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GMEB2 - glucocorticoid modulatory element binding protein 2 Gene

Also Known as PIF79; GMEB-2; P79PIF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26205

About GMEB2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,587,605-63,627,101 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 6.7), testis (RPKM 6.1) and 25 other tissues.

Summary

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the Glucocorticoid Receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

GMEB2 Products (1)

mRNA	Protein	Name
NM_012384.5	NP_036516.1	glucocorticoid modulatory element-binding protein 2

GMEB2 Protein Structure

SAND

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400
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530 a.a.

Protein Preferred Names	Protein Names
glucocorticoid modulatory element-binding protein 2	DNA-binding protein p79PIF

GMEB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GMEB2	Q9UKD1	MXRA8	Homo sapiens	Q9BRK3	Y2H Array	32296183
Intra	GMEB2	Q9UKD1	MXRA8	Homo sapiens	Q9BRK3	Y2H Prey Pooling	32296183
Intra	GMEB2	Q9UKD1	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	GMEB2	Q9UKD1	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	GMEB2	Q9UKD1	TTF2	Homo sapiens	Q9UNY4-2	Validated Y2H	32296183
Intra	GMEB2	Q9UKD1	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	GMEB2	Q9UKD1	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	GMEB2	Q9UKD1	TRAF3	Homo sapiens	Q13114	Y2H Array	32296183
Intra	GMEB2	Q9UKD1	TRAF3	Homo sapiens	Q13114	Y2H Prey Pooling	32296183
Intra	GMEB2	Q9UKD1	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
Intra	GMEB2	Q9UKD1	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
Intra	GMEB2	Q9UKD1	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	GMEB2	Q9UKD1	GMEB2	Homo sapiens	Q9UKD1	Y2H Prey Pooling	32296183
Intra	GMEB2	Q9UKD1	GMEB2	Homo sapiens	Q9UKD1	Validated Y2H	32296183
Intra	GMEB2	Q9UKD1	GMEB2	Homo sapiens	Q9UKD1	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma
Vulvovaginitis	Vulvo-Vaginitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05517	GMEB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21584	Gmeb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28102	Gmeb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GMEB2	VGNC	VGNC:84914
Rattus norvegicus	GMEB2	RGD	RGD:620481
Mus musculus	GMEB2	MGD	MGI:2652836
Felis catus	GMEB2	VGNC	VGNC:62606
Bos taurus	GMEB2	VGNC	VGNC:29433
Canis familiaris	GMEB2	VGNC	VGNC:41287
Others	GMEB2	NCBI