SRSF11 - serine and arginine rich splicing factor 11 Gene

Also Known as p54; NET2; SFRS11; dJ677H15.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9295

About SRSF11

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:70,205,696-70,253,052 (from NCBI)

This gene has 18 transcripts (splice variants), 280 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 46.2), skin (RPKM 32.0) and 25 other tissues.

Summary

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

SRSF11 Products (21)

mRNA Protein Name
NM_001190987.3 NP_001177916.1 serine/arginine-rich splicing factor 11 isoform 2
NM_001350605.2 NP_001337534.1 serine/arginine-rich splicing factor 11 isoform 1
NM_001350606.2 NP_001337535.1 serine/arginine-rich splicing factor 11 isoform 1
NM_001350607.2 NP_001337536.1 serine/arginine-rich splicing factor 11 isoform 2
NM_001350608.2 NP_001337537.1 serine/arginine-rich splicing factor 11 isoform 3
NM_001350609.2 NP_001337538.1 serine/arginine-rich splicing factor 11 isoform 4
NM_001350610.2 NP_001337539.1 serine/arginine-rich splicing factor 11 isoform 5
NM_001350611.2 NP_001337540.1 serine/arginine-rich splicing factor 11 isoform 6
NM_001350612.2 NP_001337541.1 serine/arginine-rich splicing factor 11 isoform 7
NM_001350613.2 NP_001337542.1 serine/arginine-rich splicing factor 11 isoform 7
NM_001350614.2 NP_001337543.1 serine/arginine-rich splicing factor 11 isoform 8
NM_001350615.2 NP_001337544.1 serine/arginine-rich splicing factor 11 isoform 8
NM_001350616.2 NP_001337545.1 serine/arginine-rich splicing factor 11 isoform 8
NM_001394402.1 NP_001381331.1 serine/arginine-rich splicing factor 11 isoform 9
NM_001394403.1 NP_001381332.1 serine/arginine-rich splicing factor 11 isoform 9
NM_001394404.1 NP_001381333.1 serine/arginine-rich splicing factor 11 isoform 3
NM_001394405.1 NP_001381334.1 serine/arginine-rich splicing factor 11 isoform 4
NM_001394406.1 NP_001381335.1 serine/arginine-rich splicing factor 11 isoform 1
NM_001394407.1 NP_001381336.1 serine/arginine-rich splicing factor 11 isoform 2
NM_001394408.1 NP_001381337.1 serine/arginine-rich splicing factor 11 isoform 2
NM_004768.5 NP_004759.1 serine/arginine-rich splicing factor 11 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF11 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (37 - 101)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 11

  • SR splicing factor 11

SRSF11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRSF11 Q05519 g4xuv3_human Homo sapiens G4XUV3
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 ARL6IP4 Homo sapiens Q66PJ3-3
Validated Y2H
25416956
Intra
SRSF11 Q05519 ARL6IP4 Homo sapiens Q66PJ3-3
Y2H Array
25416956
Intra
SRSF11 Q05519 SREK1 Homo sapiens Q8WXA9
Y2H Array
25416956
Intra
SRSF11 Q05519 SREK1 Homo sapiens Q8WXA9
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 PUF60 Homo sapiens Q9UHX1
Y2H Array
25416956
Intra
SRSF11 Q05519 PUF60 Homo sapiens Q9UHX1
Anti Tag CoIP
33961781
Intra
SRSF11 Q05519 PUF60 Homo sapiens Q9UHX1
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 PUF60 Homo sapiens Q9UHX1
Validated Y2H
25416956
Intra
SRSF11 Q05519 TANK Homo sapiens Q92844
Y2H Array
25416956
Intra
SRSF11 Q05519 TANK Homo sapiens Q92844
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 RBM39 Homo sapiens Q14498
Y2H Array
25416956
Intra
SRSF11 Q05519 ARL6IP4 Homo sapiens Q66PJ3-4
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 GATC Homo sapiens O43716
Validated Y2H
25416956
Intra
SRSF11 Q05519 GATC Homo sapiens O43716
Y2H Array
25416956
Intra
SRSF11 Q05519 GATC Homo sapiens O43716
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
SRSF11 Q05519 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 HYI Homo sapiens Q5T013
Y2H Array
25416956
Intra
SRSF11 Q05519 HYI Homo sapiens Q5T013
Y2H Prey Pooling
25416956
Intra
SRSF11 Q05519 ETS1 Homo sapiens P14921
Y2H Array
21988832
Intra
SRSF11 Q05519 ETS1 Homo sapiens P14921
Display Tech
20195357
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13792 SRSF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SRSF11 VGNC VGNC:35299
Rattus norvegicus SRSF11 RGD RGD:1559953
Macaca mulatta SRSF11 VGNC VGNC:77818
Felis catus SRSF11 VGNC VGNC:65694
Canis familiaris SRSF11 VGNC VGNC:46817
Mus musculus SRSF11 MGD MGI:1916457
Others SRSF11 NCBI