DDIT4L - DNA damage inducible transcript 4 like Gene
Also Known as REDD2; Rtp801L
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 115265
About DDIT4L
Cytogenetic location: 4q24
Genomic coordinates (GRCh38): 4:100,185,870-100,190,468 (from NCBI)
This gene has 3 transcripts (splice variants), 184 orthologues and 1 paralogue. Biased expression in prostate (RPKM 12.6), kidney (RPKM 5.8) and 10 other tissues.
Summary
Predicted to be involved in negative regulation of signal transduction. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
DDIT4L Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_145244.4 | NP_660287.1 | DNA damage-inducible transcript 4-like protein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
DDIT4L Protein Structure
RTP801_C
RTP801_C: RTP801 C-terminal region (65 - 183)
- 0
- 100
- 193 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
DNA damage-inducible transcript 4-like protein |
|
DDIT4L Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
DDIT4L | Q96D03 | CATIP | Homo sapiens | Q7Z7H3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TRIM74 | Homo sapiens | Q86UV6-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TRIM74 | Homo sapiens | Q86UV6-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MORF4L1 | Homo sapiens | Q9UBU8-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NUDT22 | Homo sapiens | Q9BRQ3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CABP5 | Homo sapiens | Q9NP86 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NGB | Homo sapiens | Q9NPG2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | ARHGEF3 | Homo sapiens | Q9NR81 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NUDT11 | Homo sapiens | Q96G61 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TARS2 | Homo sapiens | Q9BW92 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CHMP1A | Homo sapiens | Q9HD42 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | SCOC | Homo sapiens | Q9UIL1-3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NXT2 | Homo sapiens | Q9NPJ8-3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MEMO1 | Homo sapiens | Q9Y316 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PUF60 | Homo sapiens | Q9UHX1-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CARD9 | Homo sapiens | Q9H257-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | EMILIN1 | Homo sapiens | Q9Y6C2-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NEK6 | Homo sapiens | Q9HC98-4 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CTNNA3 | Homo sapiens | Q9UI47-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | BANF2 | Homo sapiens | Q9H503-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NDRG4 | Homo sapiens | Q9ULP0-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CPNE7 | Homo sapiens | Q9UBL6-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | XPNPEP1 | Homo sapiens | Q9NQW7-3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PITX2 | Homo sapiens | Q99697-2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TFPT | Homo sapiens | P0C1Z6 | 27107012 | |
|
Intra
|
DDIT4L | Q96D03 | TFPT | Homo sapiens | P0C1Z6 | 27107012 | |
|
Intra
|
DDIT4L | Q96D03 | NHLRC4 | Homo sapiens | P0CG21 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NHLRC4 | Homo sapiens | P0CG21 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | BCL2L14 | Homo sapiens | Q9BZR8 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PLAA | Homo sapiens | Q9Y263 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TCP11L1 | Homo sapiens | Q9NUJ3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PPIL1 | Homo sapiens | Q9Y3C6 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PRPF18 | Homo sapiens | Q99633 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | WHRN | Homo sapiens | Q9P202 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | LSM7 | Homo sapiens | Q9UK45 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | LSM7 | Homo sapiens | Q9UK45 | 25416956 | |
|
Intra
|
DDIT4L | Q96D03 | LSM7 | Homo sapiens | Q9UK45 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | LSM7 | Homo sapiens | Q9UK45 | 31515488 | |
|
Intra
|
DDIT4L | Q96D03 | LSM7 | Homo sapiens | Q9UK45 | 25416956 | |
|
Intra
|
