SEPTIN1 - septin 1 Gene

Also Known as LARP; SEP1; DIFF6; SEPT1; PNUTL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1731

About SEPTIN1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,378,135-30,382,815 (from NCBI)

This gene has 11 transcripts (splice variants), 104 orthologues and 12 paralogues. Biased expression in lymph node (RPKM 27.2), spleen (RPKM 18.3) and 9 other tissues.

Summary

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

SEPTIN1 Products (2)

mRNA Protein Name
NM_001365977.2 NP_001352906.1 septin-1
NM_052838.6 NP_443070.6 septin-1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16179162 GOA
Cellular Component GO Annotation Evidence References Source
located in midbody IDA
IDA: Inferred from direct assay
19799413 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEPTIN1 Protein Structure

Septin

Septin: Septin (69 - 345)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

septin-1

  • differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase)

SEPTIN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEPTIN1 Q8WYJ6 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 GPSM1 Homo sapiens Q86YR5-3
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 GPSM1 Homo sapiens Q86YR5-3
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 DNAJB13 Homo sapiens P59910
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 DNAJB13 Homo sapiens P59910
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 AMOT Homo sapiens A2BDD9
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 AMOT Homo sapiens A2BDD9
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN12 Homo sapiens Q8IYM1
Y2H Array
31515488
Intra
SEPTIN1 Q8WYJ6 SEPTIN12 Homo sapiens Q8IYM1
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN12 Homo sapiens Q8IYM1
Y2H Array
25416956
Intra
SEPTIN1 Q8WYJ6 SEPTIN12 Homo sapiens Q8IYM1
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 MRPL12 Homo sapiens P52815
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 MRPL12 Homo sapiens P52815
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Anti Tag CoIP
33961781
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Anti Tag CoIP
28514442
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Y2H Prey Pooling
25416956
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Y2H Array
25416956
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN5 Homo sapiens Q99719
Validated Y2H
25416956
Intra
SEPTIN1 Q8WYJ6 AMOT Homo sapiens Q4VCS5-2
Validated Y2H
25416956
Intra
SEPTIN1 Q8WYJ6 AURKB Homo sapiens Q96GD4
Y2H
21988832
Intra
SEPTIN1 Q8WYJ6 AURKB Homo sapiens Q96GD4
IF
16179162
Intra
SEPTIN1 Q8WYJ6 AURKB Homo sapiens Q96GD4
Protein Kinase Assay
16179162
Intra
SEPTIN1 Q8WYJ6 SEPTIN6 Homo sapiens Q14141
Anti Tag CoIP
33961781
Intra
SEPTIN1 Q8WYJ6 SEPTIN6 Homo sapiens Q14141
Y2H Prey Pooling
25416956
Intra
SEPTIN1 Q8WYJ6 SEPTIN6 Homo sapiens Q14141
Y2H Pooling
16189514
Intra
SEPTIN1 Q8WYJ6 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN3 Homo sapiens Q9UH03
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN3 Homo sapiens Q9UH03
Anti Tag CoIP
33961781
Intra
SEPTIN1 Q8WYJ6 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra
SEPTIN1 Q8WYJ6 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
SEPTIN1 Q8WYJ6 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN11 Homo sapiens Q9NVA2
Validated Y2H
32296183
Intra
SEPTIN1 Q8WYJ6 SEPTIN11 Homo sapiens Q9NVA2
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Neuralgia

  • Neuralgic Amyotrophy

  • Brachial Plexus Neuritis

  • Neuralgic Shoulder Amyotrophy

  • Acute Brachial Plexus Neuritis

  • Immune Brachial Plexus Neuropathy

  • Mononeuritis Multiplex With Brachial Predilection

  • Parsonage-Turner Syndrome
Brachial Plexus Neuropathy

  • Brachial Plexopathy

  • Brachial Plexus Neuropathies

  • Brachial Plexus Disorder

  • Bpn - [Brachial Plexus Neuropathy]

  • Brachial Plexus Disease

  • Neuropathic Plexus Brachialis

  • Brachial Plexus Syndrome

  • Brachial Plexus Irritation

  • Brachial Plexus Lesion

  • Brachial Plexus Pressure

  • Compression Of Brachial Plexus
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12681 SEPTIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SEPTIN1 VGNC VGNC:34449
Macaca mulatta SEPTIN1 VGNC VGNC:77323
Felis catus SEPTIN1 VGNC VGNC:65008
Mus musculus SEPTIN1 MGD MGI:1858916
Rattus norvegicus SEPTIN1 RGD RGD:1307216
Canis familiaris SEPTIN1 VGNC VGNC:46010
Others SEPTIN1 NCBI