ATF4 - activating transcription factor 4 Gene

Also Known as CREB2; TXREB; CREB-2; TAXREB67

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 468

About ATF4

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,520,559-39,522,686 (from NCBI)

This gene has 11 transcripts (splice variants), 269 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 183.9), fat (RPKM 87.6) and 25 other tissues.

Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic Amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

ATF4 Products (2)

mRNA	Protein	Name
NM_001675.4	NP_001666.2	cyclic AMP-dependent transcription factor ATF-4
NM_182810.3	NP_877962.1	cyclic AMP-dependent transcription factor ATF-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15788408	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11960987	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11478948	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11478948	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16343488	GOA
enables leucine zipper domain binding	IDA IDA: Inferred from direct assay	11478948	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	17267404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9488481	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22915762	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	12871976	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21113145	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in HRI-mediated signaling	IDA IDA: Inferred from direct assay	32132706	GOA
involved in L-asparagine metabolic process	IDA IDA: Inferred from direct assay	11960987	GOA
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	22915762	GOA
involved in cellular response to leucine starvation	IDA IDA: Inferred from direct assay	17267404	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	21113145	GOA
involved in integrated stress response signaling	IDA IDA: Inferred from direct assay	32132707	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	23392669	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15775988	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11960987	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16445384	GOA
involved in positive regulation of transcription by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	22915762	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11478948	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15788408	GOA
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	22915762	GOA
involved in regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15109498	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	12871976	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	21113145	GOA
involved in response to nutrient levels	IDA IDA: Inferred from direct assay	11960987	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATF1-ATF4 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	GOA
part of ATF4-CREB1 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	GOA
part of CHOP-ATF4 complex	IDA IDA: Inferred from direct assay	11478948	GOA
part of CHOP-ATF4 complex	IPI IPI: Inferred from physical interaction	18940792	GOA
located in Lewy body core	IDA IDA: Inferred from direct assay	23392669	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23392669	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	23392669	GOA
located in nuclear periphery	IDA IDA: Inferred from direct assay	23392669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11478948	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF4 Protein Structure

bZIP_1

0
100
200
300
351 a.a.

Protein Preferred Names	Protein Names
cyclic AMP-dependent transcription factor ATF-4	DNA-binding protein TAXREB67

