.1	NP_001372072.1	TNF receptor-associated factor 3 isoform 5
NM_003300.4	NP_003291.2	TNF receptor-associated factor 3 isoform 1
NM_145725.3	NP_663777.1	TNF receptor-associated factor 3 isoform 1
NM_145726.3	NP_663778.1	TNF receptor-associated factor 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7527023	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	23871208	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables tumor necrosis factor receptor binding	IPI IPI: Inferred from physical interaction	11728344	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19898473	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19898473	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	20185819	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	19898473	GOA
involved in regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	20185819	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	18222170	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20185819	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in endosome	IDA IDA: Inferred from direct assay	18222170	GOA
is active in endosome membrane	IDA IDA: Inferred from direct assay	18222170	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	19898473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF3 Protein Structure

zf-TRAF

MATH

0
100
200
300
400
500
568 a.a.

Protein Preferred Names	Protein Names
TNF receptor-associated factor 3	CD40 associated protein 1

TRAF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRAF3	Q13114	CCDC184	Homo sapiens	Q52MB2	Validated Y2H	32296183
Intra	TRAF3	Q13114	CCDC184	Homo sapiens	Q52MB2	Y2H Array	32296183
Intra	TRAF3	Q13114	CCDC184	Homo sapiens	Q52MB2	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	TRAF3	Q13114	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	TRAF3	Q13114	PDZD4	Homo sapiens	Q17RL8	Validated Y2H	32296183
Intra	TRAF3	Q13114	CCDC13	Homo sapiens	Q8IYE1	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
Intra	TRAF3	Q13114	CCDC13	Homo sapiens	Q8IYE1	Y2H Array	32296183
Intra	TRAF3	Q13114	ASCC1	Homo sapiens	Q8N9N2-2	Validated Y2H	32296183
Intra	TRAF3	Q13114	IP6K3	Homo sapiens	Q96PC2	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	IP6K3	Homo sapiens	Q96PC2	Validated Y2H	32296183
Intra	TRAF3	Q13114	IP6K3	Homo sapiens	Q96PC2	Y2H Array	32296183
Intra	TRAF3	Q13114	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
Intra	TRAF3	Q13114	BIVM	Homo sapiens	Q86UB2	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	BIVM	Homo sapiens	Q86UB2	Validated Y2H	32296183
Intra	TRAF3	Q13114	BIVM	Homo sapiens	Q86UB2	Y2H Array	32296183
Intra	TRAF3	Q13114	GMEB1	Homo sapiens	Q9Y692	Y2H	32514408
Intra	TRAF3	Q13114	GMEB1	Homo sapiens	Q9Y692	Pull Down	32514408
Intra	TRAF3	Q13114	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	TRAF3	Q13114	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	ZBTB49	Homo sapiens	Q6ZSB9	Validated Y2H	32296183
Intra	TRAF3	Q13114	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	TRAF3	Q13114	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	TRAF3	Q13114	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	TANK	Homo sapiens	Q92844	Anti Tag CoIP	34084167
Intra	TRAF3	Q13114	TANK	Homo sapiens	Q92844	TAP	14743216
Intra	TRAF3	Q13114	TANK	Homo sapiens	Q92844	X-Ray Diffraction	12005438
Intra	TRAF3	Q13114	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	34084167
Intra	TRAF3	Q13114	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	27135603
Intra	TRAF3	Q13114	SNAP29	Homo sapiens	O95721	Y2H Array	32296183
