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Cat. No.: HY-117700

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TNKS-IN-2

TNKS-IN-2 (compound 40) is a potent and selective tankyrase (TNKS) inhibitor with pIC₅₀ values of 8.1, 7.0 for TANKS and Wnt, respectively.

For research use only. We do not sell to patients.

CAS No.: 1584646-59-2
Formula: C₂₄H₂₂N₁₀O₂
Molecular Weight:482.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TNKS-IN-2 Chemical Structure

CAS No.: 1584646-59-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TNKS-IN-2 (compound 40) is a potent and selective tankyrase (TNKS) inhibitor with pIC₅₀ values of 8.1, 7.0 for TANKS and Wnt, respectively^[1].

IC₅₀ & Target^[1]

TNKS

8.1 (pIC₅₀)

Wnt

7.0 (pIC₅₀)

All Wnt Isoforms :

All PARP Isoforms :

Chemical Information

CAS No. 1584646-59-2
Molecular Weight 482.50
Formula C₂₄H₂₂N₁₀O₂
SMILES

O=C(N1CCN(CC1)C(C2=CC=C(C=C2)NC3=NC4=C(C=CC=C4)N5C3=NN=N5)=O)C6=NN(C=C6)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thomson DW, et al. Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. J Med Chem. 2017 Jul 13;60(13):5455-5471. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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TNKS-IN-2

All Wnt Isoforms

All PARP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TNKS-IN-2 Related Classifications

HY-117700 Related Classifications