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TARS3 - threonyl-tRNA synthetase 3 Gene

Also Known as TARSL2; ThrRS-L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 123283

About TARS3

This gene has 7 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues.

Summary

Predicted to enable threonine-tRNA Ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TARS3 Products (1)

mRNA	Protein	Name
NM_152334.3	NP_689547.2	threonine--tRNA ligase 2, cytoplasmic

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24312579	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TARS3 Protein Structure

TGS

tRNA_SAD

tRNA-synt_2b

HGTP_anticodon

0
200
400
600
802 a.a.

Protein Preferred Names	Protein Names
threonine--tRNA ligase 2, cytoplasmic	probable threonine--tRNA ligase 2, cytoplasmic

TARS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TARS3	A2RTX5	b2rdx5_human	Homo sapiens	B2RDX5	Validated Y2H	25416956
Intra	TARS3	A2RTX5	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	32296183
Intra	TARS3	A2RTX5	TARS1	Homo sapiens	P26639	Validated Y2H	25416956
Intra	TARS3	A2RTX5	TARS1	Homo sapiens	P26639	Validated Y2H	32296183
Intra	TARS3	A2RTX5	TARS2	Homo sapiens	Q9BW92	Validated Y2H	32296183
Intra	TARS3	A2RTX5	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	TARS3	A2RTX5	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	TARS3	A2RTX5	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	TARS3	A2RTX5	ARPC3	Homo sapiens	O15145	Validated Y2H	32296183
Intra	TARS3	A2RTX5	ATF4	Homo sapiens	P18848	Y2H Array	32296183
Intra	TARS3	A2RTX5	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
Intra	TARS3	A2RTX5	ATF4	Homo sapiens	P18848	Validated Y2H	32296183
Intra	TARS3	A2RTX5	ECSIT	Homo sapiens	Q9BQ95	Validated Y2H	32296183
Intra	TARS3	A2RTX5	ECSIT	Homo sapiens	Q9BQ95	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Granulomatous Myositis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14211	TARS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TARS3	VGNC	VGNC:35606
Rattus norvegicus	TARS3	RGD	RGD:1311308
Canis familiaris	TARS3	VGNC	VGNC:47111
Mus musculus	TARS3	MGD	MGI:2444486
Macaca mulatta	TARS3	VGNC	VGNC:78205
Felis catus	TARS3	VGNC	VGNC:65957
Others	TARS3	NCBI