ATF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATF4	P18848	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	BFSP2	Homo sapiens	Q13515	Validated Y2H	32296183
Intra	ATF4	P18848	BFSP2	Homo sapiens	Q13515	Y2H Array	25416956
Intra	ATF4	P18848	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	ATF4	P18848	EXOC1	Homo sapiens	Q9NV70	Validated Y2H	32296183
Intra	ATF4	P18848	CEP83	Homo sapiens	Q9Y592-2	Validated Y2H	32296183
Intra	ATF4	P18848	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	ATF4	P18848	CEBPA	Homo sapiens	P49715	Peptide Array	20102225
Intra	ATF4	P18848	TBC1D25	Homo sapiens	Q3MII6	Anti Tag CoIP	33961781
Intra	ATF4	P18848	TBC1D25	Homo sapiens	Q3MII6	Anti Tag CoIP	28514442
Intra	ATF4	P18848	JDP2	Homo sapiens	Q8WYK2	Validated Y2H	32296183
Intra	ATF4	P18848	NFE2L2	Homo sapiens	Q16236	CH-IP	26700459
Intra	ATF4	P18848	NFE2L2	Homo sapiens	Q16236	FRET	23661758
Intra	ATF4	P18848	SAPCD2	Homo sapiens	Q86UD0	Validated Y2H	32296183
Intra	ATF4	P18848	MAF	Homo sapiens	O75444	FRET	23661758
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Validated Y2H	32296183
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Y2H Array	25416956
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	11238952
Intra	ATF4	P18848	POLR2C	Homo sapiens	P19387	Anti Tag CoIP	12860379
Intra	ATF4	P18848	POLR2C	Homo sapiens	P19387	Pull Down	12860379
Intra	ATF4	P18848	HAUS7	Homo sapiens	Q99871	Y2H Pooling	16189514
Intra	ATF4	P18848	HAUS7	Homo sapiens	Q99871	Y2H Pooling	19447967
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Anti Tag CoIP	25416956
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Anti Tag CoIP	12743605
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Y2H Array	25416956
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Y2H Array	20211142
Intra	ATF4	P18848	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Validated Y2H	32296183
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Validated Y2H	25416956
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Y2H Array	25416956
Intra	ATF4	P18848	CREBZF	Homo sapiens	Q9NS37	Pull Down	16343488
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	32296183
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Y2H Array	31515488
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	25416956
Intra	ATF4	P18848	TTR	Homo sapiens	P02766	Y2H Pooling	16189514
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	Anti Bait CoIP	19164757
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	Anti Tag CoIP	19164757
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	EMSA	19164757
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	Peptide Array	20102225
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Y2H Array	25416956
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Y2H Pooling	16189514
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Validated Y2H	25416956
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Validated Y2H	32296183
Intra	ATF4	P18848	NAP1L5	Homo sapiens	Q96NT1	Validated Y2H	32296183
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Array	29892012
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Array	31515488
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Array	25416956
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Y2H Array	20211142
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Validated Y2H	25416956
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Validated Y2H	32296183
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Y2H Array	25416956
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Validated Y2H	25416956
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Array	25416956
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Pooling	16189514
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	ATF4	P18848	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	ATF4	P18848	FOSL1	Homo sapiens	P15407	FRET	23661758
Intra	ATF4	P18848	GCC1	Homo sapiens	Q96CN9	Validated Y2H	25416956
Intra	ATF4	P18848	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	ATF4	P18848	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	JUNB	Homo sapiens	P17275	Y2H	21988832
Intra	ATF4	P18848	JUNB	Homo sapiens	P17275	Confocal	21988832
Intra	ATF4	P18848	BATF	Homo sapiens	Q16520	FRET	23661758
Intra	ATF4	P18848	CEBPD	Homo sapiens	P49716	Peptide Array	20102225
Intra	ATF4	P18848	JUN	Homo sapiens	P05412	FRET	23661758
Intra	ATF4	P18848	FOS	Homo sapiens	P01100	Peptide Array	20102225
Intra	ATF4	P18848	FOS	Homo sapiens	P01100	PLA	25241761
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297-2	Y2H	11238952
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297-2	Confocal	11238952
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297-2	Anti Tag CoIP	11238952
Intra	ATF4	P18848	DAPK2	Homo sapiens	Q9UIK4-2	Anti Tag CoIP	21408167
Intra	ATF4	P18848	CEBPB	Homo sapiens	P17676	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