DDIT4L | Q96D03 | LSM7 | Homo sapiens | Q9UK45 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | VBP1 | Homo sapiens | P61758 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | VBP1 | Homo sapiens | P61758 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | EXOSC5 | Homo sapiens | Q9NQT4 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | EXOSC1 | Homo sapiens | Q9Y3B2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | LSM5 | Homo sapiens | Q9Y4Y9 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | SEPTIN5 | Homo sapiens | Q99719 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | ACY3 | Homo sapiens | Q96HD9 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TSSK3 | Homo sapiens | Q96PN8 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TSSK3 | Homo sapiens | Q96PN8 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PARVG | Homo sapiens | Q9HBI0 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MORF4L2 | Homo sapiens | Q15014 | 25416956 | |
|
Intra
|
DDIT4L | Q96D03 | MORF4L2 | Homo sapiens | Q15014 | 25416956 | |
|
Intra
|
DDIT4L | Q96D03 | IL36RN | Homo sapiens | Q9UBH0 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | SH3BGRL3 | Homo sapiens | Q9H299 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PBK | Homo sapiens | Q96KB5 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PSMB9 | Homo sapiens | P28065 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PSMB9 | Homo sapiens | P28065 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MIEN1 | Homo sapiens | Q9BRT3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | SNRPG | Homo sapiens | P62308 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | SNRPG | Homo sapiens | P62308 | 32814053 | |
|
Intra
|
DDIT4L | Q96D03 | SNRPG | Homo sapiens | P62308 | 32814053 | |
|
Intra
|
DDIT4L | Q96D03 | SNRPG | Homo sapiens | P62308 | 32814053 | |
|
Intra
|
DDIT4L | Q96D03 | NIBAN1 | Homo sapiens | Q9BZQ8 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MYLIP | Homo sapiens | Q8WY64 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MYLIP | Homo sapiens | Q8WY64 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MYG1 | Homo sapiens | Q9HB07 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | DCTPP1 | Homo sapiens | Q9H773 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | DUSP23 | Homo sapiens | Q9BVJ7 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | C14orf119 | Homo sapiens | Q9NWQ9 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MAPRE3 | Homo sapiens | Q9UPY8 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | SEPTIN3 | Homo sapiens | Q9UH03 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | HSPB7 | Homo sapiens | Q9UBY9 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CALCOCO2 | Homo sapiens | Q13137 | 25416956 | |
|
Intra
|
DDIT4L | Q96D03 | CALCOCO2 | Homo sapiens | Q13137 | 25416956 | |
|
Intra
|
DDIT4L | Q96D03 | HMG20A | Homo sapiens | Q9NP66 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | C19orf25 | Homo sapiens | Q9UFG5 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TCF19 | Homo sapiens | Q9Y242 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CEP19 | Homo sapiens | Q96LK0 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NME7 | Homo sapiens | Q9Y5B8 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CLK3 | Homo sapiens | P49761 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CLK3 | Homo sapiens | P49761 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | CLK3 | Homo sapiens | P49761 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | STAC3 | Homo sapiens | Q96MF2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TOLLIP | Homo sapiens | Q9H0E2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NAA10 | Homo sapiens | P41227 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | RPRD1B | Homo sapiens | Q9NQG5 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | PLSCR4 | Homo sapiens | Q9NRQ2 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | SEC22A | Homo sapiens | Q96IW7 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TBC1D22B | Homo sapiens | Q9NU19 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | TBC1D22B | Homo sapiens | Q9NU19 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | MLX | Homo sapiens | Q9UH92-3 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | LRATD2 | Homo sapiens | Q96KN1 | 32296183 | |
|
Intra
|
DDIT4L | Q96D03 | NDEL1 | Homo sapiens | Q9GZM8 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Brain Germinoma |
|
|
| Lung Pleomorphic Carcinoma |
|
|
| Zika Fever |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS03616 | DDIT4L Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | DDIT4L | VGNC | VGNC:39838 |
| Felis catus | DDIT4L | VGNC | VGNC:61391 |
| Rattus norvegicus | DDIT4L | RGD | RGD:2322961 |
| Bos taurus | DDIT4L | VGNC | VGNC:27949 |
| Macaca mulatta | DDIT4L | VGNC | VGNC:106566 |
| Mus musculus | DDIT4L | MGD | MGI:1920534 |
| Others | DDIT4L | NCBI |
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