TANK - TRAF family member associated NFKB activator Gene

Homo sapiens

Also known as ITRAF; TRAF2; I-TRAF

Gene ID: 10010 | Gene type: protein coding

About TANK

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,136,963-161,236,230 (from NCBI)

This gene has 23 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in appendix (RPKM 16.5), lymph node (RPKM 16.3) and 25 other tissues.

Summary

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

TANK Products(3)

mRNA	Protein	Name
NM_001199135.3	NP_001186064.1	TRAF family member-associated NF-kappa-B activator isoform a
NM_004180.3	NP_004171.2	TRAF family member-associated NF-kappa-B activator isoform a
NM_133484.2	NP_597841.1	TRAF family member-associated NF-kappa-B activator isoform b

TANK Protein Structure

TBD

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

TRAF family member-associated NF-kappa-B activator

TRAF-interacting protein

Related Diseases

Diseases

Alias

Nipah Virus Encephalitis

Equine Morbillivirus

Immunodeficiency 33

IMD33	X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency
X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency	X-Linked Msmd Due To Ikbkg Deficiency
X-Linked Msmd Due To Nemo Deficiency	Invasive Pneumococcal Disease, Recurrent Isolated, 2
Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly	Ipd2, Formerly
Nf-Kappa B Essential Modulator Deficiency	Familial X-Linked 1 Atypical Mycobacteriosis
Nemo Deficiency Syndrome	Amcbx1
Familial, X-Linked, Atypical Mycobacteriosis 1	Ipd2
Recurrent Isolated Invasive Pneumococcal Disease 2	X-Linked Disseminated Atypical Mycobacterial Infection Type 1
X-Linked Immunodeficiency 33, Mycobacteriosis	X-Linked Susceptibility To Mycobacterial Disease Type 1
Invasive Pneumococcal Disease, Recurrent Isolated, Type 2	Atypical Mycobacteriosis, Familial, X-Linked 1

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4

FTDALS4	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-4
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111941	GSK8612	Inhibitor	99.33%	Unkown
HY-152237	TBK1-IN-1	Inhibitor	99.91%	Unkown
HY-112557	PROTAC TBK1 degrader-2	Inhibitor	98.20%	Unkown
HY-117700	TNKS-IN-2	Inhibitor	/	Unkown
HY-RS14197	TANK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TANK	RGD	RGD:628859
Felis catus	TANK	VGNC	VGNC:65952
Mus musculus	TANK	MGD	MGI:107676
Bos taurus	TANK	VGNC	VGNC:35594
Macaca mulatta	TANK	VGNC	VGNC:78097
Canis familiaris	TANK	VGNC	VGNC:47101
Others	TANK	NCBI

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