SH3BGRL3 - SH3 domain binding glutamate rich protein like 3 Gene

Also Known as TIP-B1; SH3BP-1; HEL-S-297

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83442

About SH3BGRL3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,280,086-26,281,522 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 3 paralogues. Ubiquitous expression in appendix (RPKM 140.1), colon (RPKM 114.4) and 25 other tissues.

Summary

Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

SH3BGRL3 Products (1)

mRNA Protein Name
NM_031286.4 NP_112576.1 SH3 domain-binding glutamic acid-rich-like protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables glutathione transferase activity IDA
IDA: Inferred from direct assay
11137621 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
34380438 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11137621 GOA
located in ruffle membrane IMP
IMP: Inferred from mutant phenotype
34380438 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3BGRL3 Protein Structure

SH3BGR

SH3BGR: SH3-binding, glutamic acid-rich protein (3 - 93)

  • 0
  • 93 a.a.
Protein Preferred Names Protein Names

SH3 domain-binding glutamic acid-rich-like protein 3

  • SH3 domain binding glutamic acid-rich protein like 3

SH3BGRL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SH3BGRL3 Q9H299 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
SH3BGRL3 Q9H299 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prune Belly Syndrome

  • Eagle-Barrett Syndrome

  • Abdominal Muscle Deficiency Syndrome

  • PBS

  • Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism

  • Egbrs

  • Eagle-Barret Syndrome

  • Urethral Obstruction Sequence

  • Obrinsky Syndrome

  • Triad Syndrome

  • Obrisnksy Syndrome

  • Euos

  • Early Urethral Obstruction Sequence

  • Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction

  • Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism

  • Abdomen Muscle Deficiency Syndrome

  • Abdomen Muscular Deficiency Syndrome

  • Abdominal Muscular Deficiency Syndrome

  • Abdominal Muscle Aplasia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12829 SH3BGRL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SH3BGRL3 RGD RGD:1308118
Mus musculus SH3BGRL3 MGD MGI:1920973
Felis catus SH3BGRL3 VGNC VGNC:65100
Bos taurus SH3BGRL3 VGNC VGNC:106924
Canis familiaris SH3BGRL3 VGNC VGNC:54866
Others SH3BGRL3 NCBI