Intra	TRAF3	Q13114	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	32296183
Intra	TRAF3	Q13114	MAP3K14	Homo sapiens	Q99558	TAP	14743216
Intra	TRAF3	Q13114	MAP3K14	Homo sapiens	Q99558	Validated Y2H	32296183
Intra	TRAF3	Q13114	RIPK1	Homo sapiens	Q13546	Validated Y2H	32296183
Intra	TRAF3	Q13114	RIPK1	Homo sapiens	Q13546	Y2H	8612133
Intra	TRAF3	Q13114	RIPK2	Homo sapiens	O43353	Anti Bait CoIP	23333941
Intra	TRAF3	Q13114	BRAF	Homo sapiens	P15056	Anti Bait CoIP	23153539
Intra	TRAF3	Q13114	CD40	Homo sapiens	P25942	Y2H	7527023
Intra	TRAF3	Q13114	CD40	Homo sapiens	P25942	Pull Down	7527023
Intra	TRAF3	Q13114	EDA2R	Homo sapiens	Q9HAV5	CoIP	15280356
Cross	TRAF3	Q13114	Zbp1	Mus musculus	A2APF7	Anti Tag CoIP	21903422
Intra	TRAF3	Q13114	ZSCAN4	Homo sapiens	Q8NAM6	Validated Y2H	32296183
Intra	TRAF3	Q13114	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	TRAF3	Q13114	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	TRAF3	Q13114	C10orf62	Homo sapiens	Q5T681	Validated Y2H	32296183
Intra	TRAF3	Q13114	IFT25	Homo sapiens	Q9Y547	Validated Y2H	32296183
Intra	TRAF3	Q13114	TRAF3IP1	Homo sapiens	Q8TDR0	Anti Bait CoIP	10791955
Intra	TRAF3	Q13114	TRAF3IP1	Homo sapiens	Q8TDR0	Pull Down	10791955
Intra	TRAF3	Q13114	GMEB2	Homo sapiens	Q9UKD1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TRAF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87118	TRAF3 Antibody (YA6811)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Encephalopathy, Acute, Infection-Induced 5	Herpes Simplex Encephalitis, Susceptibility To, 3 IIAE5 Herpes Simplex Encephalitis 3 Encephalopathy, Acute, Infection-Induced , Susceptibility To, 5 Encephalopathy, Acute, Infection-Induced, 5, Herpes-Specific Encephalopathy, Acute, Infection-Induced, 5 Hse3 Infection-Induced Acute Encephalopathy 5
Herpes Simplex Encephalitis	Hse Hsv Encephalitis Hsve Herpes Simplex Meningo-Encephalitis Herpes Simplex Neuroinvasion Herpes Simplex Virus Encephalitis Herpetic Encephalitis Herpes Encephalitis Herpes Simplex Virus 1 Encephalitis
Multisystem Inflammatory Syndrome In Children	Mis-C Multisystem Inflammatory Disorder In Children And Adolescents Paediatric Inflammatory Multisystemic Syndrome Mic
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Anus Basaloid Carcinoma	Basaloid Carcinoma Of The Anus Anal Basaloid Carcinoma
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Brooke-Spiegler Syndrome	Cyld Cutaneous Syndrome Spiegler-Brooke Syndrome Familial Cylindromatosis BRSS Bss Sbs Multiple Familial Trichoepithelioma Ancell-Spiegler Cylindromas Familial Multiple Trichoepithelioma Trichoepithelioma Fc Mft Multiple Familial Trichoepitheliomas Ccs Turban Tumor Syndrome Schilbach-Rott Syndrome Eccrine Dermal Cylindroma Familial Multiple Trichoepitheliomata
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-185123	Pig TRIM56 mRNA		/	Unkown
HY-RS14969	TRAF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14970	TRAF3IP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14971	TRAF3IP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14972	TRAF3IP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17996	Traf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22078	Traf3ip2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24468	Traf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28597	Traf3ip2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRAF3	MGD	MGI:108041
Bos taurus	TRAF3	VGNC	VGNC:36272
Felis catus	TRAF3	VGNC	VGNC:66496
Macaca mulatta	TRAF3	VGNC	VGNC:78642
Canis familiaris	TRAF3	VGNC	VGNC:47764
Rattus norvegicus	TRAF3	RGD	RGD:1304633
Others	TRAF3	NCBI