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TANK - TRAF family member associated NFKB activator Gene

Also Known as ITRAF; TRAF2; I-TRAF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10010

About TANK

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,136,963-161,236,230 (from NCBI)

This gene has 23 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in appendix (RPKM 16.5), lymph node (RPKM 16.3) and 25 other tissues.

Summary

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

TANK Products (3)

mRNA	Protein	Name
NM_001199135.3	NP_001186064.1	TRAF family member-associated NF-kappa-B activator isoform a
NM_004180.3	NP_004171.2	TRAF family member-associated NF-kappa-B activator isoform a
NM_133484.2	NP_597841.1	TRAF family member-associated NF-kappa-B activator isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	25861989	GOA
enables deubiquitinase activator activity	IMP IMP: Inferred from mutant phenotype	25861989	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	21931631	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12005438	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11279055	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	25861989	GOA
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	25861989	GOA
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	25861989	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	25861989	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25861989	GOA
involved in positive regulation of protein deubiquitination	IMP IMP: Inferred from mutant phenotype	25861989	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	21931631	GOA
involved in positive regulation of ubiquitin-specific protease activity	IMP IMP: Inferred from mutant phenotype	25861989	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	21931631	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25861989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TANK Protein Structure

TBD

0
100
200
300
400
425 a.a.

Protein Preferred Names	Protein Names
TRAF family member-associated NF-kappa-B activator	TRAF-interacting protein

TANK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TANK	Q92844	TP53BP2	Homo sapiens	Q13625-3	Y2H Prey Pooling	25416956
Intra	TANK	Q92844	TP53BP2	Homo sapiens	Q13625-3	Validated Y2H	25416956
Intra	TANK	Q92844	TSC1	Homo sapiens	Q92574	Y2H Pooling	21653829
Intra	TANK	Q92844	TSC1	Homo sapiens	Q92574	Anti Tag CoIP	21653829
Intra	TANK	Q92844	SRSF11	Homo sapiens	Q05519	Validated Y2H	25416956
Intra	TANK	Q92844	IKBKE	Homo sapiens	Q14164	Crosslink	21212807
Intra	TANK	Q92844	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	17568778
Intra	TANK	Q92844	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	33961781
Intra	TANK	Q92844	TRAF2	Homo sapiens	Q12933	ViroTrap	30561431
Intra	TANK	Q92844	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	21903422
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Lumier	21931555
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	TAP	14743216
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Pull Down	18307994
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	ViroTrap	30561431
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Y2H	21988832
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	33961781
Intra	TANK	Q92844	TRAF3	Homo sapiens	Q13114	ViroTrap	30561431
Intra	TANK	Q92844	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	21903422
Intra	TANK	Q92844	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	33961781
Intra	TANK	Q92844	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	TANK	Q92844	SUMO2	Homo sapiens	P61956	Pull Down	21212807
Intra	TANK	Q92844	PLK1	Homo sapiens	P53350	Anti Tag CoIP	33961781
Intra	TANK	Q92844	PLK1	Homo sapiens	P53350	Y2H	21988832
Intra	TANK	Q92844	APBA3	Homo sapiens	O96018	Anti Tag CoIP	21903422
Intra	TANK	Q92844	CEP63	Homo sapiens	Q96MT8	Y2H Prey Pooling	25416956
Intra	TANK	Q92844	CEP63	Homo sapiens	Q96MT8	Y2H Array	25416956
Intra	TANK	Q92844	IKBKG	Homo sapiens	Q9Y6K9	ViroTrap	30561431
Intra	TANK	Q92844	IKBKG	Homo sapiens	Q9Y6K9	Y2H	21988832
Cross	TANK	Q92844	OPG029	vaccinia virus	P17362	Anti Tag CoIP	21931555
Cross	TANK	Q92844	NS	Influenza A virus	P03495	Y2H	24008843
Cross	TANK	Q92844	NS	Influenza A virus	P03495	Pull Down	24008843

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nipah Virus Encephalitis	Equine Morbillivirus
Immunodeficiency 33	IMD33 X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency X-Linked Msmd Due To Ikbkg Deficiency X-Linked Msmd Due To Nemo Deficiency Invasive Pneumococcal Disease, Recurrent Isolated, 2 Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly Ipd2, Formerly Nf-Kappa B Essential Modulator Deficiency Familial X-Linked 1 Atypical Mycobacteriosis Nemo Deficiency Syndrome Amcbx1 Familial, X-Linked, Atypical Mycobacteriosis 1 Ipd2 Recurrent Isolated Invasive Pneumococcal Disease 2 X-Linked Disseminated Atypical Mycobacterial Infection Type 1 X-Linked Immunodeficiency 33, Mycobacteriosis X-Linked Susceptibility To Mycobacterial Disease Type 1 Invasive Pneumococcal Disease, Recurrent Isolated, Type 2 Atypical Mycobacteriosis, Familial, X-Linked 1
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4	FTDALS4 Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-4 Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111941	GSK8612	Inhibitor	99.56%	Unkown
HY-152237	TBK1-IN-1	Inhibitor	99.63%	Unkown
HY-112557	PROTAC TBK1 degrader-2	Inhibitor	98.20%	Unkown
HY-117700	TNKS-IN-2	Inhibitor	/	Unkown
HY-183098	UNC8209		/	Unkown
HY-RS14197	TANK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18372	Tank Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24851	Tank Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W714178	Aziprotryne		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TANK	RGD	RGD:628859
Felis catus	TANK	VGNC	VGNC:65952
Mus musculus	TANK	MGD	MGI:107676
Bos taurus	TANK	VGNC	VGNC:35594
Macaca mulatta	TANK	VGNC	VGNC:78097
Canis familiaris	TANK	VGNC	VGNC:47101
Others	TANK	NCBI