TEX11 - testis expressed 11 Gene

Also Known as TGC1; ZIP4; MZIP4; Spo22; TSGA3; ZIP4H; SPGFX2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56159

About TEX11

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,511,227-70,908,711 (from NCBI)

This gene has 4 transcripts (splice variants), 145 orthologues and is associated with 2 phenotypes. Biased expression in pancreas (RPKM 5.2), testis (RPKM 5.1) and 1 other tissue.

Summary

This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TEX11 Products (2)

mRNA	Protein	Name
NM_001003811.2	NP_001003811.1	testis-expressed protein 11 isoform 1
NM_031276.3	NP_112566.2	testis-expressed protein 11 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEX11 Protein Structure

SPO22

0
200
400
600
800
940 a.a.

Protein Preferred Names	Protein Names
testis-expressed protein 11	ZIP4 homolog

TEX11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TEX11	Q8IYF3	CCDC198	Homo sapiens	Q9NVL8	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	CCDC198	Homo sapiens	Q9NVL8	Y2H Array	25416956
Intra	TEX11	Q8IYF3	C6orf226	Homo sapiens	Q5I0X4	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	TEX11	Q8IYF3	TSC22D4	Homo sapiens	Q8IV54	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	TSC22D4	Homo sapiens	Q8IV54	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	REXO1L1P	Homo sapiens	Q8IX06	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	REXO1L1P	Homo sapiens	Q8IX06	Y2H Array	25416956
Intra	TEX11	Q8IYF3	RIBC1	Homo sapiens	Q8N443	Y2H Array	25416956
Intra	TEX11	Q8IYF3	RIBC1	Homo sapiens	Q8N443	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	COL20A1	Homo sapiens	Q9P218-2	Y2H Array	25416956
Intra	TEX11	Q8IYF3	COL20A1	Homo sapiens	Q9P218-2	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	COL20A1	Homo sapiens	Q9P218-2	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	MYEF2	Homo sapiens	Q9P2K5-2	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	MYEF2	Homo sapiens	Q9P2K5-2	Y2H Array	25416956
Intra	TEX11	Q8IYF3	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	CXCL14	Homo sapiens	O95715	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	CXCL14	Homo sapiens	O95715	Y2H Array	25416956
Intra	TEX11	Q8IYF3	CDKN1A	Homo sapiens	P38936	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	SNW1	Homo sapiens	Q13573	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	SEPTIN1	Homo sapiens	Q8WYJ6	Y2H Array	25416956
Intra	TEX11	Q8IYF3	SEPTIN1	Homo sapiens	Q8WYJ6	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	MAPK9	Homo sapiens	P45984	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	STMN2	Homo sapiens	Q93045	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	BEX1	Homo sapiens	Q9HBH7	Y2H Array	25416956
Intra	TEX11	Q8IYF3	BEX1	Homo sapiens	Q9HBH7	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	DUSP21	Homo sapiens	Q9H596	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	DUSP21	Homo sapiens	Q9H596	Y2H Array	25416956
Intra	TEX11	Q8IYF3	POM121	Homo sapiens	Q96HA1	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	POM121	Homo sapiens	Q96HA1	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	TEX11	Q8IYF3	BORCS8	Homo sapiens	Q96FH0	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	BORCS8	Homo sapiens	Q96FH0	Y2H Array	25416956
Intra	TEX11	Q8IYF3	HYI	Homo sapiens	Q5T013	Y2H Array	25416956
Intra	TEX11	Q8IYF3	HYI	Homo sapiens	Q5T013	Y2H Pooling	16189514
Intra	TEX11	Q8IYF3	HYI	Homo sapiens	Q5T013	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	FAM156B	Homo sapiens	Q8NDB6	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	SNX7	Homo sapiens	Q9UNH6	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	SNX7	Homo sapiens	Q9UNH6	Y2H Array	25416956
Intra	TEX11	Q8IYF3	SNX7	Homo sapiens	Q9UNH6	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	25416956
Intra	TEX11	Q8IYF3	GATAD2B	Homo sapiens	Q8WXI9	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	25416956
Intra	TEX11	Q8IYF3	MAPKBP1	Homo sapiens	O60336	Validated Y2H	25416956
Intra	TEX11	Q8IYF3	MAPKBP1	Homo sapiens	O60336	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spermatogenic Failure, X-Linked, 2	SPGFX2 Male Infertility From Defect In Meiosis Spermatogenic Failure, X-Linked 2 X-Linked Spermatogenic Failure 2
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Oligospermia
Spermatogenic Failure, X-Linked, 1	Sertoli Cell-Only Syndrome Germinal Cell Aplasia Del Castillo Syndrome SPGFX1 X-Linked Spermatogenic Failure 1 Congenital Absence Of Germinal Epithelium Of Testes
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Acrodermatitis
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Spermatogenic Failure 10	SPGF10 Spermatogenic Failure With Defective Sperm Annulus
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Oligoasthenoteratozoospermia	Oat Oligoasthenoteratospermia
Spermatogenic Failure 5	Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna SPGF5 Macrocephalic Sperm Head Syndrome Male Infertility Due To Macrozoospermia Infertility Associated With Multitailed Spermatozoa And Excessive Dna Macrozoospermia Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid Large-Headed Multiflagellar Polyploid Spermatozoa Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Epididymo-Orchitis
Orchitis	Inflammation Of Testis Orchititis Mumps Orchitis
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14389	TEX11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TEX11	VGNC	VGNC:78316
Bos taurus	TEX11	VGNC	VGNC:35760
Mus musculus	TEX11	MGD	MGI:1933237
Rattus norvegicus	TEX11	RGD	RGD:1560239
Felis catus	TEX11	VGNC	VGNC:82314
Canis familiaris	TEX11	VGNC	VGNC:47265
Others	TEX11	NCBI