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TARS2 - threonyl-tRNA synthetase 2, mitochondrial Gene

Also Known as thrRS; TARSL1; COXPD21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80222

About TARS2

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:150,487,419-150,507,602 (from NCBI)

This gene has 13 transcripts (splice variants), 110 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 7.6), heart (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a member of the class-II Aminoacyl-tRNA Synthetase family. The encoded protein is a mitochondrial Aminoacyl-tRNA Synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]

TARS2 Products (3)

mRNA	Protein	Name
NM_001271895.2	NP_001258824.1	threonine--tRNA ligase, mitochondrial isoform b
NM_001271896.2	NP_001258825.1	threonine--tRNA ligase, mitochondrial isoform c
NM_025150.5	NP_079426.2	threonine--tRNA ligase, mitochondrial isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables aminoacyl-tRNA editing activity	IDA IDA: Inferred from direct assay	26811336	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	26811336	GOA
enables threonine-tRNA ligase activity	IDA IDA: Inferred from direct assay	26811336	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TARS2 Protein Structure

TGS

tRNA_SAD

tRNA-synt_2b

HGTP_anticodon

0
200
400
600
718 a.a.

Protein Preferred Names	Protein Names
threonine--tRNA ligase, mitochondrial	threonyl-tRNA synthetase 2, mitochondrial (putative)

TARS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TARS2	Q9BW92	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	TARS2	Q9BW92	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	TARS2	Q9BW92	TARS3	Homo sapiens	A2RTX5	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	TARS3	Homo sapiens	A2RTX5	Y2H Array	32296183
Intra	TARS2	Q9BW92	SYPL1	Homo sapiens	Q16563	Y2H Array	32296183
Intra	TARS2	Q9BW92	SYPL1	Homo sapiens	Q16563	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	SFT2D1	Homo sapiens	Q8WV19	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	SFT2D1	Homo sapiens	Q8WV19	Y2H Array	32296183
Intra	TARS2	Q9BW92	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	TARS2	Q9BW92	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	TARS2	Q9BW92	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	SLC17A9	Homo sapiens	Q9BYT1	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	SLC17A9	Homo sapiens	Q9BYT1	Validated Y2H	32296183
Intra	TARS2	Q9BW92	SLC17A9	Homo sapiens	Q9BYT1	Y2H Array	32296183
Intra	TARS2	Q9BW92	ASB6	Homo sapiens	Q9NWX5	Validated Y2H	32296183
Intra	TARS2	Q9BW92	ASB6	Homo sapiens	Q9NWX5	Y2H Array	32296183
Intra	TARS2	Q9BW92	ASB6	Homo sapiens	Q9NWX5	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	TARS2	Q9BW92	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	PLIN3	Homo sapiens	O60664	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	PLIN3	Homo sapiens	O60664	Y2H Array	32296183
Intra	TARS2	Q9BW92	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	TARS2	Q9BW92	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	TARS2	Q9BW92	MAL2	Homo sapiens	Q969L2	Y2H Array	32296183
Intra	TARS2	Q9BW92	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 21	COXPD21 Combined Oxidative Phosphorylation Defect Type 21 Combined Oxidative Phosphorylation Deficiency, Type 21
Combined Oxidative Phosphorylation Deficiency
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2	MLASA2 Myopathy With Lactic Acidosis And Sideroblastic Anemia 2 Myopathy, Lactic Acidosis, And Sideroblastic Anemia, Type 2
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Combined Oxidative Phosphorylation Deficiency 12	COXPD12 Ltbl Leukoencephalopathy With Thalamus And Brainstem Involvement And High Lactate Leukoencephalopathy-Thalamus And Brainstem Anomalies-High Lactate Syndrome Combined Oxidative Phosphorylation Defect Type 12 Combined Oxidative Phosphorylation Deficiency, Type 12
Perrault Syndrome	Gonadal Dysgenesis, Xx Type, With Deafness Ovarian Dysgenesis With Sensorineural Deafness Gonadal Dysgenesis, Xx Type Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance Xx Gonodal Dysgenesis-Deafness Syndrome Xx Gonodal Dysgenesis-Hearing Loss Syndrome Gonadal Dysgenesis Xx Type Deafness
Mitochondrial Encephalomyopathy	Mitochondrial Encephalomyopathies Encephalomyopathy, Mitochondrial
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Spastic Ataxia	Spax Ataxia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14210	TARS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TARS2	RGD	RGD:1308283
Canis familiaris	TARS2	VGNC	VGNC:49110
Macaca mulatta	TARS2	VGNC	VGNC:78255
Felis catus	TARS2	VGNC	VGNC:65956
Bos taurus	TARS2	VGNC	VGNC:49571
Mus musculus	TARS2	MGD	MGI:1919057
Others	TARS2	NCBI