HYI - hydroxypyruvate isomerase (putative) Gene

Also Known as HT036

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81888

About HYI

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,450,607-43,453,931 (from NCBI)

This gene has 12 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in fat (RPKM 17.6), duodenum (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

HYI Products (4)

mRNA Protein Name
NM_001190880.3 NP_001177809.1 putative hydroxypyruvate isomerase isoform 3
NM_001243526.2 NP_001230455.1 putative hydroxypyruvate isomerase isoform 4
NM_001330526.2 NP_001317455.1 putative hydroxypyruvate isomerase isoform 5
NM_031207.6 NP_112484.3 putative hydroxypyruvate isomerase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HYI Protein Structure

AP_endonuc_2

AP_endonuc_2: Xylose isomerase-like TIM barrel (25 - 226)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

putative hydroxypyruvate isomerase

  • endothelial cell apoptosis protein E-CE1

HYI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HYI Q5T013 SRSF11 Homo sapiens Q05519
Validated Y2H
25416956
Intra
HYI Q5T013 TEX11 Homo sapiens Q8IYF3
Y2H Prey Pooling
25416956
Intra
HYI Q5T013 DDAH2 Homo sapiens O95865
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wrinkly Skin Syndrome

  • WSS

  • Wrinkled Skin Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-NP0196 Mouse immunoglobulin G 96% Unkown
HY-66047 2,4-Dihydroxypyrimidine-5-carboxylic Acid 99.90% Unkown
HY-N12931F Maackia amurensis Lectin (MAA/MAL II)-Biotinylated / Unkown
HY-I1111S Fmoc-L-Val-OH-d8 99.64% Unkown
HY-I0210S 4-Iodoaniline-13C6 99.17% Unkown
HY-W015205 5-Bromocytosine 99.77% Unkown
HY-W249514 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester-d3 ≥98.0% Unkown
HY-I0736S Isonicotinic acid-d4 98.12% Unkown
HY-175875 HRZ-01-082-5 Degrader / Unkown
HY-I0447S 4-Aminosalicylic acid-d6 / Unkown
HY-I1029S L-Homophenylalanine-d4 / Unkown
HY-I1029S1 L-Homophenylalanine-d2 / Unkown
HY-I1029S2 L-Homophenylalanine-d2-1 / Unkown
HY-I1111S1 Fmoc-L-Val-OH-1-13C / Unkown
HY-I1111S3 Fmoc-L-Val-OH-13C5 / Unkown
HY-I1111S4 Fmoc-L-Val-OH-15N / Unkown
HY-RS06500 HYI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W701408 rac-Rotigotine-d3 methyl ether / Unkown
HY-W704197 N-tert-Butylcarbamoyl-L-tert-leucine-d9 / Unkown
HY-W713450 N-Acetyl-4-aminosalicylic acid-d3 / Unkown
HY-W751140 (2-Aminothiazole-4-yl)acetic acid-13C,15N2 / Unkown
HY-W767978 1-(4,4-Dimethylthiochroman-6-yl)ethanone-d8 / Unkown
HY-W768262 D-(+)-Glucono-1,5-lactone-13C6 / Unkown
HY-185199 Nornarwedine / Unkown
HY-I0348R Ticagrelor impurity 20 (Standard) / Unkown
HY-I1111S2 Fmoc-L-Val-OH-13C5,15N 98% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HYI RGD RGD:1561416
Bos taurus HYI VGNC VGNC:55238
Felis catus HYI VGNC VGNC:80239
Mus musculus HYI MGD MGI:1915430
Canis familiaris HYI VGNC VGNC:54559
Macaca mulatta HYI VGNC VGNC:99973
Others HYI NCBI