ATF4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80486	ATF4 Antibody (YA605)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
HY-P80553	ATF4 Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P83667	Phospho-ATF4 (Ser219) Antibody	WB	Human
HY-P84148	ATF4 Antibody (YA3845)	WB, IHC-P, ELISA	Human
HY-P84148A	ATF4 Antibody (YA3845)(PBS only)	WB, IHC-P, ELISA	Human
HY-P86576	ATF4 Antibody (YA6268)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Coffin-Lowry Syndrome	CLS Coffin Syndrome 1 Coffin Syndrome Intellectual Disability With Osteocartilaginous Abnormalities Dwarfism, Lean Spastic Type Lean Spastic Dwarfism Mental Retardation With Osteocartilaginous Abnormalities Coffin Lowry Syndrome
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus	Wolcott-Rallison Syndrome Med-Iddm Syndrome Iddm-Med Syndrome Wolcott Rallison Syndrome WRS Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Leukodystrophy	Leukodystrophies
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukoencephalopathy With Vanishing White Matter	Cree Leukoencephalopathy Vanishing White Matter Disease Ovarioleukodystrophy Vanishing White Matter Leukodystrophy Childhood Ataxia With Central Nervous System Hypomyelinization Cach Cach Syndrome Myelinosis Centralis Diffusa VWM Cle Childhood Ataxia With Central Nervous System Hypomyelination Childhood Ataxia With Diffuse Central Nervous System Hypomyelination Cach/Vwm Cach/Vwm Syndrome Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter Cree Leukoencehalopathy Late Infantile Cach Syndrome Juvenile Or Adult Cach Syndrome Congenital Or Early Infantile Cach Syndrome Leukodystrophy With Vanishing White Matter
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13559	Atiprimod		/	Phase 2
HY-13559A	Atiprimod dimaleate		/	Phase 2
HY-160196	HC-7366	Inhibitor	99.58%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112654	GCN2iB		99.83%	Unkown
HY-100355	C18-Ceramide (d18:1/18:0)		99.95%	Unkown
HY-100548	GSK621		98.03%	Unkown
HY-158201	ATF4-IN-1	Activator	99.29%	Unkown
HY-158202	ATF4-IN-2	Inhibitor	99.24%	Unkown
HY-170872	PT-129		98.66%	Unkown
HY-147831	HR-19011		99.64%	Unkown
HY-153339	E235	Activator	99.86%	Unkown
HY-153340	I-152	Activator	98.78%	Unkown
HY-W020952	Palladium(Ⅱ) acetylacetonate		98.2%	Unkown
HY-112056	DIM-C-pPhCO2Me		99.47%	Unkown
HY-158196	PERK/eIF2α activator 1	Activator	98.88%	Unkown
HY-153074	ISR-IN-1	Inhibitor	98.92%	Unkown
HY-153075	ISR-IN-2		/	Unkown
HY-158203	BMP agonist 2	Agonist	99.26%	Unkown
HY-121337	Flurochloridone		99.61%	Unkown
HY-124646	KIRA-7	Inhibitor	99.09%	Unkown
HY-RS01130	ATF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178154	FB231		99.45%	Unkown
HY-181959	APL-4098	Inhibitor	/	Unkown
HY-149918	Antiproliferative agent-23		/	Unkown
HY-112654A	GCN2iB acetate		/	Unkown
HY-117938	T-3861174	Inhibitor	/	Unkown
HY-121033	BS148		/	Unkown
HY-158195	DPP23	Inducer	99.55%	Unkown
HY-158205	HPO-DAEE		/	Unkown
HY-162886	BSO-07	Activator	/	Unkown
HY-170849	Nur77 modulator 4	Inducer	/	Unkown
HY-171438	ATF4 agonist-1		/	Unkown
HY-172784	Anticancer agent 273		/	Unkown
HY-180490	eIF3e-IN-1	Inhibitor	/	Unkown
HY-182360	Cytisine-platinum(IV) prodrug-1		/	Unkown
HY-182781	Anticancer agent 313	Inhibitor	/	Unkown
HY-182938	Autophagy activator-2	Activator	/	Unkown
HY-183331	YXX0237	Activator	/	Unkown
HY-183332	YXX0248	Activator	/	Unkown
HY-183704	ISR activator-5		/	Unkown
HY-P5762A	Phoenixin-14 TFA		/	Unkown
HY-110102	Atiprimod hydrochloride		/	Unkown
HY-112903A	YW3-56 hydrochloride		/	Unkown
HY-138844	3-AP-Me	Activator	/	Unkown
HY-183004	NCP26		/	Unkown
HY-RS16552	Atf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22985	Atf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ATF4	RGD	RGD:621863
Mus musculus	ATF4	MGD	MGI:88096
Canis familiaris	ATF4	VGNC	VGNC:38210
Bos taurus	ATF4	VGNC	VGNC:26242
Macaca mulatta	ATF4	VGNC	VGNC:107770
Felis catus	ATF4	VGNC	VGNC:68509
Others	ATF4	NCBI